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Astragaloside IV

CAS No.
83207-58-3
Chemical Name:
Astragaloside IV
Synonyms
Astragaloside IV;Astramembrannin i;Astragalin A;astragaloside A;Astragaloside IV;Astragaloside A 5%;ASTRAGALOSIDE IV(P);Astragaloside IV(A);Astragaloside IV CRS;Astragaloside IV ,98%
CBNumber:
CB0500944
Molecular Formula:
C41H68O14
Molecular Weight:
784.97
MDL Number:
MFCD00210476
MOL File:
83207-58-3.mol
MSDS File:
SDS
Last updated:2024-07-04 21:45:01

Astragaloside IV Properties

Boiling point 895.7±65.0 °C(Predicted)
Density 1.39±0.1 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility DMF: 20 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml
form A crystalline solid
pka 12.91±0.70(Predicted)
InChIKey QMNWISYXSJWHRY-APZLXCBQNA-N
LogP 0.628 (est)
CAS DataBase Reference 83207-58-3
FDA UNII 3A592W8XKE

SAFETY

Risk and Safety Statements

HS Code  29389090

Astragaloside IV price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 16677 Astragaloside A ≥98% 83207-58-3 1mg $57 2024-03-01 Buy
Cayman Chemical 16677 Astragaloside A ≥98% 83207-58-3 5mg $233 2024-03-01 Buy
Cayman Chemical 16677 Astragaloside A ≥98% 83207-58-3 10mg $412 2024-03-01 Buy
Cayman Chemical 16677 Astragaloside A ≥98% 83207-58-3 50mg $1092 2024-03-01 Buy
TRC A790125 AstragalosideA 83207-58-3 1mg $45 2021-12-16 Buy
Product number Packaging Price Buy
16677 1mg $57 Buy
16677 5mg $233 Buy
16677 10mg $412 Buy
16677 50mg $1092 Buy
A790125 1mg $45 Buy

Astragaloside IV Chemical Properties,Uses,Production

Uses

Astragalosides are bioactive saponins isolated from dried roots of plants of the genus Astragalus, which is used in traditional Chinese medicine. Astragaloside A, also known as astragaloside IV, is known to have diverse protective effects for the cardiovascular, immune, digestive, and nervous systems. More specifically, it protects cardiomyocytes from apoptosis resulting from ischemia/reperfusion and inhibits inflammation signaled through TNF-α. Furthermore, astragaloside A stimulates angiogenesis, promotes the differentiation of neural stem cells, and increases neuroregeneration.

Definition

ChEBI: A pentacyclic triterpenoid that is cycloastragenol having beta-D-xylopyranosyl and beta-D-glucopyranosyl residues attached at positions O-3 and O-6 respectively. It is isolated from <ital Astragalus membranaceus var mongholicus.

benefits

Astragaloside A (Astragaloside IV) is the primary pure saponin isolated from Astragalus membranaceus, which has been widely used for the treatment of cardiovascular diseases. It is the primary pure saponin isolated from Astragalus membranaceus, which has been widely used for the treatment of cardiovascular diseases. Astragaloside IV improves post-ischemic heart function and ameliorated reperfusion arrhythmias accompanied by a significant increase in myocardial antioxidative enzyme superoxide dismutase activity in rat hearts in vitro. While, Astragaloside IV's protective effect on heart function can be partially abrogated by the nitric oxide synthase inhibitor, Nomega-nitro-L-arginine methyl ester.

Health effects

As the main active ingredient of the Chinese medicine Astragalus membranaceus, Astragaloside A has a good regulatory effect on the heart. It can protect against ischemic and hypoxic cardiomyocytes, protect the heart structure, and enhance heart function.

Pharmaceutical Applications

Astrageloside A has multiple pharmacologic effects, including anti-inflammatory, antifibrotic, antioxidative stress, anti-asthma, antidiabetes, immunoregulation, and cardioprotective effect via numerous signaling pathways. According to the existing studies and clinical practices, Astragaloside A possesses potential for broad application in many diseases.

Mode of action

Astragaloside IV is a well-known AM compound known for its neuroprotective effects. It acts as an antioxidant and reduces cell inflammation and oxidative stress. Astragaloside IV helps protect dopaminergic neurons and promotes neural process outgrowth, potentially therapeutic in PD. All the benefits of this compound for neurodegenerative diseases such as AD, PD, cerebral ischemia, and autoimmune encephalomyelitis. AS-IV maintains dopamine synthesis by increasing enzymes tyrosine hydroxylase (TH) and nitric oxide synthase (NOS), which are involved in neuron production pathways, neural signalling, and cell immune responses. The other mechanism of AS-IV in PD disease is the prevention of neuron pathology by a neurotoxicant called 1-methyl-4-phenylpyridium ion (MPP+) throughout the increasing cell survival, inhibiting pro-apoptosis Bax-mediated pathway and caspase protein (Caspase-3) activity which can destroy cellular structures while increasing anti-apoptosis B-cell lymphoma 2 (Bcl-2). It also protects neuron mitochondria from apoptosis and DNA damage by inducing Akt to promote binding of hexokinase-II (HK-II) and mitochondria for the protection of neural mitochondria[1].

References

[1] Veit Ny . “Potential benefits of incorporating Astragalus membranaceus into the diet of people undergoing disease treatment: An overview.” Journal of Functional Foods 77 (2021): Article 104339.

Astragaloside IV Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 187)Suppliers
Supplier Tel Email Country ProdList Advantage
Nanjing Sky Hope Tongyuan Biological Engineering Co., Ltd.
+86-0086-025-69916489 +86-18852044786 tongyuansales@vip.sina.com China 323 58
Changsha Staherb Natural Ingredients Co., Ltd.
+86-0731-84213302 +86-18374838656 info@staherb.cn China 1025 58
Chengdu King-tiger Pharm-chem. Tech. Co., Ltd.
028-85317716 18202897410 sales@king-tiger.com China 6 58
Hebei Kingfiner Technology Development Co.Ltd
+86-15532196582 +86-15373005021 lisa@kingfinertech.com China 2990 58
Shaanxi Haibo Biotechnology Co., Ltd
+undefined18602966907 qinhe02@xaltbio.com China 1000 58
Henan Fengda Chemical Co., Ltd
+86-371-86557731 +86-13613820652 info@fdachem.com China 20293 58
Shaanxi TNJONE Pharmaceutical Co., Ltd
+8618740459177 sarah@tnjone.com China 1143 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21667 55
Hangzhou FandaChem Co.,Ltd.
008657128800458; +8615858145714 fandachem@gmail.com China 9354 55
NanJing Spring & Autumn Biological Engineering CO., LTD.
+8613815430202 sale02@cqherb.com CHINA 376 58

View Lastest Price from Astragaloside IV manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Astragaloside IV pictures 2024-09-19 Astragaloside IV
83207-58-3
US $7.00-4600.00 / g 10g 1%-98% 100 Chengdu King-tiger Pharm-chem. Tech. Co., Ltd.
AstragalosideIV pictures 2024-09-19 AstragalosideIV
83207-58-3
US $0.00-0.00 / kg 1kg 98% 1000 Changsha Staherb Natural Ingredients Co., Ltd.
Astragaloside A pictures 2024-06-24 Astragaloside A
83207-58-3
US $0.00-0.00 / kg 1kg 0.99 50000kg Hebei Kingfiner Technology Development Co.Ltd
  • Astragaloside IV pictures
  • Astragaloside IV
    83207-58-3
  • US $7.00-4600.00 / g
  • 1%-98%
  • Chengdu King-tiger Pharm-chem. Tech. Co., Ltd.
  • AstragalosideIV pictures
  • AstragalosideIV
    83207-58-3
  • US $0.00-0.00 / kg
  • 98%
  • Changsha Staherb Natural Ingredients Co., Ltd.
  • Astragaloside A pictures
  • Astragaloside A
    83207-58-3
  • US $0.00-0.00 / kg
  • 0.99
  • Hebei Kingfiner Technology Development Co.Ltd
ASTRAGALOSIDE IV(P) astragaloside A Astragaloside IV ,98% Astragaloside IV(A) Astragaloside A(Astragaloside IV) beta-D-Glucopyranoside, (3beta,6alpha,16beta,24R)-20,24-epoxy-16,25-dihydroxy-3-(beta-D-xylopyranosyloxy)-9,19-cyclolanostan-6-yl β-D-Glucopyranoside, (3β,6α,16β,24R)-20,24-epoxy-16,25-dihydroxy-3-(β-D-xylopyranosyloxy)-9,19-cyclolanostan-6-yl Astragalus Extract Astragaloside IV Astragaloside IV-Astragaloside A Astragaloside IV CRS Astragalin A Astragaloside A USP/EP/BP Astragaloside A 5% b-D-Glucopyranoside, (3b,6a,16b,24R)-20,24-epoxy-16,25-dihydroxy-3-(b-D-xylopyranosyloxy)-9,19-cyclolanostan-6-yl Astragaloside A (Astramembrannin I Astragaloside IV Astramembrannin i astragalus polysaccharide concentrated extract Astragalus methylside (2R,3R,4S,5S,6R)-2-(((2aR,3R,4S,5aS,5bS,7S,7aR,9S,11aR,12aS)-4-Hydroxy-3-((2S,5R)-5-(2-hydroxypropan-2-yl)-2-methyltetrahydrofuran-2-yl)-2a,5a,8,8-tetramethyl-9-(((2S,3R,4S,5R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)hexadecahydrocyclopenta[a]cyclopropa[e]phenanthren-7-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol Astragaloside IV 83207-58-3 Inhibitors API Plant extracts