Acetazolamide
- CAS No.
- 59-66-5
- Chemical Name:
- Acetazolamide
- Synonyms
- 6063;Diamox;Acetazolamid;Acetazolamide for system suitability CRS;N-(5-SULFAMOYL-1,3,4-THIADIAZOL-2-YL)ACETAMIDE;N-(5-[AMINOSULFONYL]-1,3,4-THIADIAZOL-2-YL)ACETAMIDE;Didoc;Donmox;Edemox;Glupax
- CBNumber:
- CB0430959
- Molecular Formula:
- C4H6N4O3S2
- Molecular Weight:
- 222.25
- MDL Number:
- MFCD00003105
- MOL File:
- 59-66-5.mol
- MSDS File:
- SDS
| Melting point | 258-259 °C |
|---|---|
| Density | 1.610 (estimate) |
| refractive index | 1.6270 (estimate) |
| storage temp. | 2-8°C |
| solubility | Soluble in NH4OH (50 mg/mL), DMSO, Methanol and slightly soluble in Ethanol. |
| pka | 7.2(at 25℃) |
| form | solid |
| color | White to Off-White |
| Water Solubility | <0.1 g/100 mL at 22 ºC |
| λmax | 265nm(H2O)(lit.) |
| Merck | 14,53 |
| BRN | 212994 |
| BCS Class | 4 |
| Stability | Hygroscopic |
| InChIKey | BZKPWHYZMXOIDC-UHFFFAOYSA-N |
| CAS DataBase Reference | 59-66-5(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | O3FX965V0I |
| Proposition 65 List | Acetazolamide |
| NCI Drug Dictionary | Diamox |
| ATC code | S01EC01 |
| NIST Chemistry Reference | 2-Acetylamino-1,3,4-thiadiazole-5-sulfonamide(59-66-5) |
| EPA Substance Registry System | Acetazolamide (59-66-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/38-36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| RIDADR | 2811 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | AC8225000 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29350090 | |||||||||
| Toxicity | LD50 oral in mouse: 4300mg/kg | |||||||||
| NFPA 704 |
|
Acetazolamide price More Price(43)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | BP904 | Acetazolamide British Pharmacopoeia (BP) Reference Standard | 59-66-5 | 600MG | $257 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1005004 | Acetazolamide United States Pharmacopeia (USP) Reference Standard | 59-66-5 | 2g | $436 | 2024-03-01 | Buy |
| Sigma-Aldrich | 97582 | Acetazolamide analytical standard | 59-66-5 | 100mg | $76.5 | 2022-05-15 | Buy |
| Alfa Aesar | L07562 | Acetazolamide, 99% | 59-66-5 | 5g | $35.5 | 2024-03-01 | Buy |
| Alfa Aesar | L07562 | Acetazolamide, 99% | 59-66-5 | 25g | $85.8 | 2024-03-01 | Buy |
Acetazolamide Chemical Properties,Uses,Production
Description
Acetazolamide is a drug used for the treatment of glaucoma,epilepsy,altitude sickness,periodic paralysis, chronic macular edema, idiopathic intracranial hypertension, andheart failure. It can also been used for the treatment of altitude sickness, increased intracranial pressure and neuromuscular disorders. In addition, it also has significant effect of diuretic. It belongs to the carbonic anhydrase inhibitorfamilies of medication. It works by decreasing the amount ofhydrogen ionsandbicarbonatein the body.
References
Forwand, S. A., et al. "Effect of acetazolamide on acute mountain sickness." New England Journal of Medicine279.16(1968):839.
Cox, S. N., E. Hay, and A. C. Bird. "Treatment of chronic macular edema with acetazolamide." Archives of Ophthalmology 106.9(1988):1190.
Supuran, Claudiu T. "Acetazolamide for the treatment of idiopathic intracranial hypertension." Expert Review of Neurotherapeutics15.8(2015):851.
Kassamali, R, and D. A. Sica. "Acetazolamide: a forgotten diuretic agent." Cardiology in Review 19.6(2011):276.
Lucas, M., and M. Brown. "Acetazolamide Reduces Hospital Admissions and Length of Stay in Refractory Heart Failure Patients." Heart Lung & Circulation 20.Suppl 2(2011):S6-S6.
https://www.rxlist.com/acetazolamide-drug.htm
https://en.wikipedia.org/wiki/Acetazolamide
Description
Acetazolamide is a weak diuretic with limited use in edema associated with cardiac insufficiency, glaucoma, minor epileptic attacks, and altitude sickness.
Chemical Properties
White Solid
Originator
Diamox ,Lederle,US ,1953
Uses
Acetazolamide is used for epilepsy in the absence of attacks and also in conjunction with other antiepileptic drugs.
Uses
carbonic anhydrase inhibitor, diuretic, antiglaucoma
Uses
Acetazolamide acts as a carbonic anhydrase inhibitor which increases cerebral blood flow. It inhibits water permeability of membranes by interacting with aquaporins. It is used for the medical treatment of glaucoma, epileptic seizure, idiopathic intracranial hypertension, altitude sickness, cystinuria.
Definition
ChEBI: Acetazolamide is a sulfonamide, a member of thiadiazoles and a monocarboxylic acid amide. It has a role as a diuretic, an anticonvulsant and an EC 4.2.1.1 (carbonic anhydrase) inhibitor. It is a conjugate acid of an acetazolamide(1-). It derives from a hydride of a 1,3,4-thiadiazole.
Manufacturing Process
According to REM, hydrazine hydrate is reacted with 2 mols of ammonium
thiocyanate to produce 1,2-bis(thiocarbamoyl)hydrazine which by loss of
ammonia and rearrangement produces 5-amino-2-mercapto-1,3,4-thiadiazole.
That compound is acetyled with acetic anhydride.
Then, as described in US Patent 2,554,816, the 2-acetylamido-5-mercapto-
1,3,4-thiadiazole is converted to the sulfonyl chloride by passing chlorine gas
into a cooled (5-10°C) solution in 33% acetic acid (66 parts to 4 parts of
mercapto compound) used as a reaction medium. Chlorine treatment is
continued for two hours. The crude product can be dried and purified by
recrystallization from ethylene chloride. The pure compound is a white
crystalline solid, MP 194°C, with decomposition, when heated rapidly. The
crude damp sulfonyl chloride is converted to the sulfonamide by addition to a
large excess of liquid ammonia. The product is purified by recrystallization
from water. The pure compound is a white, crystalline solid, MP 259°C, with
decomposition. The yield of sulfonamide was 85% of theory based on
mercapto compound.
An alternative process is described in US Patent 2,980,679 as follows. 15
grams of finely powdered 2-acetylamino-1,3,4-thiadiazole-5-mercaptain are
suspended in 200 ml of water containing 4 grams of potassium bromide. From
0.5 to 1 gram of ferric chloride are subsequently added. The mass is
energetically stirred and 52 grams of liquid bromide are added by increments
for about 45 minutes, while keeping the reaction temperature below 10°C,
and, preferably, at 4-8°C by employing a cooling bath. Stirring is continued
for a further 10 minutes, then the 2-acetylamino-1,3,4-thiadiazole-5-
sulfobromide is collected on a funnel equipped with a porous diaphragm,
thoroughly washed with cold water and finally subjected to amidation with
liquid ammonia. The reaction mixture is allowed to stand for a certain period,
then the ammonia is evaporated, after which the residue is taken up with
diluted ammonia and, after decolorizing with carbon, the sulfonamide is
precipitated with hydrochloric acid. The yield of crude sulfonamide obtained
with this process, with respect to the starting mercapto compound is abut
84%. If the amidation is carried out with 33% aqueous ammonia, the yield is
slightly lower.
brand name
Diamox (Duramed).
Therapeutic Function
Carbonic anhydrase inhibitor, Diuretic, Antiglaucoma
General Description
White to yellowish-white fine crystalline powder. No odor or taste.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
A weak acid and a diazo derivative. Azo, diazo, azido compounds can detonate. This applies in particular to organic azides that have been sensitized by the addition of metal salts or strong acids. Toxic gases are formed by mixing materials of this class with acids, aldehydes, amides, carbamates, cyanides, inorganic fluorides, halogenated organics, isocyanates, ketones, metals, nitrides, peroxides, phenols, epoxides, acyl halides, and strong oxidizing or reducing agents. Flammable gases are formed by mixing materials in this group with alkali metals. Explosive combination can occur with strong oxidizing agents, metal salts, peroxides, and sulfides.
Fire Hazard
Flash point data for Acetazolamide are not available; however, Acetazolamide is probably combustible.
Biochem/physiol Actions
Inhibits water permeability of membranes by interacting with aquaporins
Mechanism of action
Acetazolamide is an aromatic sulfonamide used as a carbonic anhydrase inhibitor. It facilitates production of alkaline urine with an elevated biocarbonate, sodium, and potassium ion concentrations. By inhibiting carbonic anhydrase, the drug suppresses reabsorption of sodium ions in exchange for hydrogen ions, increases reflux of bicarbonate and sodium ions and reduces reflux of chloride ions. During this process, chloride ions are kept in the kidneys to cover of insufficiency of bicarbonate ions, and for keeping an ion balance. Electrolytic contents of fluid secreted by the kidneys in patients taking carbonic anhydrase inhibitors are characterized by elevated levels of sodium, potassium, and bicarbonate ions and a moderate increase in water level. Urine becomes basic, and the concentration of bicarbonate in the plasma is reduced.
Clinical Use
Acetazolamide was the first of the carbonic anhydrase inhibitors to be introduced as an orally effective diuretic, with a diuretic effect that lasts approximately 8 to 12 hours. As mentioned earlier, its diuretic action is limited because of the systemic acidosis it produces. Acetazolamide reduces the rate of aqueous humor formation and is used primarily for reducing intraocular pressure in the treatment of glaucoma. The dose is 250 mg to 1 g per day.
Safety Profile
Poison by subcutaneous and intravenous routes. Moderately toxic by intraperitoneal route. Human systemic effects by ingestion: dyspnea. An experimental teratogen by many routes. Other experimental reproductive effects. When heated to decomposition it emits very toxic fumes of NOx, and SOx,. A carbonic anhydrase inhibitor and dmretic used to treat glaucoma.
Synthesis
Acetazolamide is 5-acetamido-1,3,4-thiadiazole-2-sulfonamide (9.7.5). The synthesis of acetazolamide is based on the production of 2-amino-5-mercapto-1,3, 4-thiadiazole (9.7.2), which is synthesized by the reaction of ammonium thiocyanate and hydrazine, forming hydrazino-N,N-bis-(thiourea) (9.7.1), which cycles into thiazole (9.7.2) upon reaction with phosgene. Acylation of (9.7.2) with acetic anhydride gives 2-acetylamino-5-mercapto-1,3,4-thiadiazol (9.7.3). The obtained product is chlorinated to give 2-acetylamino-5-mercapto-1,3,4-thiadiazol-5-sulfonylchloride (9.7.4), which is transformed into acetazolamide upon reaction with ammonia (9.7.5) [24,25].
Veterinary Drugs and Treatments
Acetazolamide has been used principally in veterinary medicine
for its effects on aqueous
humor production in the treatment of
glaucoma, metabolic alkalosis, and for its diuretic action. It may
be useful as an adjunctive treatment for syringomyelia in dogs.
Acetazolamide’s use in small animals is complicated by a relatively
high occurrence of adverse effects.
In horses, acetazolamide is used as an adjunctive treatment for
hyperkalemic periodic paralysis (HYPP).
In humans, the drug has been used as adjunctive therapy for epilepsy
and for acute high-altitude sickness.
Drug interactions
Potentially hazardous interactions with other drugs
Analgesics: high dose aspirin reduces excretion (risk
of toxicity).
Anti-arrhythmics: increased toxicity if hypokalaemia
occurs.
Antibacterials: effects of methenamine antagonised.
Antiepileptics: increased risk of osteomalacia
with phenytoin and phenobarbital; concentration
of carbamazepine and possibly fosphenytoin and
phenytoin increased.
Antihypertensives: enhanced hypotensive effect.
Antipsychotics: increased risk of ventricular
arrhythmias due to hypokalaemia.
Atomoxetine: increased risk of ventricular
arrhythmias due to hypokalaemia.
Beta-blockers: increased risk of ventricular
arrhythmias due to hypokalaemia with sotalol.
Cardiac glycosides: increased toxicity if hypokalaemia
occurs.
Ciclosporin: possibly increases ciclosporin
concentration.
Cytotoxics: alkaline urine increases methotrexate
excretion; increased risk of ventricular arrhythmias
due to hypokalaemia with arsenic trioxide; increased
risk of nephrotoxicity and ototoxicity with platinum
compounds.
Lithium: lithium excretion increased.
Metabolism
Acetazolamide is tightly bound to carbonic anhydrase and accumulates in tissues containing this enzyme, particularly red blood cells and the renal cortex. It is also bound to plasma proteins. It is excreted unchanged in the urine, renal clearance being enhanced in alkaline urine.
storage
Store at -20°C
Purification Methods
It is recrystallised from water. [Roblin & Clapp J Am Chem Soc 72 4890 1950, Beilstein 27 III/IV 8219.]
Acetazolamide Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12453 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5993 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Nanjing Gold Pharmaceutical Technology Co. Ltd. | 025-84209270 15906146951 | CHINA | 115 | 55 | |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1807 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9352 | 55 |
| Nanjing Finetech Chemical Co., Ltd. | 025-85710122 17714198479 | sales@fine-chemtech.com | CHINA | 885 | 55 |
| Shanxi Naipu Import and Export Co.,Ltd | +86-13734021967 +8613734021967 | kaia@neputrading.com | China | 1011 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
Related articles
- Toxicity of Acetazolamide
- Acetazolamide is a carbonic anhydrase inhibitor. Under normal physiological conditions, the enzyme carbonic anhydrase is respo....
- Feb 24，2022
- Uses and Side effects of Acetazolamide
- Acetazolamide is used to treat glaucoma, a condition in which increased pressure in the eye can lead to gradual loss of vision....
- Nov 11，2019
View Lastest Price from Acetazolamide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-10-16 | Acetazolamide
59-66-5
|
US $0.00 / kg | 1kg | 0.99 | 20tons | Hebei Yanxi Chemical Co., Ltd. | |
 |
2023-08-29 | Acetazolamide
59-66-5
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | |
 |
2023-02-21 | Acetazolamide
59-66-5
|
US $20.00 / kg | 1kg | 99% | 5000 Ton | Hebei Duling International Trade Co. LTD |
-
- Acetazolamide
59-66-5
- US $0.00 / kg
- 0.99
- Hebei Yanxi Chemical Co., Ltd.
-
- Acetazolamide
59-66-5
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
-
- Acetazolamide
59-66-5
- US $20.00 / kg
- 99%
- Hebei Duling International Trade Co. LTD
59-66-5(Acetazolamide)Related Search:
1of4