ChemicalBook >> CAS DataBase List >>Acetamide, 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-N-[2-[2-[2-[4-[5-[2-[2-methyl-5-(1-methylethyl)phenoxy]-4-pyrimidinyl]-4-[4-(trifluoromethyl)phenyl]-1H-imidazol-1-yl]-1-piperidinyl]ethoxy]ethoxy]ethyl]-

Acetamide, 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-N-[2-[2-[2-[4-[5-[2-[2-methyl-5-(1-methylethyl)phenoxy]-4-pyrimidinyl]-4-[4-(trifluoromethyl)phenyl]-1H-imidazol-1-yl]-1-piperidinyl]ethoxy]ethoxy]ethyl]-

Acetamide, 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-N-[2-[2-[2-[4-[5-[2-[2-methyl-5-(1-methylethyl)phenoxy]-4-pyrimidinyl]-4-[4-(trifluoromethyl)phenyl]-1H-imidazol-1-yl]-1-piperidinyl]ethoxy]ethoxy]ethyl]- structure

CAS No.: 2839318-19-1

Chemical Name:: Acetamide, 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-N-[2-[2-[2-[4-[5-[2-[2-methyl-5-(1-methylethyl)phenoxy]-4-pyrimidinyl]-4-[4-(trifluoromethyl)phenyl]-1H-imidazol-1-yl]-1-piperidinyl]ethoxy]ethoxy]ethyl]-

Synonyms: dBRD4-BD1;Acetamide, 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-N-[2-[2-[2-[4-[5-[2-[2-methyl-5-(1-methylethyl)phenoxy]-4-pyrimidinyl]-4-[4-(trifluoromethyl)phenyl]-1H-imidazol-1-yl]-1-piperidinyl]ethoxy]ethoxy]ethyl]-

CBNumber:: CB112280499

Molecular Formula:: C50H53F3N8O9

Molecular Weight:: 967

MDL Number:

MOL File:: 2839318-19-1.mol

Last updated:2023-03-31 09:12:57

Request For Quotation

Acetamide, 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-N-[2-[2-[2-[4-[5-[2-[2-methyl-5-(1-methylethyl)phenoxy]-4-pyrimidinyl]-4-[4-(trifluoromethyl)phenyl]-1H-imidazol-1-yl]-1-piperidinyl]ethoxy]ethoxy]ethyl]- Properties

Density	1.41±0.1 g/cm3(Predicted)
pka	10.68±0.40(Predicted)

Acetamide, 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-N-[2-[2-[2-[4-[5-[2-[2-methyl-5-(1-methylethyl)phenoxy]-4-pyrimidinyl]-4-[4-(trifluoromethyl)phenyl]-1H-imidazol-1-yl]-1-piperidinyl]ethoxy]ethoxy]ethyl]- Chemical Properties,Uses,Production

Description

dBRD4-BD1 is a selective BRD4 bromodomain inhibitor. dBRD4-BD1 can selectively degrade BRD4 (DC50 = 280 nM). Notably, dBRD4-BD1 upregulates BRD2/3, a result not observed with degraders using pan-BET ligands. Designing BRD4 selectivity up front enables analysis of BRD4 biology without wider BET-inhibition and simplifies designing BRD4-selective heterobifunctional molecules, such as degraders with new E3 recruiting ligands or for additional probes beyond degraders.

Acetamide, 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-N-[2-[2-[2-[4-[5-[2-[2-methyl-5-(1-methylethyl)phenoxy]-4-pyrimidinyl]-4-[4-(trifluoromethyl)phenyl]-1H-imidazol-1-yl]-1-piperidinyl]ethoxy]ethoxy]ethyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

Acetamide, 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-N-[2-[2-[2-[4-[5-[2-[2-methyl-5-(1-methylethyl)phenoxy]-4-pyrimidinyl]-4-[4-(trifluoromethyl)phenyl]-1H-imidazol-1-yl]-1-piperidinyl]ethoxy]ethoxy]ethyl]- Suppliers

Global( 2)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Nantong QuanYi Biotechnology Co., Ltd	0513-66337626 18051384581	sales@chemhifuture.com	China	4164	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.com	China	24246	58

Supplier	Advantage
Nantong QuanYi Biotechnology Co., Ltd	58
TargetMol Chemicals Inc.	58