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2,6-Piperidinedione, 3-(1,3-dihydro-4-iodo-1-oxo-2H-isoindol-2-yl)-

2,6-Piperidinedione, 3-(1,3-dihydro-4-iodo-1-oxo-2H-isoindol-2-yl)- structure

CAS No.: 2207541-30-6

Chemical Name:: 2,6-Piperidinedione, 3-(1,3-dihydro-4-iodo-1-oxo-2H-isoindol-2-yl)-

Synonyms: Lenalidomide-I;3-(4-iodo-1-oxoisoindolin-2-yl)piperidine-2,6-dione;2,6-Piperidinedione, 3-(1,3-dihydro-4-iodo-1-oxo-2H-isoindol-2-yl)-

CBNumber:: CB08182416

Molecular Formula:: C13H11IN2O3

Molecular Weight:: 370.14

MDL Number:

MOL File:: 2207541-30-6.mol

Last updated:2023-04-23 13:52:06

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2,6-Piperidinedione, 3-(1,3-dihydro-4-iodo-1-oxo-2H-isoindol-2-yl)- Properties

Boiling point	601.2±55.0 °C(Predicted)
Density	1.876±0.06 g/cm3(Predicted)
solubility	DMSO : 25 mg/mL (67.54 mM; Need ultrasonic)
pka	10.67±0.40(Predicted)

2,6-Piperidinedione, 3-(1,3-dihydro-4-iodo-1-oxo-2H-isoindol-2-yl)- Chemical Properties,Uses,Production

Biological Activity

Lenalidomide-I (Compound 72), an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, is used in the recruitment of CRBN protein. Lenalidomide-I can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC BET degrader QCA570 [1]. Lenalidomide-I can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].

References

[1]. Qin C, et, al. Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression. J Med Chem. 2018 Aug 9;61(15):6685-6704.

2,6-Piperidinedione, 3-(1,3-dihydro-4-iodo-1-oxo-2H-isoindol-2-yl)- Preparation Products And Raw materials

Raw materials

Preparation Products

2,6-Piperidinedione, 3-(1,3-dihydro-4-iodo-1-oxo-2H-isoindol-2-yl)- Suppliers

Global( 22)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanxi Xuanran Import and Export Trade Co., Ltd.	+8617735180244	mike_yan@xuanranglobal.com	CHINA	4022	58
Shanxi Tihondan Pharmaceutical Technology Co., Ltd	+8618235132063	sales@tihondan.com	China	3725	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	+8613720134139	orders@jknbiochem.com	China	4692	58
Abosyn	0512-69561983 13914027025	he_qf@medinoah.com	China	3001	58
SHANGHAI FDC-CHEMICAL CO.,LTD	021-61469567 18521078705	sales@fdc-chemical.com	China	19947	58
SuZhou Medinoah Co.,LTD.	0512-0512-69561983 13914027025	he_qf@medinoah.com	China	3418	58
Jilin Province Woda Biotechnology Co., Ltd.	13504435624	1927928688@qq.com	China	1360	58
Shanghai Amico Chemicals Co. LTD	18019252918	sale@amkchem.com	China	15015	58
Shanghai Subo Pharmaceutical Technology Co., Ltd.	021-54156369 16621315851	yhsuyiming@126.com	China	306	58
Shanghai Chino Pharmaceutical Technology Co., Ltd	021-021-51557188 15901710861	sales@channelpharm.com	China	1098	58

Supplier	Advantage
Shanxi Xuanran Import and Export Trade Co., Ltd.	58
Shanxi Tihondan Pharmaceutical Technology Co., Ltd	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	58
Abosyn	58
SHANGHAI FDC-CHEMICAL CO.,LTD	58
SuZhou Medinoah Co.,LTD.	58
Jilin Province Woda Biotechnology Co., Ltd.	58
Shanghai Amico Chemicals Co. LTD	58
Shanghai Subo Pharmaceutical Technology Co., Ltd.	58
Shanghai Chino Pharmaceutical Technology Co., Ltd	58

2,6-Piperidinedione, 3-(1,3-dihydro-4-iodo-1-oxo-2H-isoindol-2-yl)- 3-(4-iodo-1-oxoisoindolin-2-yl)piperidine-2,6-dione Lenalidomide-I 2207541-30-6