ChemicalBook >> CAS DataBase List >>MC180295
MC180295
- CAS No.
- 2237942-08-2
- Chemical Name:
- MC180295
- Synonyms
- MC180295;(rel)-MC180295;MC-180295;MC 180295;MC180295 ((REL)-MC180295);MC180295,MC 180295,Cyclin dependent kinase,MC-180295,CDK,inhibit,Inhibitor;Methanone, [4-amino-2-[(1R,2R,4S)-bicyclo[2.2.1]hept-2-ylamino]-5-thiazolyl](2-nitrophenyl)-, rel-
- CBNumber:
- CB04923806
- Molecular Formula:
- C17H18N4O3S
- Molecular Weight:
- 358.41
- MDL Number:
- MFCD31924820
- MOL File:
- 2237942-08-2.mol
Last updated:2023-05-21 10:59:17
MC180295 price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
ChemScene | CS-0081067 | MC180295 98.47% | 2237942-08-2 | 5mg | $650 | 2021-12-16 | Buy |
ChemScene | CS-0081067 | MC180295 98.47% | 2237942-08-2 | 10mg | $950 | 2021-12-16 | Buy |
Biorbyt Ltd | orb573229 | MC180295 >98% | 2237942-08-2 | 100mg | $1802 | 2021-12-16 | Buy |
ChemScene | CS-0081067 | MC180295 98.47% | 2237942-08-2 | 50mg | $2850 | 2021-12-16 | Buy |
Biorbyt Ltd | orb573229 | MC180295 >98% | 2237942-08-2 | 250mg | $3136.5 | 2021-12-16 | Buy |
MC180295 Chemical Properties,Uses,Production
Uses
MC180295 can be useful in combination therapy of BET proteolysis targeting chimeric mol. with CDK9 inhibitor against human multiple myeloma cells.
Biological Activity
MC180295 ((rel)-MC180295) is a novel potent and selective CDK9 inhibitor with IC50 of 5 nM, at least 22-fold selective for CDK9 over other CDKs.
in vivo
MC180295 has antitumor and immunoallergic activity.
target
Target | Value |
CDK9-Cyclin T1 (Cell-free assay) | 5 nM |
CDK4-Cyclin D (Cell-free assay) | 112 nM | tr>
CDK1-Cyclin B (Cell-free assay) | 138 nM |
CDK5-P35 < br/> (Cell-free assay) | 159 nM |
CDK5-P25 (Cell-free assay) | 186 nM |
MC180295 Preparation Products And Raw materials
Raw materials
Preparation Products
MC180295 Suppliers
Global( 25)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
Shanghai Jiyi Biological Technology Co., LTD | 021-54135696 18516235431 | shgegenetech@163.com | China | 986 | 55 |
ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | sales-cpd@caerulumpharma.com | China | 3423 | 58 |
Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7892 | 56 |
ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8011 | 62 |
Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9730 | 58 |
DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9414 | 58 |
MC180295 ((REL)-MC180295)
MC180295
MC-180295;MC 180295
(rel)-MC180295
Methanone, [4-amino-2-[(1R,2R,4S)-bicyclo[2.2.1]hept-2-ylamino]-5-thiazolyl](2-nitrophenyl)-, rel-
MC180295,MC 180295,Cyclin dependent kinase,MC-180295,CDK,inhibit,Inhibitor
2237942-08-2