VERATRIDINE
- CAS No.
- 71-62-5
- Chemical Name:
- VERATRIDINE
- Synonyms
- NSC 7524;ybenzoate);Veratrdine;VERATRIDINE;,4alpha,16beta)-;Veratridine, >=98%;veratrine(amorphous);3-VERATROYLVERACEVINE;VERATRIDINE FREE BASE;Veracevine, veratrate
- CBNumber:
- CB1156432
- Molecular Formula:
- C36H51NO11
- Molecular Weight:
- 673.79
- MDL Number:
- MFCD16661233
- MOL File:
- 71-62-5.mol
- MSDS File:
- SDS
| Melting point | 180℃ |
|---|---|
| alpha | D20 +8.0° (ethanol) |
| Boiling point | 689.74°C (rough estimate) |
| Density | 1.45±0.1 g/cm3 (20 ºC 760 Torr) |
| refractive index | 1.6630 (estimate) |
| storage temp. | -20°C |
| solubility | ethanol: 50 mg/mL |
| form | powder |
| pka | 9.54(at 25℃) |
| color | white to off-white |
| Merck | 13,10016 |
| BRN | 78875 |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months. |
| EWG's Food Scores | 1 |
| FDA UNII | M4BNP1KR7W |
| EPA Substance Registry System | Veratridine (71-62-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H300+H310+H330-H315-H319-H335 |
| Precautionary statements | P260-P262-P280-P302+P352+P310-P304+P340+P310-P305+P351+P338 |
| Hazard Codes | T+ |
| Risk Statements | 26/27/28-36/37/38-62-52/53-48/20 |
| Safety Statements | 26-36/37/39-45-61-36/37-28 |
| RIDADR | UN 1544 6.1/PG 1 |
| WGK Germany | 2 |
| RTECS | YX5600000 |
| F | 10 |
| HazardClass | 6.1(a) |
| PackingGroup | II |
| Toxicity | LD50 in mice (mg/kg): 1.35 i.p. (Swiss, Bauer); 0.42 i.v. (Krayer); 6.3 s.c. (Tanaka) |
VERATRIDINE price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | V5754 | Veratridine ≥90% (HPLC), powder | 71-62-5 | 10mg | $241 | 2024-03-01 | Buy |
| Sigma-Aldrich | 676950-M | Veratridine - CAS 71-62-5 - Calbiochem A Na+ channel opener. | 71-62-5 | 5mg | $107 | 2024-03-01 | Buy |
| Sigma-Aldrich | 676950-M | Veratridine - CAS 71-62-5 - Calbiochem A Na+ channel opener. | 71-62-5 | 676950-5MG | $104 | 2023-06-20 | Buy |
| Alfa Aesar | J62324 | Veratridine, 97+% | 71-62-5 | 50mg | $0 | 2021-12-16 | Buy |
| Sigma-Aldrich | V5754 | Veratridine ≥90% (HPLC), powder | 71-62-5 | 25mg | $470 | 2024-03-01 | Buy |
VERATRIDINE Chemical Properties,Uses,Production
Description
This steroidal alkaloid from Veratrum viride was given this name by Bosetti. It is almost certainly identical with the amorphous veratrine isolated by Schmidt and Koppen, Merck, and Wright and Luff. The base is a colourless, amorphous powder which melts over a wide range. It has [α]22D + 8.0° (EtOH) and yields a sulphate nonahydrate which forms colourless silky needles that resinify in air. The nitrate is only sparingly soluble in H2O. The solution of the alkaloid in H2SO4 becomes orange-red and eventually crimson with a blue fluorescence while that in HCI is colourless. Alkaline hydrolysis furnishes veratric acid and cevine.
Uses
Veratridine causes Na+ channels to stay open during a sustained membrane depolarization by abolishing inactivation.?This, in turn, opens voltage-activated calcium channels, thus increasing intracellular calcium content and inducing neurotransmitter release. Alkaloid neurotoxin which depolarizes excitable tissue; used to increase membrane sodium permeability.
Definition
ChEBI: Veratridine is a steroid. It has a role as a sodium channel modulator. It is functionally related to a cevane.
General Description
Veratridine is one of several alkaloids isolated from the seeds of Schoenocaulon officinale and from the rhizome of Veratrum album. The crude extract is called veratrine or sabadilla and contains cevadine, veratridine, cevadilline, sabadine and cevine. It is a neurotoxin, which belongs to the family Liliaceae and genus, Schoenocaulon. Veratridine is soluble in lipid.
Biochem/physiol Actions
Opens voltage-dependent Na+ channels and prevents their inactivation. This, in turn, opens voltage-activated calcium channels, thus increasing intracellular calcium content and inducing neurotransmitter release. Alkaloid neurotoxin which depolarizes excitable tissue; used to increase membrane sodium permeability. Veratridine is cytotoxic to chromaffin cells in vitro.
storage
-20°C
Purification Methods
It is an alkaloid neurotoxin which prevents inactivation of Na+ channels. Its solubility in EtOH is ~5%; and it separates as a pale yellow powder from an ethanolic solution on addition of Et2O. It forms nitrate, sulfate and perchlorate salts. [McKinney et al. Anal Biochem 153 33 1986, Beilstein 21 V/13 709.]
References
Merck., Annalen, 95, 200 (1855)
Schmidt, Koppen., Ber., 9, 1115 (1876)
Wright, Luff.,J. Chem. Soc., 35, 421 (1879)
Bosetti., Arch. Pharm., 221,82 (1883)
Blount., Chem. Zeit., 26,334 (1902)
VERATRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12457 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5993 | 58 |
| hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 | sales03@chemcn.cn | China | 951 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 | info@konochemical.com | China | 2995 | 58 |
| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | sales@pioneerbiotech.com | China | 3000 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| BOC Sciences | +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503259 +86-19930503259 | cherry@crovellbio.com | China | 18457 | 58 |
View Lastest Price from VERATRIDINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-22 | VERATRIDINE
71-62-5
|
US $30.00 / kg | 1kg | 98% | 2000kg | hebei hongtan Biotechnology Co., Ltd | |
 |
2023-11-18 | VERATRIDINE
71-62-5
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | |
 |
2023-11-14 | VERATRIDINE
71-62-5
|
US $0.00 / kg | 1kg | 0.99 | 20 tons | Hebei Yanxi Chemical Co., Ltd. |
-
- VERATRIDINE
71-62-5
- US $30.00 / kg
- 98%
- hebei hongtan Biotechnology Co., Ltd
-
- VERATRIDINE
71-62-5
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
-
- VERATRIDINE
71-62-5
- US $0.00 / kg
- 0.99
- Hebei Yanxi Chemical Co., Ltd.