ChemicalBook >> CAS DataBase List >>4-METHOXYCINNAMIC ACID

4-METHOXYCINNAMIC ACID

CAS No.
943-89-5
Chemical Name:
4-METHOXYCINNAMIC ACID
Synonyms
PMCA;AKOS B000181;AKOS BB/0034;AKOS BBS-00000769;TIMTEC-BB SBB005717;RARECHEM BK HC T257;OTAVA-BB BB0123400502;4-Methoxycinnamic acid;LABOTEST-BB LT00108121;O-METHYL-P-CUMARIC ACID
CBNumber:
CB1152939
Molecular Formula:
C10H10O3
Molecular Weight:
178.18
MDL Number:
MFCD00004398
MOL File:
943-89-5.mol
MSDS File:
SDS
Last updated:2023-06-08 17:06:34

4-METHOXYCINNAMIC ACID Properties

Melting point 173.5 °C(lit.)
Boiling point 342.6±17.0 °C(Predicted)
Density 1.195±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Soluble in ethanol, ethyl acetate and other organic solvents.
pka 4.60±0.10(Predicted)
form powder to crystal
color White to Almost white
BRN 510468
InChIKey AFDXODALSZRGIH-QPJJXVBHSA-N
LogP 1.264 (est)
CAS DataBase Reference 943-89-5(CAS DataBase Reference)
FDA UNII 6G4ML8401A
NIST Chemistry Reference 2-Propenoic acid, 3-(4-methoxyphenyl)-, (e)-(943-89-5)
EPA Substance Registry System 2-Propenoic acid, 3-(4-methoxyphenyl)-, (2E)- (943-89-5)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-37/39
WGK Germany  3
RTECS  UD3391300
8
TSCA  Yes
HS Code  2918.29.7500
HazardClass  IRRITANT
NFPA 704
0
2 0

4-METHOXYCINNAMIC ACID price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical M0576 trans-4-Methoxycinnamic Acid >98.0%(GC)(T) 943-89-5 25g $31 2024-03-01 Buy
TCI Chemical M0576 trans-4-Methoxycinnamic Acid >98.0%(GC)(T) 943-89-5 100g $77 2024-03-01 Buy
Alfa Aesar A13870 trans-4-Methoxycinnamic acid 98% 943-89-5 10g $21.65 2024-03-01 Buy
Alfa Aesar A13870 trans-4-Methoxycinnamic acid 98% 943-89-5 50g $80.65 2024-03-01 Buy
Alfa Aesar A13870 trans-4-Methoxycinnamic acid 98% 943-89-5 250g $336.65 2024-03-01 Buy
Product number Packaging Price Buy
M0576 25g $31 Buy
M0576 100g $77 Buy
A13870 10g $21.65 Buy
A13870 50g $80.65 Buy
A13870 250g $336.65 Buy

4-METHOXYCINNAMIC ACID Chemical Properties,Uses,Production

Uses

Esters derived from trans-4-methoxycinnamic acid are effective absorbers of UV radiation. The starting material was trans-4-methoxycinnamic acid and 3,5dimethoxybenzoic acid methyl ester in isolated avenanthramide alkaloids synthsis. trans-4-Methoxycinnamic acid was converted into its acid chloride (yield 98%) with thionyl chloride. Employed in organic synthesis of pharmaceutical intermediates, synthetic anti-adrenergic drugs esmolol, cosmetics ultraviolet absorption.

Preparation

4-methoxycinnamic acid synthesis : In a 25-mL, roundbottomed flask, 4-methoxybenzaldehyde (0.804 mL, 6.61 mmol) (3), malonic acid (1.75 g, 16.8 mmol), and β-alanine (0.10 g, 1.12 mmol) were dissolved in pyridine (3.0 mL, 37.1 mmol) and heated under reflux for 90 minutes. After cooling to room temperature, the reaction mixture was placed in an ice bath and 8.0 mL of concentrated HCl was slowly added. The resulting white precipitate was collected by vacuum filtration, washed with cold water (2 x 10mL) and dried thoroughly. The product was recrystallized from absolute ethanol (~20 mL).Synthesis of 4-methoxycinnamic acid
Synthesis of 4-methoxycinnamic acid

Definition

ChEBI: 4-methoxycinnamic acid is a methoxycinnamic acid having a single methoxy substituent at the 4-position on the phenyl ring. It is functionally related to a cinnamic acid.

Purification Methods

Crystallise the acid from MeOH to constant melting point and UV spectrum. [Beilstein 10 IV 1005.]

141-82-2
123-11-5
943-89-5
Synthesis of 4-METHOXYCINNAMIC ACID from Malonic acid and p-Anisaldehyde
Global( 198)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Dalian Richfortune Chemicals Co., Ltd
0411-84820922 8613904096939 sales@richfortunechem.com China 302 57
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21703 55
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29919 58
Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28180 58
Hubei xin bonus chemical co. LTD
86-13657291602 linda@hubeijusheng.com CHINA 22968 58
Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
Shaanxi Dideu Medichem Co. Ltd
18192627656 1012@dideu.com China 3911 58
Dayang Chem (Hangzhou) Co.,Ltd.
571-88938639 +8617705817739 info@dycnchem.com CHINA 52867 58
CR Corporation Lomited
fred.wen@crcorporation.cn CHINA 12069 58

View Lastest Price from 4-METHOXYCINNAMIC ACID manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-methoxycinnamicacid pictures 2023-03-27 4-methoxycinnamicacid
943-89-5
US $25.00 / KG 1KG 0.99 20 tons XINGTAI XINGJIU NEW MATERIAL TECHNOLOGY CO., LTD
4-METHOXYCINNAMIC ACID pictures 2021-08-12 4-METHOXYCINNAMIC ACID
943-89-5
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
(E)-4-Methoxycinnamic Acid pictures 2021-07-09 (E)-4-Methoxycinnamic Acid
943-89-5
US $16.00 / KG 1KG 99.9% 20tons/day Hebei Xibaijie Biotechnology Co., Ltd.
4-METHOXYCINNAMIC ACID ABOUT 98% trans-4-Methoxycinnamic acid, 98+% (E)-4-Methoxycinnamic acid 4-Methoxy-trans-cinnamic acid p-Methoxy-trans-cinnamic acid 4-Methoxycinnamic acid >=98.0% (GC) trans-4-MethoxyClnnamic acid 4-Methoxycinnamic acid RARECHEM BK HC T257 TIMTEC-BB SBB005717 PMCA O-METHYL-P-COUMARIC ACID O-METHYL-P-CUMARIC ACID OTAVA-BB BB0123400502 TRANS-3-(4-METHOXYPHENYL)ACRYLIC ACID METHOXYCINNAMIC ACID,4- AKOS B000181 AKOS BB/0034 AKOS BBS-00000769 LABOTEST-BB LT00108121 (E)-3-(4-METHOXYPHENYL)ACRYLIC ACID 3-(4-METHOXY-PHENYL)-ACRYLIC ACID (2E)-3-(4-METHOXYPHENYL)ACRYLIC ACID (E)-p-methoxycinnamic acid 2-Propenoic acid, 3-(4-methoxyphenyl)-, (2E)- 2-Propenoic acid, 3-(4-methoxyphenyl)-, (E)- (E)-4-MethoxycinnamicAci trans-O-Methyl-p-coumaric Acid (E)-3-(4-methoxyphenyl)prop-2-enoic acid 943-89-5 RARECHEM BK HC T257 (E)-3-(4-Methoxyphenyl)acrylic acid (compound 3) 943-89-5 786-13-1 Exciton Chirality CD Method (for Hydroxyl Groups) Absolute Conefiguration Determination (Exciton Chirality CD Method) Chalcones, etc. (Building Blocks for Liquid Crystals) Enantiomer Excess & Absolute Conefiguration Determination Building Blocks for Liquid Crystals Carboxylic Acids Carbonyl Compounds C10 Building Blocks Organic Building Blocks Benzenes 943-89-5