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N-Acetyl-L-proline

CAS No.
68-95-1
Chemical Name:
N-Acetyl-L-proline
Synonyms
AC-PRO-OH;AC-PROLINE;NSC 280718;N-AC-L-PRO;N-Ac-Pro-OH;Ac-L-Pro-Oh;N-Acetyl-Pro;AC-PYRD(2)-OH;Acetylproline;N-ACETYL-L-PRO
CBNumber:
CB0481658
Molecular Formula:
C7H11NO3
Molecular Weight:
157.17
MDL Number:
MFCD00020837
MOL File:
68-95-1.mol
MSDS File:
SDS
Last updated:2024-02-20 10:28:42

N-Acetyl-L-proline Properties

Melting point 115-117 °C
alpha -86 º (c=1 EtOH)
Boiling point 366.2±35.0 °C(Predicted)
Density 1.274±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility Chloroform (Slightly), Methanol (Slightly), Water (Slightly)
form Powder
pka 3.69±0.20(Predicted)
color White to off-white
BRN 83200
InChI InChI=1S/C7H11NO3/c1-5(9)8-4-2-3-6(8)7(10)11/h6H,2-4H2,1H3,(H,10,11)/t6-/m0/s1
InChIKey GNMSLDIYJOSUSW-LURJTMIESA-N
SMILES C(O)(=O)[C@@H]1CCCN1C(C)=O
CAS DataBase Reference 68-95-1(CAS DataBase Reference)
FDA UNII CC8XZ138VZ
NIST Chemistry Reference L-proline, 1-acetyl-(68-95-1)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338
Hazard Codes  Xi
Safety Statements  24/25
WGK Germany  3
HazardClass  IRRITANT
HS Code  29339900
NFPA 704
1
0 0

N-Acetyl-L-proline price More Price(31)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich A0783 N-Acetyl-L-proline 68-95-1 1g $64.4 2024-03-01 Buy
Sigma-Aldrich A0783 N-Acetyl-L-proline 68-95-1 5g $140 2023-06-20 Buy
Alfa Aesar L14300 N-Acetyl-L-proline, 99% 68-95-1 1g $36.3 2023-06-20 Buy
Alfa Aesar L14300 N-Acetyl-L-proline, 99% 68-95-1 5g $106 2023-06-20 Buy
Usbiological 235177 Acetyl-L-proline 99+% 68-95-1 5g $200 2021-12-16 Buy
Product number Packaging Price Buy
A0783 1g $64.4 Buy
A0783 5g $140 Buy
L14300 1g $36.3 Buy
L14300 5g $106 Buy
235177 5g $200 Buy

N-Acetyl-L-proline Chemical Properties,Uses,Production

Chemical Properties

white to off-white powder

Uses

N-Acetyl-L-proline is an aminoacid used in the synthesis of pharmaceutical compounds useful in preventing and treating disorders and syndromes associated with the nervous, vascular, musculoskeletal, o r cutaneous systems.

Definition

ChEBI: N-acetyl-L-proline is a N-acetyl-L-amino acid, a N-acylpyrrolidine, a pyrrolidinemonocarboxylic acid and a L-proline derivative.

Biochem/physiol Actions

N-acetyl-L-proline is an analog of the COOH-terminal dipeptide portion of preferred substrates of angiotensin-converting enzyme (ACE). It may be used in studies of the binding of substrates and inhibitors by ACE and to differentiate the specificities of various aminoacylases.

References

[1] Jingxuan Qiu. “Solubility Behavior and Polymorphism of N-Acetyl-l-proline in 16 Individual Solvents from 283.15 to 323.15 K.” Journal of Chemical & Engineering Data 66 3 (2021): 1533–1542.

Description

N-Acetyl-L-proline (NALP) is an N-acetyl derivative of L-proline, which has wide application in medicine and is commonly utilized as a biologically active supplement. It can also act as an intermediate for synthesizing pharmaceuticals for preventing and treating some disorders and syndromes associated with the nervous, vascular, musculoskeletal, or cutaneous systems. In laboratories, it could play the role of a simple model for the secondary structure of proline-containing peptides. NALP can be acetylated from L-proline via a standard method, in the environment of acetic acid, or by the action of acetic anhydride on aqueous solutions of the products of the alkaline hydrolysis of gelatin followed by extraction. However,  these methods may result in the production of many byproducts[1]. 

N-Acetyl-L-proline Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 340)Suppliers
Supplier Tel Email Country ProdList Advantage
DONBOO AMINO ACID COMPANY
+8613063595538 donboo@donboo.com China 9365 58
Henan Fengda Chemical Co., Ltd
+8613613820652 info@fdachem.com China 5085 58
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Shanghai Daken Advanced Materials Co.,Ltd
+86-371-66670886 info@dakenam.com China 14764 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21700 55
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32480 60
Anqing Chico Pharmaceutical Co., Ltd.
15380796838 chloewu@chicopharm.cn CHINA 341 58
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29914 58
Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28180 58
Accela ChemBio Inc.
(+1)-858-699-3322 info@accelachem.com United States 19965 58

View Lastest Price from N-Acetyl-L-proline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
N-acetyl-L-proline pictures 2024-01-02 N-acetyl-L-proline
68-95-1
US $200.00-1.00 / KG 1KG 99%, 99.5% Sublimated g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd
N-Acetyl-L-proline pictures 2023-08-08 N-Acetyl-L-proline
68-95-1
US $0.00-0.00 / kg 1kg 0.99 50000kg Hebei Yibangte Import and Export Co. , Ltd.
N-Acetyl-L-proline pictures 2023-03-25 N-Acetyl-L-proline
68-95-1
US $56.00 / kg 1kg 99% 5000 tons Hebei Duling International Trade Co. LTD
  • N-acetyl-L-proline pictures
  • N-acetyl-L-proline
    68-95-1
  • US $200.00-1.00 / KG
  • 99%, 99.5% Sublimated
  • Henan Fengda Chemical Co., Ltd
  • N-Acetyl-L-proline pictures
  • N-Acetyl-L-proline
    68-95-1
  • US $0.00-0.00 / kg
  • 0.99
  • Hebei Yibangte Import and Export Co. , Ltd.
(S)-N-Acetylproline L-N-Acetylproline NSC 280718 N-Ac-Pro-OH ASINEX-REAG BAS 16579166 ACETYL-L-PROLINE AC-PYRD(2)-OH AC-PROLINE AC-PRO-OH N-ALPHA-ACETYL-L-PROLINE N-ALPHA-ACETYL-L-PYRROLIDINE-2-CARBOXYLIC ACID N-ACETYL-L-PRO N-ACETYL-L-PROLINE N-AC-L-PRO (S)-1-ACETYL-PYRROLIDINE-2-CARBOXYLIC ACID 1-Acetylproline Acetylproline L-Proline, 1-acetyl- Proline, 1-acetyl-, L- 1-acetyl-L-proline Ac-L-Pro-Oh L-Proline, 1-acetyl- (9CI) (S)-Acetyl-pyrrolidine-2-carboxylic acid Acetyl-L-proline99% N-ACETYL-L-PROLINE (N-AC-L-PRO) N-alpha-Actetyl-L-proline N-Acethyl-L-proline (+/-)-(3-Methoxy-4-hydroxyphenyl)-2-isopropylaminoethanol hydrochloride Benzenemethanol, 4-hydroxy-3-methoxy-a-[[(1-methylethyl)amino]methyl]-, hydrochloride Vanillyl alcohol, a-[(isopropylamino)methyl]-, hydrochloride (2S)-1-Acetylpyrrolidine-2α-carboxylic acid N-Acetyl-L-proline,99% N-ACETYL-L-PROLINE (USP) Ac-Pro-OH ,≥99% (S)-(-)-N-Acetylproline N-Acetyl-L-proline, 99% 1GR N-AN-Acetyl-L-prolineN-Acetyl-L-prolinecetyl-L-proline (2S)-1-acetyl-2-pyrrolidinecarboxylate l-proline n-acetyl N-Acetyl-L-proline USP/EP/BP N-Acetyl-L-Proline extrapure, 98% N-Acetyl-Pro 68-95-1 C7H10NO3 CARBOXYLIC ACID Modified Amino Acids Biochemicals and Reagents BioChemical A - H Amino Acids and Peptides A - H Amino Acids Modified Amino Acids Amino Acid Derivatives Amino Acids chiral N-Acetyl-Amino acid series amino