Fudosteine
- CAS No.
- 13189-98-5
- Chemical Name:
- Fudosteine
- Synonyms
- FUDESTEINE;FUDOSTEINE;fodosteine;Fu si temple;Fudosteine99%;Fudosteine USP/EP/BP;Fudosteine Impurities1413;S-(3-HYDROXYPROPYL)CYSTEINE;s-(3-hydroxypropyl)-l-cystein;s-(3-hydroxypropyl)-l-cysteine
- CBNumber:
- CB1128341
- Molecular Formula:
- C6H13NO3S
- Molecular Weight:
- 179.24
- MDL Number:
- MFCD00899873
- MOL File:
- 13189-98-5.mol
- MSDS File:
- SDS
| Melting point | 200-202°C (dec.) |
|---|---|
| Boiling point | 354.5±42.0 °C(Predicted) |
| Density | 1.301±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| solubility | Water (Slightly) |
| form | Solid |
| pka | 2.09±0.10(Predicted) |
| color | White to Light Brown |
| CAS DataBase Reference | 13189-98-5(CAS DataBase Reference) |
| FDA UNII | UR9VPI71PT |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| NFPA 704 |
|
Fudosteine price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 16722 | Fudosteine ≥95% | 13189-98-5 | 10mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 16722 | Fudosteine ≥95% | 13189-98-5 | 25mg | $63 | 2024-03-01 | Buy |
| Cayman Chemical | 16722 | Fudosteine ≥95% | 13189-98-5 | 50mg | $109 | 2024-03-01 | Buy |
| Cayman Chemical | 16722 | Fudosteine ≥95% | 13189-98-5 | 100mg | $199 | 2024-03-01 | Buy |
| TRC | H952575 | S-(3-Hydroxypropyl)-L-cysteine | 13189-98-5 | 500mg | $580 | 2021-12-16 | Buy |
Fudosteine Chemical Properties,Uses,Production
Description
Fudostein was launched in Japan as a new mucoactive agent for the treatment of bronchitis and respiratory congestion. This cysteine derivative was obtained from L-cysteine by condensation with either allylic alcohol in the presence of potassium persulfate or the corresponding bromoalcohol in the presence of a base. Fudostein was shown to significantly reduce mucus glycoprotein hypersecretion and inhibit infiltration of airway mucosa by lymphocytes and inflammatory cells in bronchitic rats. When given to bronchitic rabbits, an oral dose of 500 mg/kg daily potently decreased the fucose/ N-acetylneuraminic acid in sputa, so exhibiting mucoregulatory properties. In another study with SO2-exposed rabbits, fudostein suppressed blood flow of tracheal microvasculature increased by SO2, partly due to scavenging of superoxide anion.
Description
Fudosteine is a cysteine derivative that interferes with the increase in goblet cell number, expression of the mucin MUC5AC, and subsequent mucin secretion, in airways agonized with tobacco smoke, isoproterenol, lipopolysaccharide, TNF-α, or oxidants. Fudosteine, which is a thiol compound with antioxidant properties, limits NF-κB signaling and reduces inflammatory gene expression. It has greater bioavailability than N-acetyl-cysteine and increases cysteine levels in cells.
Chemical Properties
Off-White Powder
Originator
SS Pharmaceutical/Mitsubishi Pharma (Japan)
Uses
Fudosteine is a cysteine derivative that interferes with the increase in goblet cell number, expression of the mucin MUC5AC, and subsequent mucin secretion, in airways agonized with tobacco smoke, isoproterenol, lipopolysaccharide, TNF-α, or oxidants. Fudosteine, which is a thiol compound with antioxidant properties, limits NF-κB signaling and reduces inflammatory gene expression. It has greater bioavailability than N-acetyl-cysteine and increases cysteine levels in cells.
Uses
A demonstrated antiinflammatory
Uses
Fudosteine is a novel mucoactive agent and a MUC5AC mucin hypersecretion inhibitor. MUC5AC mucin synthesis and the expression of the MUC5AC gene were increased by LPS in rats or TNF-α in NCI-H292 cells; these effects were inhibited by fudosteine treatment
Uses
An antiinflammatory expectorant used in the treatment of MUC5 mucin obstructive pulmonary disease.
Uses
An antiinflammatory expectorant MUC5 mucin obstructive pulmonary disease.
Definition
ChEBI: Fudosteine is an organic molecular entity.
brand name
Cleanal, Spelear (Mitsubishi Pharma)
Hazard
A reproductive hazard.
Synthesis
Fudosteine is synthesized by condensation of L-cysteine with 3-bromopropyl alcohol in aqueous NaOH, or by condensation of L-cysteine with allyl alcohol by means of aqueous potassium persulfate.
Fudosteine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2504 | 58 |
| Ouhuang Engineering Materials (Hubei) Co., Ltd | +8617702722807 | admin@hbouhuang.com | China | 175 | 58 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| HubeiwidelychemicaltechnologyCo.,Ltd | 18627774460 | faith@widelychemical.com | CHINA | 742 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14336 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
View Lastest Price from Fudosteine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-16 | Fudosteine
13189-98-5
|
US $50.00 / kg | 1kg | 99.10% | 50000kg | Ouhuang Engineering Materials (Hubei) Co., Ltd | |
 |
2024-04-16 | Fudosteine
13189-98-5
|
US $50.00 / kg | 1kg | 99.10% | 50000kg | Ouhuang Engineering Materials (Hubei) Co., Ltd | |
 |
2024-04-16 | Fudosteine
13189-98-5
|
US $50.00 / kg | 1kg | 99.10% | 50000kg | Ouhuang Engineering Materials (Hubei) Co., Ltd |
-
- Fudosteine
13189-98-5
- US $50.00 / kg
- 99.10%
- Ouhuang Engineering Materials (Hubei) Co., Ltd
-
- Fudosteine
13189-98-5
- US $50.00 / kg
- 99.10%
- Ouhuang Engineering Materials (Hubei) Co., Ltd
-
- Fudosteine
13189-98-5
- US $50.00 / kg
- 99.10%
- Ouhuang Engineering Materials (Hubei) Co., Ltd