XESTOSPONGIN C
- CAS No.
- 88903-69-9
- Chemical Name:
- XESTOSPONGIN C
- Synonyms
- XEC;XESTOSPONGIN;ARGUSPONGINE E;XESTOSPONGIN C;(-)-Xestospongin C;PQYOPBRFUUEHRC-HCKQMYSWSA-N;Xestospongin C 4-((1H-Indol-7-yl)carbamoyl)phenyl diethylcarbamate;(1R,4aR,11R,12aS,13S,16aS,23R,24aS)-Eicosahydro-5H,17H-1,23:11,13-diethano-2H,14H-[1,11]dioxacycloeicosino[2,3-b:12,13-b']dipyridine;5H,17H-1,23:11,13-Diethano-2H,14H-[1,11]dioxacycloeicosino[2,3-b:12,13-b']dipyridine, eicosahydro-, (1R,4aR,11R,12aS,13S,16aS,23R,24aS)-;[1R-(1R*,4AR*,11R*,12AS*,13S*,16AS*,23R*,24AS*)]-EICOSAHYDRO-5H,17H-1,23:11,13-DIETHANO-2H,14H-[1,11]DIOXACYCLOEICOSINO[2,3-B:12,13-B']DIPYRIDINE
- CBNumber:
- CB0479020
- Molecular Formula:
- C28H50N2O2
- Molecular Weight:
- 446.71
- MDL Number:
- MFCD01862629
- MOL File:
- 88903-69-9.mol
| Melting point | 146-147 °C(Solv: acetone (67-64-1)) |
|---|---|
| Boiling point | 564.7±35.0 °C(Predicted) |
| Density | 1.05±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO: soluble |
| form | film |
| pka | 7.73±0.20(Predicted) |
| color | off-white |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
XESTOSPONGIN C price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | X2628 | Xestospongin C film | 88903-69-9 | 10μg | $463 | 2024-03-01 | Buy |
| Sigma-Aldrich | X2628 | Xestospongin C film | 88903-69-9 | 50μg | $1670 | 2024-03-01 | Buy |
| Cayman Chemical | 64950 | Xestospongin C ≥90% | 88903-69-9 | 10μg | $86 | 2024-03-01 | Buy |
| Cayman Chemical | 64950 | Xestospongin C ≥90% | 88903-69-9 | 50μg | $353 | 2024-03-01 | Buy |
| Cayman Chemical | 64950 | Xestospongin C ≥90% | 88903-69-9 | 100μg | $629 | 2024-03-01 | Buy |
XESTOSPONGIN C Chemical Properties,Uses,Production
Description
Xestospongin C (88903-69-9) is a potent and reversible inhibitor of IP3-mediated Ca2+?release, IC50?= 358 nM.1?Experiments with guinea-pig ileum permeabilized with alpha toxin revealed that Xestospongin C inhibits the IP3 receptor but not the ryanodine receptor in SR membranes. In intact smooth muscle cells it inhibits voltage-dependent Ca2+?and K+?currents at a concentration range similar to that at which it inhibits the IP3 receptor. Xestospongin C is a useful tool for probing the involvement of IP3 receptors in cellular signaling.3?Cell permeable.
Uses
Xestospongin C is a potent, membrane-permeable IP3 receptor blocker.
Uses
Xestospongin C is a marine natural product which was first isolated from Pacific basin sponges, and noted to have vasodilatory properties. Xestospongin C antagonizes the calcium-releasing action of inositol-1,4,5-trisphosphate (IP3) at the receptor level. Inositol phosphates are important signal transduction messengers acting via IP3 receptors to promote the mobilization of Ca2+ from intracellular stores. Xestospongin C blocks the increase in intracellular calcium in vascular smooth muscle cells completely at a concentration of 25 μM. Xestospongin C also inhibits the sarcoplasmic reticulum Ca2+ ATPase pump at concentrations of 700 nM.
Definition
ChEBI: An organic heteropentacyclic compound that is isolated from the marine sponge Xestospongia exigua.
General Description
Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge.
Biochem/physiol Actions
Xestospongin C is a selective, reversible and membrane-permeable inhibitor of IP3 receptor. Reversibly blocks bradykinin- and carbamylcholine- Ca2+ efflux from the endoplasmic reticulum stores.
storage
Store at -20°C
References
1) Wilcox?et al. (1998),?New developments in the molecular pharmacology of the myo-inositol 1,4,5-trisphosphate receptor;? Trends Pharmacol. Sci.,?19?467 2) Ozaki?et al. (2002),?Inhibitory mechanism of xestospongin-C on contraction and ion channels in the intestinal smooth muscle;? Br. J. Pharmacol.,?137?1207 3) Kandasamy?et al. (2013),?Lipopolysaccharide induces endoplasmic store Ca2+-dependent inflammatory responses in lung microvessels;? PLoS One,?8?e63465
XESTOSPONGIN C Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Jinan Yaoyan Pharmaceutical Co., Ltd. | jnyaoyan@163.com | China | 3069 | 58 | |
| Nanjing Meihao Pharmaceutical Technology Co., Ltd. | meitaochem@126.com | meitaochem@126.com | China | 19105 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |