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Isosorbide

CAS No.
652-67-5
Chemical Name:
Isosorbide
Synonyms
(3R,3aR,6S,6aR)-Hexahydrofuro[3,2-b]furan-3,6-diol;at101;IsMotic;Isosorbide (75% solution, 1 g);ucitoL;isobide;hydronol;Isosorbid;NSC 40725;devicoran
CBNumber:
CB1162705
Molecular Formula:
C6H10O4
Molecular Weight:
146.14
MDL Number:
MFCD00064827
MOL File:
652-67-5.mol
MSDS File:
SDS
Last updated:2023-09-06 17:45:48

Isosorbide Properties

Melting point 60-63 °C (lit.)
Boiling point 175°C/2mmHg(lit.)
alpha 42 º (c=3, H2O)
Density 1.0945 (rough estimate)
vapor pressure 0.007Pa at 20℃
refractive index 45 ° (C=5, H2O)
storage temp. Inert atmosphere,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly), Water (Slightly)
pka 13.17±0.40(Predicted)
form Crystals, Crystalline Solid or Mass
color Off-white to light yellow or beige
optical activity [α]20/D +45.2°, c = 3 in H2O
Water Solubility Soluble in alcohols, water and ketones.
Sensitive Hygroscopic
Merck 14,5224
BRN 80510
InChIKey KLDXJTOLSGUMSJ-JGWLITMVSA-N
LogP -1.39 at 20℃
CAS DataBase Reference 652-67-5(CAS DataBase Reference)
FDA UNII WXR179L51S
EPA Substance Registry System D-Glucitol, 1,4:3,6-dianhydro- (652-67-5)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS05
Signal word  Warning
Hazard statements  H227
Precautionary statements  P501-P210-P280-P370+P378-P403+P235
Risk Statements  22
Safety Statements  24/25
WGK Germany  2
RTECS  LZ4380000
TSCA  Yes
HS Code  29349990
NFPA 704
1
0 0

Isosorbide price More Price(41)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 329207 Dianhydro-D-glucitol 98% 652-67-5 100g $91.5 2024-03-01 Buy
Sigma-Aldrich 1352008 Isosorbide United States Pharmacopeia (USP) Reference Standard 652-67-5 1g $436 2024-03-01 Buy
TCI Chemical I0407 Isosorbide >98.0%(GC) 652-67-5 25g $28 2024-03-01 Buy
TCI Chemical I0407 Isosorbide >98.0%(GC) 652-67-5 100g $54 2024-03-01 Buy
Alfa Aesar A13989 D-Isosorbide, 98% 652-67-5 50g $39.3 2024-03-01 Buy
Product number Packaging Price Buy
329207 100g $91.5 Buy
1352008 1g $436 Buy
I0407 25g $28 Buy
I0407 100g $54 Buy
A13989 50g $39.3 Buy

Isosorbide Chemical Properties,Uses,Production

Chemical Properties

off-white to light yellow or beige crystals,

Uses

pharmaceutical intermediate for dimethyl ether and mono- and dinitrate derivatives; the nitrate esters find use as vasodilators and coronary disease therapeutics.

Uses

D-Isosorbide is used as a reagent in the preparation of detergents, agrochemicals, cleansers, cosmetics and vasodilators. It is also employed as a pharmaceutical intermediate for dimethyl ether and mono- and dinitrate derivatives, which is used as vasodilators and coronary disease therapeutics. It is used in the treatment of hydrocephalus and glaucoma. It finds application as a building block for polymers like polycarbonates and polyesters.

Uses

Isosorbide is a reagent widely used to prepare detergents, cleansers, cosmetics, agrochemicals and vasodilators.

Definition

A polyol with a hydroxyl group attached to each of two cis-oriented saturated furan rings. Intermediate for pharmaceuticals. Combustible.

brand name

Ismotic (Alcon).

Biological Functions

emergency treatment of acute angle-closure glaucoma. It should not be confused with isosorbide dinitrate, an antianginal drug.

Flammability and Explosibility

Non flammable

Clinical Use

Isosorbide is basically a bicyclic form of sorbitol that is used orally to cause a reduction in intraocular pressure in glaucoma cases. Although a diuretic effect is noted, its ophthalmologic properties are its primary value.

50-70-4
652-67-5
Synthesis of Isosorbide from Sorbitol
Global( 432)Suppliers
Supplier Tel Email Country ProdList Advantage
Jinan Hongbaifeng Industry And Trade Co., Ltd
+86-531-87333789 +86-15066110813 hongbaifeng@live.cn China 2 58
Hebei Mojin Biotechnology Co., Ltd
+8613288715578 sales@hbmojin.com China 12452 58
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21700 55
Shanghai Time Chemicals CO., Ltd.
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+86-19930503282 alice@crovellbio.com China 8823 58
Xiamen AmoyChem Co., Ltd
+86-592-6051114 +8618959220845 sales@amoychem.com China 6387 58
Changzhou Ditong Chemical Co.,Ltd
+86-0519-88299272 info@edengenechem.com China 2169 58

View Lastest Price from Isosorbide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Isosorbide pictures 2023-09-06 Isosorbide
652-67-5
US $0.00 / KG 1KG 99% 50000KG/month Hebei Mojin Biotechnology Co., Ltd
Isosorbide pictures 2023-08-10 Isosorbide
652-67-5
US $7.00-4.80 / kg 25kg 98.5 300tons Jinan Hongbaifeng Industry And Trade Co., Ltd
Isosorbide pictures 2023-08-10 Isosorbide
652-67-5
US $7.50-7.00 / kg 25kg 98.5 300tons Jinan Hongbaifeng Industry And Trade Co., Ltd
  • Isosorbide pictures
  • Isosorbide
    652-67-5
  • US $0.00 / KG
  • 99%
  • Hebei Mojin Biotechnology Co., Ltd
  • Isosorbide pictures
  • Isosorbide
    652-67-5
  • US $7.00-4.80 / kg
  • 98.5
  • Jinan Hongbaifeng Industry And Trade Co., Ltd
  • Isosorbide pictures
  • Isosorbide
    652-67-5
  • US $7.50-7.00 / kg
  • 98.5
  • Jinan Hongbaifeng Industry And Trade Co., Ltd
Dianhydro-D-glucitol 98% 1,4:3,6-DIANHYDRO-D-SORBITOL 1,4:3,6-DIANHYDROGLUCITOL 1,4:3,6-DIANHYDROSORBITOL 1,4:3,6-DIANHYDRO-D-GLUCITOL D-ISOSORBIDE DIANHYDRO-D-GLUCITOL DIANHYDRO-D-SORBITOL ISOSORBIDE (3S,3AR,6R,6AR)-HEXAHYDRO-FURO[3,2-B]FURAN-3,6-DIOL 1,4:3,6-dianhydro-d-glucito Isosorbide, typically 98% 1,4:3,6-Dianhydro-D-sorbitol, D-Isosorbide Isosorbide,98% Dianhydro-D-glucitol,1,4:3,6-Dianhydro-D-sorbitol, D-Isosorbide Isosorbide, 98% 100GR 1,4:3,6-Dianhydroglucitol 1,4:3,6-Dianhydrosorbitol 1,4,3,6,5-Dianhydrosorbitol ISOSONBIDE(1,4:3,6-DIANHYDRO-D-SORHITOL) Isosorbid D-Glucitol, 1,4:3,6-dianhydro- D-Glucitol, 1,4:3,6-dianhydro- (9CI) NSC 40725 1,4,3,6-DIANHYDRO-D-GLUCITOL D-ISOSORBIDE 4:3,6-dianhydro-d-glucito d-1,4:3,6-dianhydroglucitol devicoran hydronol isobide Isosorbide,typically98% Isosorbide Isosorbide Isosorbide> Isosorbide, 97%, reagent grade Dianhydro-D-g ucitoL Dianhydro-D-gL Isosorbide USP/EP/BP Isosorbide Impurity 21 Isosorbide Impurity 22 IsosorbideQ: What is Isosorbide Q: What is the CAS Number of Isosorbide Q: What is the storage condition of Isosorbide Q: What are the applications of Isosorbide Isosorbide (75% solution, 1 g) (1352008) Isosorbide (75% solution, 1 g) IsMotic (3R,3aR,6S,6aR)-Hexahydrofuro[3,2-b]furan-3,6-diol at101 1,4:3,6-dianhydro-D-[UL-13C6]glucitol Isosorbitol (3S, 3AR, 6R, 6AR) - Hexahydrogen - [3,2-B] furan-3,6-diol) Isosorbide 1,4:3,6-Dianhydro-D-glucitol 652-67-5 662-67-5 Carbohydrate Synthesis Specialty Synthesis Monosaccharides Carbohydrates & Derivatives Heterocycles Intermediates & Fine Chemicals Pharmaceuticals