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ChemicalBook >> CAS DataBase List >>(3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one

(3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one

(3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one Structure
(3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one structure
CAS No.
76855-69-1
Chemical Name:
(3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one
Synonyms
4-AA;4-ACETOXYAZETIDIN-2-ONE;(3R,4R)-4-ACETOXY-3-[(R)-(T-BUTYLDIMETHYLSILYLOXY)ETHYL]-2-AZETIDINONE;(3R,4R)-4-ACETOXY-3-[(R)-1-(TERT-BUTYLDIMETHYLSILYLOXY)ETHYL]AZETIDIN-2-ONE;4-AOSA;Azetidon;4AA(AOSA);AOSA (4-AA);4-AA or 4-AOSA;2-Azacyclobutone
CBNumber:
CB0458274
Molecular Formula:
C13H25NO4Si
Molecular Weight:
287.43
MDL Number:
MFCD00077636
MOL File:
76855-69-1.mol
MSDS File:
SDS
Last updated:2023-04-23 13:52:06
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(3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one Properties

Melting point 107-109 °C(lit.)
alpha 51 º (c=1, chloroform)
Boiling point 358.3±27.0 °C(Predicted)
Density 1.03±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility almost transparency in Methanol
form powder to crystal
pka 12.86±0.60(Predicted)
color White to Almost white
optical activity [α]20/D +51°, c = 1 in chloroform
InChIKey GWHDKFODLYVMQG-UBHAPETDSA-N
CAS DataBase Reference 76855-69-1(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 75874VBV1X

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS09
Signal word  Warning
Hazard statements  H317-H319-H411
Precautionary statements  P273-P280-P302+P352-P305+P351+P338
Hazard Codes  Xi,N
Risk Statements  36-43-51/53
Safety Statements  24-26-37-61
RIDADR  UN 3077 9/PG 3
WGK Germany  2
HazardClass  9
PackingGroup  III
HS Code  29337900
NFPA 704
1
2 0

(3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one price More Price(27)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 375845 [3R(1′R,4R)]-(+)-4-Acetoxy-3-[1-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone 98% 76855-69-1 1g $62.4 2024-03-01 Buy
TCI Chemical A1124 (3R,4R)-4-Acetoxy-3-[(R)-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone >98.0%(N) 76855-69-1 5g $258 2024-03-01 Buy
TCI Chemical A1124 (3R,4R)-4-Acetoxy-3-[(R)-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone >98.0%(N) 76855-69-1 25g $931 2024-03-01 Buy
TRC A164500 (3R,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone 76855-69-1 1g $65 2021-12-16 Buy
Biosynth Carbosynth FA16979 (3R,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone 76855-69-1 10g $92.5 2021-12-16 Buy
Product number Packaging Price Buy
375845 1g $62.4 Buy
A1124 5g $258 Buy
A1124 25g $931 Buy
A164500 1g $65 Buy
FA16979 10g $92.5 Buy

(3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one Chemical Properties,Uses,Production

Chemical Properties

white to light yellow crystal powde

Uses

(3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one is an acetoxyazetidinone derivative used as an intermediate in the preparation of carbapenem antibiotics.

Purification Methods

Purify it by chromatography on silica gel (3 x 14cm) for 50g of ester using 20% EtOAc in n-hexane. The eluate is evaporated, and the residue is recrystallised from hexane (white fluffy crystals). [Leanza et al. Tetrahedron 39 2505 1983.]

(3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one Preparation Products And Raw materials

Raw materials

Ethyl acetoacetate Sodium hypochlorite Acetonitrile (R)-(+)-2,2'-Bis(diphenylphosphino)-1,1'-binaphthyl Ethanol
Acetic anhydride Potassium hydroxide (R)-(+)-1,1'-Bi-2-naphthol tert-Butyldimethylsilyl chloride Triethyl orthoformate
2-Mercaptothiazoline Ruthenium(III) chloride Oxygen Triethylamine Palladium
(FORMYLMETHYLENE)TRIPHENYLPHOSPHORANE Benzamide Hydrochloric acid Hydrogen Dichloromethane
1,5-Cyclooctadiene Methanol tert-Butylamine

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Preparation Products

(3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one Suppliers

Global( 378)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 15371 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21695 55
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Accela ChemBio Inc. 		(+1)-858-699-3322 info@accelachem.com United States 19965 58
Xiamen AmoyChem Co., Ltd 		+86-592-6051114 +8618959220845 sales@amoychem.com China 6387 58
Hubei xin bonus chemical co. LTD 		86-13657291602 linda@hubeijusheng.com CHINA 22968 58
Chongqing Chemdad Co., Ltd 		+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 47465 58
Antai Fine Chemical Technology Co.,Limited 		18503026267 info@antaichem.com CHINA 9641 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
career henan chemical co 		58
Accela ChemBio Inc. 		58
Xiamen AmoyChem Co., Ltd 		58
Hubei xin bonus chemical co. LTD 		58
Chongqing Chemdad Co., Ltd 		58
CONIER CHEM AND PHARMA LIMITED 		58
Antai Fine Chemical Technology Co.,Limited 		58

View Lastest Price from (3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one pictures 2023-03-14 (3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one
76855-69-1
 US $34.00 / KG 1KG 99% 5000 tons Hebei Duling International Trade Co. LTD
(3S,4R) -4-acetoxy-3 -[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one pictures 2022-10-09 (3S,4R) -4-acetoxy-3 -[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one
76855-69-1
 US $30.00-28.00 / Kg 1Kg 99.0% up 50 tons per month Xinxiang Hongqi District Houyuan Trading Co.,Ltd
(3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one pictures 2022-09-22 (3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one
US $30.00-28.00 / Kg 1Kg 99.0% up 50 tons per month Xinxiang Hongqi District Houyuan Trading Co.,Ltd

(3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one Spectrum

(3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one(76855-69-1)MS(3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one(76855-69-1)1HNMR(3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one(76855-69-1)IR1(3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one(76855-69-1)IR2(3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one(76855-69-1)Raman

76855-69-1((3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one)Related Search:

Benzyloxyacetyl chloride N-Methyl-2-pyrrolidone Ethyl formate Ethyl propionate Ethyl acrylate
Ethylparaben 2-Butanone oxime Sodium triacetoxyborohydride Dimethyldimethoxysilane Ethylbenzene
Laurocapram 2-Azetidinone Diltiazem hydrochloride 4-Acetoxystyrene Ethyl acetate
Diethoxydimethylsilane Ethanol T-BUTYLDIMETHYLSILANE

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(3s,4r)-4-acetoxy-3-[(r)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one (3R,4R)-(+)-4-ACETOXY-3-[(R)-(T-BUTYLDIMETHYLSILYLOXY)ETHYL]-2-AZETIDINONE (3R,4R)-4-ACETOXY-3-[(R)-(TERT-BUTYLDIMETHYLSILYLOXY)ETHYL]-2-AZETIDINONE (3R,4R)-4-(ACETYLOXY)-3-[(1R)-1-[[(1,1-DIMETHYLETHYL)DIMETHYLSILYL]OXY]ETHYL]-2-AZETIDINONE [3R(1'R,4R)]-(+)-4-ACETOXY-3-[1-(TERT-BUTYLDIMETHYLSILYLOXY)ETHYL]-2-AZETIDINONE (2R,3R)-3-[(R)-1-(TERT-BUTYLDIMETHYLSILYLOXY)ETHYL]-4-OXOAZETIDIN-2-YLACETATE 4-AOSA (3R,4R)-4-acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone 2-Azetidinone, 4-(acetyloxy)-3-[(1R)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-, (3R,4R)- acetoxyazetidinone (3S,4R)-4-acetoxy-3-[-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one (R R(R))-4-ACETOXY-3-(1-TBDMS-OXY)- (3R(1'R,4R))-(+)-4-ACETOXY-3-(1-(T-BUTYL DI -METHYLSILYLOXY)ETH)-2-AZETIDINONE,98 [3R(1′R,4R)]-(+)-4-Acetoxy-3-[1-(tert-butyldimeth (3R,4R)-4-ACETOXY-3-[(3R)-TERT-BUTYLDIMETHYLSILYLOXY)ETHYL]-2-AZETIDINONE 4-ACETOXYAZETIDINE-2-ONE( 4-AA, ABA, AOSA) (3S)-4-(4'-Fluorophenyl)-3-eth （3S,4R）-4-Acetoxy-3-[(R)-1-(tert-butyl 4-AA (INTERMEDIATE OF CARTAPENEM) 4-ACETOXYAZETIDIN-2-ONE (4-AA , 4-ABA OR 4-AOSA) 4-ACETOXYAZETIDIN-2-ONE 4-AA(AOSA)(PENEM INTERMEDIATE ) 4-acetoxyazetidin-2-one(4AA) ACETOXYSILYLOXYAZETIDINONE 4-Acetoxysilyloxyazetidinone [3R(1''R)4R]-4-Acetoxy-3-[1-(tert-butyldimethylsilyloxy)-ethyl]-2-azetidinon 4AA(AOSA) (2R,3R)-3-(2-(tert-butyldimethylsilyloxy)ethyl)-4-oxoazetidin-2-yl acetate (2R,3R)-3-((R)-1-(tert-butyldimethylsiloxy)ethyl)-4-oxoazetidin-2-yl acetate 4-AA or 4-AOSA 4-acetoxy-3-[1-(butyldimethylsilyloxy)ethyl]-2-azetidinone [3R(1R),4R]-4-Acetoxy-3-[1-(tert-butyldimethylsiloxy)ethyl]-2-azetidinone Carbapenem intermediate: Acetoxyazetidinone (3R,4R)-4-Acetoxy-3-[(R)-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone ACETOXYSILYLOXYAZETIDINONE(AOSA) 3R, 4R)-4-acetoxy-3-[(1R)-1-t-butyldimethylsilyloxyethyl]azetidin-2-one intermediates of Meropenem (3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidinone AOSA (4-AA) (3R,4R)-4-Acetoxy-3-[(R)-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone ,98% (3S,4R)-4-Acetoxy-3- (3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone 3R,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldiMethylsilyloxy)ethyl]-2-a 3-(1-(ButyldiMethylsilyloxy)ethyl)-4-oxoazetidin-2-yl acetate (3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldiMethylsilyoxy)ethyl]azetidin-2-one (1'R,3R,4R)-4-Acetoxy-3-(1'-tert-butyldiMethylsilyloxyethyl)-2-azetidinone (3R,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldiMethylsiloxy)ethyl]azetidin-2-one (3R,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldiMethylsilyloxy)ethyl]azetidinone [3R-[3α(R*),4β]]-4-(Acetyloxy)-3-[1-[[(1,1-diMethylethyl)diMethylsilyl]oxy]ethyl]-2-azetidinone (3R,4R)-(+)-4-Acetoxy-3-[1-(R)-(tert-butyldiMethylsilyloxy)ethyl]-2-azetidinone, 98% (2R,3S)-3-[(1R)-1-[(tert-butyldiMethylsilyl)oxy]ethyl]-4-oxoazetidin-2-yl acetate 4-AA ((2R,3R)-3-((R)-1-(tert-Butyldimethylsilyloxy)ethyl)-4-oxoazetidin-2-yl acetate) 4- acetoxy azetidone (3R,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one AOSA (4-AA) (3S 4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethy (1'R,3R,4R)-4-Acetoxy-3-(1'-tert-butyidimethylsilyloxyethyl)-2-azetidinone 4-AA ((2R,3R)-3-((R)-1 2-Azacyclobutone 2-[3-[1-[tert-butyl(dimethyl)silyl]oxyethyl]-4-oxo-2-azetidinyl]acetate