Parthenolide
- CAS No.
- 20554-84-1
- Chemical Name:
- Parthenolide
- Synonyms
- PTL;Nsc157035;Aids007764;Parthelide;Aids-007764;Parthenolide;PartheNAlide;Parthenolides;parthenolider;Parthenolide>
- CBNumber:
- CB0446848
- Molecular Formula:
- C15H20O3
- Molecular Weight:
- 248.32
- MDL Number:
- MFCD00134592
- MOL File:
- 20554-84-1.mol
- MSDS File:
- SDS
| Melting point | 115-116 °C (lit.) |
|---|---|
| alpha | D20 -81.4° (c = 1.04 in chloroform); D22 -71.4° (c = 0.220 in CH2Cl2) |
| Boiling point | 394.1±42.0 °C(Predicted) |
| Density | 1.13±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 20 mg/ml) |
| form | White solid |
| color | White |
| Merck | 14,7048 |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| InChI | InChI=1S/C15H20O3/c1-9-5-4-8-15(3)13(18-15)12-11(7-6-9)10(2)14(16)17-12/h5,11-13H,2,4,6-8H2,1,3H3/b9-5+/t11-,12-,13+,15+/m0/s1 |
| InChIKey | KTEXNACQROZXEV-PVLRGYAZSA-N |
| SMILES | O1C(=O)C(=C)[C@]2([H])CCC(C)=CCC[C@@]3(C)O[C@]3([H])[C@@]12[H] |t:10| |
| LogP | 2.424 (est) |
| CAS DataBase Reference | 20554-84-1 |
| FDA UNII | 2RDB26I5ZB |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H317 |
| Precautionary statements | P280-P302+P352 |
| Hazard Codes | Xi,C,F |
| Risk Statements | 11-34 |
| Safety Statements | 22-24/25-45-36/37/39-26-16 |
| WGK Germany | 3 |
| RTECS | LY4220000 |
| HS Code | 29322090 |
Parthenolide price More Price(52)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHL89255 | Parthenolide phyproof? Reference Substance | 20554-84-1 | 20MG | $288 | 2024-03-01 | Buy |
| Sigma-Aldrich | 512732 | Parthenolide | 20554-84-1 | 50mg | $99.4 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1500400 | Parthenolide United States Pharmacopeia (USP) Reference Standard | 20554-84-1 | 25mg | $240 | 2024-03-01 | Buy |
| TCI Chemical | P1982 | Parthenolide >97.0%(HPLC) | 20554-84-1 | 25mg | $87 | 2024-03-01 | Buy |
| TCI Chemical | P1982 | Parthenolide >97.0%(HPLC) | 20554-84-1 | 100mg | $258 | 2024-03-01 | Buy |
Parthenolide Chemical Properties,Uses,Production
Description
Parthenolide is an allergen in feverfew (Tanacetum parthenarium).
Chemical Properties
White solid
Uses
Parthenolide is a sesquiterpene lactone from the plant feverfew (T. parthenium). It inhibits the growth of the promastigote form of L. amazonensis (IC50 = 3.6 μg/ml). Parthenolide also induces apoptosis in cancer cells, at least in part by inhibiting NF-κB- and STAT-mediated anti-apoptotic gene transcription. This compound has also been shown to block inflammation by inhibiting signaling through NF-κB. Inhibition of NF-κB by parthenolide can be achieved by direct binding of the pattern recognition receptor NOD2 by parthenolide.
Uses
Antiinflammatory;MAP kinase inhibitor
Uses
Parthenolide is an anti-inflammatory agent used in the treatment of ischemic injury. Also acts as an anti-tumor and anti0leukemia agent targetting acute myeloid leukemia.
Definition
ChEBI: A sesquiterpene lactone and active principle of Feverfew (Tanacetum parthenium).
General Description
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
Biological Activity
The active principle of feverfew (Chrysanthemum parthenium), widely used as a herbal remedy for arthritis and migraine and as a febrifuge. Parthenolide is antisecretory, anti-inflammatory, spasmolytic and inhibits the release of 5-HT from blood platelets. Also inhibits generation of leukotriene B 4 and thromboxane B 2 .
Contact allergens
Parthenolide is a sesquiterpene lactone found Asteraceae- Compositae such as feverfew (Tanacetum parthenium Schultz-Bip.) or congress grass (Parthenium hysterophorus L.).
Biochem/physiol Actions
Parthenolide is a sesquiterpene lactone present abundantly in the leaves and flowers of Tanacetum parthenium. It exhibits anti-cancer properties for the treatment of invasive cancers. Parthenolide exhibits therapeutic effects against inflammation and migraine. It plays a role in signal transduction and activation of transcription (STAT)-inhibition-mediated transcriptional repression of pro-apoptotic genes.
References
1) Kwok et al. (2001), The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IkappaB kinase; Chem. Biol., 8 759 2) Hwang et al. (1996), Inhibition of the expression of inducible cyclooxygenase and proinflammatory cytokines by sequiterpene lactones in macrophages correlates with the inhibition of MAP kinases; Biochem. Biophys. Res. Commun., 226 810 3) Barsby et al. (1992), Feverfew extracts and parthenolide irreversibly inhibit vascular responses of the rabbit aorta; J. Pharm. Pharmacol., 44 737 4) Sumner et al. (1992), Inhibition of 5-lipoxygenase and cyclo-oxygenase in leukocytes by feverfew. Involvement of sesquiterpene lactones and other components; Biochem. Pharmacol., 43 2313 5) Groenewegen et al. (1990), A comparison of the effects of an extract of feverfew and parthenolide, a component of feverfew, on human platelet activity in-vitro; J. Pharm. Pharmacol., 42 553
Parthenolide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
| Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | qinhe02@xaltbio.com | China | 1000 | 58 |
| Chongqing Zhihe Biopharmaceutical Co., Ltd. | +86-18580541567 +86-17782035140 | sales@zhswyy.com | China | 338 | 58 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9348 | 55 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3424 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | sales@dolonchem.com | CHINA | 2972 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
View Lastest Price from Parthenolide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-24 | Parthenolide
20554-84-1
|
US $0.00-0.00 / kg | 0.10000000149011612kg | ≥98% | 20tons | Chongqing Zhihe Biopharmaceutical Co., Ltd. | |
 |
2024-04-23 | Parthenolide; Tanacetum parthenium
20554-84-1
|
US $0.00 / KG | 1KG | 1%-98% HPLC | 1000KG | Changsha Staherb Natural Ingredients Co., Ltd. | |
 |
2024-04-22 | parthenolider
20554-84-1
|
US $50.00 / g | 2g | 99 | 10000 kilograms/month | Hebei Yime New Material Technology Co., Ltd. |
-
- Parthenolide
20554-84-1
- US $0.00-0.00 / kg
- ≥98%
- Chongqing Zhihe Biopharmaceutical Co., Ltd.
-
- Parthenolide; Tanacetum parthenium
20554-84-1
- US $0.00 / KG
- 1%-98% HPLC
- Changsha Staherb Natural Ingredients Co., Ltd.
-
- parthenolider
20554-84-1
- US $50.00 / g
- 99
- Hebei Yime New Material Technology Co., Ltd.