Chalcone
- CAS No.
- 94-41-7
- Chemical Name:
- Chalcone
- Synonyms
- (E)-CHALCONE;BENZALACETOPHENONE;CHALKONE;1,3-DIPHENYL-2-PROPENONE;CHALCONE;CHALCONE;AI3-00946;NSC 26612;CCRIS 2213;Chalcone b
- CBNumber:
- CB0746254
- Molecular Formula:
- C15H12O
- Molecular Weight:
- 208.26
- MDL Number:
- MFCD00003082
- MOL File:
- 94-41-7.mol
- MSDS File:
- SDS
| Melting point | 55-59 °C |
|---|---|
| Boiling point | 208 °C25 mm Hg(lit.) |
| Density | d462 1.0712 |
| refractive index | nD62 1.6458 |
| Flash point | >230 °F |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | dioxane: soluble1g/10 mL, clear, colorless |
| form | Granular Powder |
| color | Yellow |
| Merck | 14,2037 |
| BRN | 1210466 |
| LogP | 3.080 |
| CAS DataBase Reference | 94-41-7(CAS DataBase Reference) |
| FDA UNII | 5S5A2Q39HX |
| EPA Substance Registry System | 2-Propen-1-one, 1,3-diphenyl- (94-41-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H302-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-36/37 | |||||||||
| Safety Statements | 22-36/37/39-45 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UD5576750 | |||||||||
| HS Code | 29143900 | |||||||||
| NFPA 704 |
|
Chalcone price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 11970 | 1,3-Diphenyl-2-propenone ≥98.0% (GC) | 94-41-7 | 100g | $71.1 | 2023-06-20 | Buy |
| TCI Chemical | C0071 | Chalcone >98.0%(GC) | 94-41-7 | 25g | $31 | 2024-03-01 | Buy |
| TCI Chemical | C0071 | Chalcone >98.0%(GC) | 94-41-7 | 100g | $82 | 2024-03-01 | Buy |
| TCI Chemical | C0071 | Chalcone >98.0%(GC) | 94-41-7 | 500g | $200 | 2024-03-01 | Buy |
| TRC | C291855 | Chalcone | 94-41-7 | 250g | $365 | 2021-12-16 | Buy |
Chalcone Chemical Properties,Uses,Production
Description
Chalcone is the organic compound C6H5C(O)CH=CHC6H5. It is an α,β-unsaturated ketone. A variety of important biological compounds are known collectively as chalcones or chalconoids.They show antibacterial, antifungal, antitumor and anti-inflammatory properties. They are also intermediates in the biosynthesis of flavonoids, which are substances widespread in plants and with an array of biological activities. Chalcones are also intermediates in the Auwers synthesis of flavones.
Chemical Properties
light yellow powder
Uses
1,3-Diphenyl-2-propenone was used in the preparation of pharmacologically-interesting heterocyclic systems like pyrazolines and pyrimidines.
Uses
Chalcone is used in the preparation of pharmacologically-interesting heterocyclic systems like pyrazolines and pyrimidines. It also inhibits the proliferation of human breast cancer cell lines, MCF-7 and MDA-MB-231 by inducing apoptosis and blocking cell cycle progression in the G2/M phase.
Definition
ChEBI: A member of the class of chalcones that is acetophenone in which one of the methyl hydrogens has been replaced by a benzylidene group.
Preparation
Chalcone is an aromatic ketone that forms the central core for a variety of important biological compounds, which are known collectively as chalcones.
Chalcones can be prepared by an aldol condensation between a benzaldehyde and an acetophenone in the presence of sodium hydroxide as a catalyst.
This reaction has been found to work without any solvent at all - a solid-state reaction. The reaction between substituted benzaldehydes and acetophenones has been used to demonstrate green chemistry in undergraduate chemistry education.In a study investigating green chemistry synthesis, chalcones were also synthesized from the same starting materials in high temperature water (200 to 350 °C).
Biological Activity
1,3-Diphenyl-2-propenone (chalcone) inhibits the proliferation of human breast cancer cell lines, MCF-7 and MDA-MB-231 by inducing apoptosis and blocking cell cycle progression in the G2/M phase. It is an inhibitor of Plasmodium falciparum cyclin-dependent protein kinases.
Biochem/physiol Actions
1,3-Diphenyl-2-propenone (chalcone) inhibits the proliferation of human breast cancer cell lines, MCF-7 and MDA-MB-231 by inducing apoptosis and blocking cell cycle progression in the G2/M phase. It is an inhibitor of Plasmodium falciparum cyclin-dependent protein kinases.
Safety Profile
Poison by intravenous route. See also KETONES. When heated to decomposition it emits acrid smoke and irritating fumes.
Purification Methods
Crystallise it from EtOH by warming to 50o (about 5mL/g), iso-octane, or toluene/pet ether, or recrystallise it from MeOH, and then twice from hexane. SKIN IRRITANT. [Beilstein 7 IV 1658.]
Chalcone Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 7786 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| zhangjiagang vinsce bio-pharm. limited. | 86-512-58389969 | sales1@swellxin.com | CHINA | 111 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
| XI'AN TIANGUANGYUAN BIOTECH CO., LTD. | +86-029-86333380 18829239519 | sales06@tgybio.com | China | 961 | 58 |
View Lastest Price from Chalcone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-09 | Chalcone
94-41-7
|
US $8.00-1.00 / KG | 1KG | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2023-10-26 | Chalcone
94-41-7
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | |
 |
2023-09-06 | Chalcone
94-41-7
|
US $0.00 / KG | 1KG | 99% | 500000kg | Hebei Guanlang Biotechnology Co., Ltd. |
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