CDK1/2InhibitorIII
- CAS No.
- 443798-55-8
- Chemical Name:
- CDK1/2InhibitorIII
- Synonyms
- 2 Inhibitor III;CDK1/2InhibitorIII;Cdk-1/2 Inhibitor III,Cdk1/2 Inhibitor III;5-amino-N-(2,6-difluorophenyl)-3-(4-sulfamoylanilino)-1,2,4-triazole-1-carbothioamide;1H-1,2,4-Triazole-1-carbothioamide, 3-amino-5-[[4-(aminosulfonyl)phenyl]amino]-N-(2,6-difluorophenyl)-
- CBNumber:
- CB11113964
- Molecular Formula:
- C15H13F2N7O2S2
- Molecular Weight:
- 425.44
- MDL Number:
- MOL File:
- 443798-55-8.mol
- MSDS File:
- SDS
CDK1/2InhibitorIII price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 217714 | Cdk1/2 Inhibitor III - CAS 443798-55-8 - Calbiochem | 443798-55-8 | 1MG | $140 | 2023-06-20 | Buy |
| Cayman Chemical | 18859 | Cdk1/2 Inhibitor III ≥95% | 443798-55-8 | 1mg | $79 | 2021-12-16 | Buy |
| Cayman Chemical | 18859 | Cdk1/2 Inhibitor III ≥95% | 443798-55-8 | 5mg | $315 | 2021-12-16 | Buy |
| Cayman Chemical | 18859 | Cdk1/2 Inhibitor III ≥95% | 443798-55-8 | 10mg | $475 | 2021-12-16 | Buy |
| TRC | C228110 | CDK1/2InhibitorIII | 443798-55-8 | 1mg | $90 | 2021-12-16 | Buy |
CDK1/2InhibitorIII Chemical Properties,Uses,Production
Uses
Cyclin-dependent kinases (CDKs) are protein kinases and involved with the regulation of the cell cycle. CDK 1/2 inhibitor III selectively inhibits CDK1 and CDK2. Studies have shown that CDK 1/2 Inhibitor III can also inhibit in vitro cellular proliferation in various human tumor cells.
Uses
Cyclin-dependent kinases (Cdks) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. Cdk1/2 Inhibitor III is a cell-permeable inhibitor of Cdk1/cyclin B and Cdk2/cyclin A (IC50s = 0.6 and 0.5 nM, respectively). It less potently inhibits CDC2-like kinases 1 and 3, VEGFR2, and GSK-3β (IC50s = 8.9, 29, 32, and 140 nM, respectively) and is without effect against a panel of other kinases. Cdk1/2 Inhibitor III blocks the growth of several cancer cell lines (IC50 values range from 20 to 92 nM).
General Description
A cell-permeable triazolo-diamine compound that displays anti-proliferative properties in various human cancer cells (IC50 = 20 nM, 35 nM and 92 nM in HCT-116, HeLa, and A375 cells, respectively). Acts as a highly potent, reversible, ATP-competitive inhibitor of Cdk1/cyclin B and Cdk2/cyclin A (IC50 = 600 pM and 500 pM, respectively) with selectivity over VEGF-R2 (IC50 = 32 nM), GSK-3β (IC50 = 140 nM), and a panel of eight other kinases (IC50 ≥ 1 μM).
Biochem/physiol Actions
Cell permeable: yes
CDK1/2InhibitorIII Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9708 | 58 |
| DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9412 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
| cjbscvictory | 13348960310 13348960310 | 3003867561@qq.com | China | 10011 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24017 | 58 |
| Nantong Hanfang Biotechnology Co. , Ltd. | 3674309880 | hanfangpharma@126.com | China | 30968 | 58 |
| United States Biological | -- | sales@advtechind.com | United States | 6106 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| Aladdin Scientific | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 58 |
| DC Chemicals | 58 |
| Energy Chemical | 58 |
| cjbscvictory | 58 |
| TargetMol Chemicals Inc. | 58 |
| Nantong Hanfang Biotechnology Co. , Ltd. | 58 |
| United States Biological | 58 |