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ChemicalBook >> CAS DataBase List >>Acetamide, 2-chloro-N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]-

Acetamide, 2-chloro-N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]-

Acetamide, 2-chloro-N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]- Structure
Acetamide, 2-chloro-N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]- structure
CAS No.
2248703-42-4
Chemical Name:
Acetamide, 2-chloro-N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]-
Synonyms
SACLAC;Acetamide, 2-chloro-N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]-
CBNumber:
CB112280479
Molecular Formula:
C20H40ClNO3
Molecular Weight:
377.99
MDL Number:
MOL File:
2248703-42-4.mol
Last updated:2023-05-21 10:59:17
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Acetamide, 2-chloro-N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]- Properties

Boiling point 560.1±50.0 °C(Predicted)
Density 1.016±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility Chloroform: soluble
form A solid
pka 13.01±0.46(Predicted)

Acetamide, 2-chloro-N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]- Chemical Properties,Uses,Production

Biological Activity

SACLAC is an irreversible inhibitor of acid ceramidase (Ki = 97.1 nM) and a derivative of the acid ceramidase inhibitor SABRAC .1 It decreases levels of sphingosine-1-phosphate (S1P) and increases total ceramide levels in OCI-AML-2 acute myeloid leukemia (AML) cells when used at a concentration of 2.5 μM.2 SACLAC (10 and 20 μM) induces apoptosis in primary AML cells. It reduces leukemic burden in MV4-11 and U937 AML mouse xenograft models when administered at a dose of 5 mg/kg.

References

1.Ordó?ez, Y.F., Abad, J.L., Aseeri, M., et al.Activity-based imaging of acid ceramidase in living cellsJ. Am. Chem. Soc.141(19)7736-7742(2019) 2.Pearson, J.M., Tan, S.-F., Sharma, A., et al.Ceramide analogue SACLAC modulates sphingolipid levels and MCL-1 splicing to induce apoptosis in acute myeloid leukemiaMol. Cancer Res.18(3)352-363(2020)

Acetamide, 2-chloro-N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

Acetamide, 2-chloro-N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]- Suppliers

Global( 5)Suppliers
Supplier Tel Email Country ProdList Advantage
Zhengzhou Convergence Chemical Co. LTD 0371-53736046 13393710386 2853979814@qq.com China 10008 58
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581 sales@chemhifuture.com China 4164 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 8740 58
Wuhan Acumen Bio-Technology Co.,ltd 027-027-16602739303 16602739303 673003916@qq.com China 2919 58
Supplier Advantage
Zhengzhou Convergence Chemical Co. LTD 58
Nantong QuanYi Biotechnology Co., Ltd 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
Wuhan Acumen Bio-Technology Co.,ltd 58
Acetamide, 2-chloro-N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]- SACLAC 2248703-42-4