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Cianidanol

Cianidanol Structure
Cianidanol structure
CAS No.
154-23-4
Chemical Name:
Cianidanol
Synonyms
CATECHIN;D-CATECHIN;Cianidano;(2R,3S)-2-(3,4-dihydroxyphenyl)chromane-3,5,7-triol;kb-53;catergen;(2R,3S)-;Catechine;cianidanol;d-catechol
CBNumber:
CB0428149
Molecular Formula:
C15H14O6
Molecular Weight:
290.27
MDL Number:
MFCD00075649
MOL File:
154-23-4.mol
Last updated:2024-04-15 15:30:59
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Cianidanol Properties

Melting point 175-177 °C (anhydrous)(lit.)
Boiling point 352.36°C (rough estimate)
alpha D18 +16 to +18.4°
Density 1.2451 (rough estimate)
refractive index 1.4359 (estimate)
storage temp. 2-8°C
solubility DMSO (Slightly), Methanol (Slightly), Water (Slightly, Sonicated, Heated)
pka 9.54±0.10(Predicted)
color Light Orange to Light Brown
Merck 14,1902
InChIKey PFTAWBLQPZVEMU-DZGCQCFKSA-N
LogP 0.510
CAS DataBase Reference 154-23-4
NCI Dictionary of Cancer Terms catechin
FDA UNII 8R1V1STN48
EPA Substance Registry System 2H-1-Benzopyran-3,5,7-triol, 2-(3,4-dihydroxyphenyl)-3,4-dihydro-, (2R,3S)- (154-23-4)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
RTECS  DJ3450000
F  8-10-23
HS Code  29329990
Toxicity LD50 oral in rat: > 10gm/kg

Cianidanol price More Price(38)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 43412 (+)-Catechin analytical standard 154-23-4 10mg $422 2024-03-01 Buy
Sigma-Aldrich 1096790 (+)-Catechin United States Pharmacopeia (USP) Reference Standard 154-23-4 25mg $420 2024-03-01 Buy
TCI Chemical C0705 (+)-Catechin Hydrate >97.0%(HPLC) 154-23-4 1g $65 2021-12-16 Buy
TCI Chemical C0705 (+)-Catechin Hydrate >97.0%(HPLC) 154-23-4 10g $340 2021-12-16 Buy
Sigma-Aldrich PHR1963 (+)-Catechin Pharmaceutical Secondary Standard; Certified Reference Material 154-23-4 50mg $302 2024-03-01 Buy
Product number Packaging Price Buy
43412 10mg $422 Buy
1096790 25mg $420 Buy
C0705 1g $65 Buy
C0705 10g $340 Buy
PHR1963 50mg $302 Buy

Cianidanol Chemical Properties,Uses,Production

Chemical Properties

Tan Solid

Uses

Labelled (+)-Catechin (C217500). (+)-Catechin is a flavonoid found primarily in higher woody plants as (+)-Catechin along with (-)-Epicatechin (cis form). Antidiarrheal.

Uses

procollagen production inhibitoe, hepatoprotectant

Uses

Cianidanol, also known as (+)-catechin; (+)-3,3′4′,5,7-flavanepentol; 3,3′,4′, 5,7-pentahydroxyflavane, [R,3S]-2-[3,4-dihydroxyphenyl]-3,4-dihydro-1[2H]- benzopyran-3,4,7-triol, or 2-(3,4-dihydroxyphenyl)-3,4-dihydro-(2r-trans)-2h- 1-benzopyran-7-triol, is a flavonoid associated with a variety of blood disorders. An association of cianidanol and immune hemolytic anemia and thrombocytopenia has been suggested in numerous case reports. In several reports, the presence of flavonoid-dependent antibodies against red blood cells is evident with cianidanol combining with erythrocyte membranes and inducing development of autoantibodies and antibodies.Several patients had platelet antibodies with increased serum-bindable IgG values without the presence of cianidanol and several with high platelet-associated IgG levels.Antibodies against cianidanol were not detectable in certain cases.The hemolytic anemia caused acute renal failure in some patients and can be life threatening, leading to fatalities. Upon cessation of treatment with cianidanol, hematology appears to return to normal over time.
These side effects do not appear to be specific to cianidanol as the formation of IgE and IgG antibodies to troxerutin (Venoruton) and silymarin (Kegalon) was also evident with patients presenting with fever, skin eruptions, and intravascular hemolysis often demonstrating high IgG titers.Furthermore, cianidanol-induced hemolysis might also occur after sensitization by other flavonoids including rutin.

Definition

ChEBI: The (+)-enantiomer of catechin and a polyphenolic antioxidant plant metabolite.

brand name

Ausoliver;Cirramina;Transepar.

World Health Organization (WHO)

Cianidanol, which is extracted from the tropical plant Uncaria gambir, was introduced in 1976 as an adjunct in the treatment of liver disorders. Following a cluster of cases of haemolytic anaemia reported in 1985 from Naples, Italy, four of which were fatal, the company suspended sales worldwide. Although subsequently reintroduced in Switzerland and France for the treatment of acute and chronic hepatitis-B, it was later definitively withdrawn in Switzerland on detailed reassessment and the manufacturer has now withdrawn the product worldwide.

General Description

(+)-Catechin is an important beneficial compound, belonging to the flavonoid class, which is present abundantly in red wine.

Cianidanol synthesis

20728-73-8
154-23-4
Synthesis of Cianidanol from (2R-trans)-2-[3,4-bis(phenylmethoxy)phenyl]-3,4-dihydro-5,7-bis(phenylmethoxy)-2H-1-benzopyran-3-ol

Cianidanol Preparation Products And Raw materials

Raw materials

Preparation Products

CACAO PIGMENT Procyanidin B1

Cianidanol Suppliers

Global( 354)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Saisier Technology Co., LTD 		+86-18400010335 +86-13102810335 admin@hbsaisier.cn China 424 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21695 55
Nanjing ChemLin Chemical Industry Co., Ltd. 		025-83697070 product@chemlin.com.cn CHINA 3012 60
Shanghai Zheyan Biotech Co., Ltd. 		18017610038 zheyansh@163.com CHINA 3620 58
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD 		+86 18953170293 sales@sdzschem.com China 2931 58
Chengdu Biopurify Phytochemicals Ltd. 		+8618080483897 sales@biopurify.com China 3424 58
Nanjing Dolon Biotechnology Co.,Ltd. 		18905173768 sales@dolonchem.com CHINA 2972 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28180 58
Xi'an Kono chem co., Ltd., 		029-86107037 13289246953 info@konochemical.com China 2995 58
Supplier Advantage
Hebei Saisier Technology Co., LTD 		58
Henan Tianfu Chemical Co.,Ltd. 		55
Nanjing ChemLin Chemical Industry Co., Ltd. 		60
Shanghai Zheyan Biotech Co., Ltd. 		58
career henan chemical co 		58
SHANDONG ZHI SHANG CHEMICAL CO.LTD 		58
Chengdu Biopurify Phytochemicals Ltd. 		58
Nanjing Dolon Biotechnology Co.,Ltd. 		58
Hubei Jusheng Technology Co.,Ltd. 		58
Xi'an Kono chem co., Ltd., 		58

View Lastest Price from Cianidanol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Cianidanol pictures 2024-04-15 Cianidanol
154-23-4
 US $6.00 / KG 25KG More than 99% 2000KG/MONTH Hebei Saisier Technology Co., LTD
Cianidanol; Green tea extract pictures 2024-04-09 Cianidanol; Green tea extract
154-23-4
 US $0.00 / KG 1KG ≥98% HPLC 1000KG Changsha Staherb Natural Ingredients Co., Ltd.
Cianidanol pictures 2023-12-26 Cianidanol
154-23-4
 US $0.00 / kg 1kg 99% 10000 Hebei Jingbo New Material Technology Co., Ltd
  • Cianidanol pictures
  • Cianidanol
    154-23-4
  • US $6.00 / KG
  • More than 99%
  • Hebei Saisier Technology Co., LTD
  • Cianidanol pictures
  • Cianidanol
    154-23-4
  • US $0.00 / kg
  • 99%
  • Hebei Jingbo New Material Technology Co., Ltd

Cianidanol Spectrum

Cianidanol(154-23-4)MSCianidanol(154-23-4)IR1Cianidanol(154-23-4)IR2

154-23-4(Cianidanol)Related Search:

Tetrahydropyran Triphenylphosphine Procyanidin Tea polyphenol 2-Phenylphenol
Tetrahydro-4H-pyran-4-one Hydroxy silicone oil Catechol L-Epicatechin Dihydromyricetin
Silibinin (+/-)-Catechin hydrate Silicristin (-)-CATECHIN GALLATE (-)-CATECHIN HYDRATE
Procyanidin B1 (-)-Epigallocatechin Phenylacetone

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(+)-CATECHIN CATECHIN, (+)- (+)-3,3'4',5,7-FLAVANEPENTOL 3,3',4',5,7-PENTAHYDROXYFLAVANE [2R,3S]-2-[3,4-DIHYDROXYPHENYL]-3,4-DIHYDRO-1[2H]-BENZOPYRAN-3,4,7-TRIOL 2-(3,4-dihydroxyphenyl)-3,4-dihydro-(2r-trans)-2h-1-benzopyran-7-triol 5,7-triol,2-(3,4-dihydroxyphenyl)-3,4-dihydro-,(2R-trans)-2H-1-Benzopyran-3 catechin(flavan) catechinicacid catechol(flavan) catechuicacid catergen cianidanol d-catechol kb-53 2-(3,4-dihydroxyphenyl)chromane-3,5,7-triol (2R,3S) (2R,3S)-2-(3,4-dihydroxyphenyl)chroman-3,5,7-triol CATECHIN 85% (2R,3S)-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol (+)-CATECHIN WITH HPLC 2H-1-Benzopyran-3,5,7-triol,2-(3,4-dihydroxyphenyl)-3,4-dihydro-, (2R,3S)- Catechin，Cianidanol，Cyanidol (+)-Cyanidan-3-ol 2H-1-Benzopyran-3,5,7-triol, 2-(3,4-dihydroxyphenyl)-3,4-dihydro-, (2R-trans)- Cyanidanol CATECHIN, (+)-(AHP)(CALL) (2R,3S)-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyra3,5,7-triol (+)-Catechin, froM green tea (+)-Catechin (25 mg) Catechin(C) (2R,3S)- (+)-Catechin-d3 Biocatechin Cianidanol, Dexcyanidanol Drenoliver Tanningenic acid Cianidanol,(+)-Catechin hydrate Cianidanol(EGCG) (+)-Cyanidol-3 (2R,3S)-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyra3,5,7-triol (+)-Catechin 154-23-4 (+)-Catechin, 99%, from green tea (+)-Catechin Standard (+)-Catechin Hydrate> Cianidanol Solution, 100μg/mL Cianidanol USP/EP/BP (+)-catechin (+)-Catechin (1096790) CATECHIN D-CATECHIN (2R,3S)-2-(3,4-dihydroxyphenyl)chromane-3,5,7-triol Cianidano Catechine (+)-Catechin C (+)-Catechin (25 mg) 154-23-4 15-23-4 Flavonoids Heterocyclic Building Blocks