Phenyl-4-aminosalicylate
- CAS No.
- 133-11-9
- Chemical Name:
- Phenyl-4-aminosalicylate
- Synonyms
- FR 7;Tebamin;Tebanyl;fenamisal;NSC-40144;PHENYL PAS;p-Aminosalol;Pheny-PAS-Tebamin;Phenyl-PAS-Tebamin;TIMTEC-BB SBB000692
- CBNumber:
- CB0734217
- Molecular Formula:
- C13H11NO3
- Molecular Weight:
- 229.23
- MDL Number:
- MFCD00007788
- MOL File:
- 133-11-9.mol
| Melting point | 150-152 °C(lit.) |
|---|---|
| Boiling point | 371.13°C (rough estimate) |
| Density | 1.2084 (rough estimate) |
| refractive index | 1.5500 (estimate) |
| storage temp. | -20°C Freezer |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 8.76±0.10(Predicted) |
| form | Solid |
| color | Off-White |
| CAS DataBase Reference | 133-11-9(CAS DataBase Reference) |
| FDA UNII | 52936SIP7V |
| EPA Substance Registry System | Phenyl 4-aminosalicylate (133-11-9) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319-H315-H335 | |||||||||
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
Phenyl-4-aminosalicylate price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | P309020 | Phenyl4-Aminosalicylate | 133-11-9 | 250mg | $150 | 2021-12-16 | Buy |
| Usbiological | 462417 | Phenyl 4-Aminosalicylate | 133-11-9 | 250mg | $460 | 2021-12-16 | Buy |
| TRC | P309020 | Phenyl4-Aminosalicylate | 133-11-9 | 2.5g | $1190 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 48190 | Phenyl4-Aminosalicylate | 133-11-9 | 250mg | $650 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0031749 | PHENYL 4-AMINOSALICYLATE 95.00% | 133-11-9 | 1G | $655.91 | 2021-12-16 | Buy |
Phenyl-4-aminosalicylate Chemical Properties,Uses,Production
Chemical Properties
WHITE POWDER
Originator
Pheny-Pas-Teb-Amin ,Purdue Frederick, US,1959
Uses
Antibacterial(tuberculostatic).
Uses
Phenyl 4-Aminosalicylate is a reactant in the synthesis of p-aminosalicylic ester imines with antitubercular activity.
Definition
ChEBI: 4-amino-2-hydroxybenzoic acid phenyl ester is a carbonyl compound.
Manufacturing Process
183 g of p-nitrosalicylic acid are dissolved in 564 g of phenol by heating to 140°C to 150°C on an oil bath. When all the p-nitrosalicylic acid is dissolved, 153 g of phosphorus oxychloride are run in, drop by drop, over a period of about 2 hours, while maintaining the temperature at about 150°C. The still warm mixture is run into 2 liters of water with agitation. The precipitate formed is filtered off, washed with water until phenol is removed and then dried.
There are thus obtained 250 g of 2-hydroxy-4-nitrophenylbenzoate which melts at 154°C to 155°C.
In a hydrogenation autoclave are introduced 92 g of 2-hydroxy-4nitrophenylbenzoate preceded by 200 cc of ethyl acetate; Raney nickel, obtained from 30 g of alloy, is added with 300 cc of ethyl acetate. Hydrogenation under pressure (100 to 120 kg) at ordinary temperature is carried out during a period of about 12 hours. The nickel is filtered off and the ethyl acetate is removed by distillation on the water bath under a vacuum of 300 mm. There is thus obtained 80 g of crude damp 2-hydroxy-4amnophenylbenzoate which after recrystallization from isopropyl alcohol melts at 153°C.
brand name
Pheny-Pas-Tebamin (Purdue Frederick).
Therapeutic Function
Antibacterial (tuberculostatic)
Purification Methods
Crystallise the ester from EtOH (m 155o, also 149-150.5o), aqueous EtOH (m 147-149o), or isopropanol. It is tuberculostatic.[Beilstein 13 IV 1979.]
Phenyl-4-aminosalicylate Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
Phenyl-4-aminosalicylate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
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