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Methyl nicotinate

CAS No.
93-60-7
Chemical Name:
Methyl nicotinate
Synonyms
NICOTINIC ACID METHYL ESTER;METHYL PYRIDINE-3-CARBOXYLATE;Nikomet;METHYL 3-PYRIDINECARBOXYLATE;Nicometh;FEMA 3709;Methyl nictinate;AKOS BBS-00004415;METHYL NICOTINATE;Methyl Nicotinatey
CBNumber:
CB1173538
Molecular Formula:
C7H7NO2
Molecular Weight:
137.14
MDL Number:
MFCD00006388
MOL File:
93-60-7.mol
MSDS File:
SDS
Last updated:2024-03-27 16:59:26

Methyl nicotinate Properties

Melting point 42-44 °C (lit.)
Boiling point 204 °C (lit.)
Density 1.2528 (rough estimate)
vapor pressure 0.4 hPa (25 °C)
refractive index 1.5323 (estimate)
FEMA 3709 | METHYL NICOTINATE
Flash point 204 °F
storage temp. Store below +30°C.
solubility H2O: 0.1 g/mL, clear
pka pKa 3.1 (Uncertain)
form Crystals or Crystalline Powder
color White to brownish
Odor at 10.00 % in dipropylene glycol. warm herbal tobacco
Odor Type herbal
Water Solubility NEGLIGIBLE
JECFA Number 1320
Merck 14,6100
BRN 113951
InChIKey YNBADRVTZLEFNH-UHFFFAOYSA-N
LogP 0.68 at 25℃
CAS DataBase Reference 93-60-7(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS) METHYL NICOTINATE
FDA 21 CFR 310.545
EWG's Food Scores 1
FDA UNII 7B1AVU9DJN
NIST Chemistry Reference Methyl nicotinate(93-60-7)
EPA Substance Registry System Methyl nicotinate (93-60-7)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38-36/38
Safety Statements  26-36-37/39
WGK Germany  3
RTECS  QT1925000
TSCA  Yes
HS Code  29333999
Toxicity LD50 orally in Rabbit: > 2000 mg/kg
NFPA 704
1
2 0

Methyl nicotinate price More Price(40)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich W370908 Methyl Nicotinate ≥99%, FG 93-60-7 5kg $678 2024-03-01 Buy
Sigma-Aldrich 8.18713 Methyl nicotinate for synthesis 93-60-7 100g $45.8 2024-03-01 Buy
Sigma-Aldrich 8.18713 Methyl nicotinate for synthesis 93-60-7 500g $159 2024-03-01 Buy
Sigma-Aldrich 72420 Methyl nicotinate puriss., ≥99.0% (GC) 93-60-7 100g $45.8 2024-03-01 Buy
Sigma-Aldrich 69193 Methyl nicotinate AldrichCPR 93-60-7 100mg $173 2022-05-15 Buy
Product number Packaging Price Buy
W370908 5kg $678 Buy
8.18713 100g $45.8 Buy
8.18713 500g $159 Buy
72420 100g $45.8 Buy
69193 100mg $173 Buy

Methyl nicotinate Chemical Properties,Uses,Production

Description

Methyl nicotinate is a skin irritant in man, in particular producing vasodilatation, which is used on purpose in “rubefacient”, to produce a redness or inflammation for a short period of time, often in lip plumper or other lip products. Methyl nicotinate is also an active ingredient of a number of veterinary preparations intended for topical application as a rubefacient for the treatment of a variety of diseases, such as respiratory diseases, vascular disorders (oedema, haematoma), and rheumatoid disorders in cattle and horses (doses not stated; the concentration in the formulated veterinary medicinal product is 2%).

Chemical Properties

Methyl nicotinate is white to brownish crystals or crystalline powder and has a fresh, caramellic, nutty and mild tobacco odor.

Occurrence

Reported found in ground coffee, roasted filberts, guanabana (Annona muicata L.), roasted peanuts, wild strawberries, vanilla bean, papaya, guava, plum, beer cognac, soursop, malt, wort, Bourbon vanilla and mountain papaya.

Uses

Methyl nicotinate (MN) is the methyl ester of nicotinic acid that is used as an active ingredient, a rubefacient and counter-irritant in over-the-counter topical preparations indicated for the temporary relief of aches and pains in muscles,tendons, and joints. The action of methyl nicotinate as a rubefacient is thought to involve peripheral vasodilation.For veterinary purposes,methyl nicotinate is used to treat respiratory diseases, vascular disorders, rheumatoid arthritis, and muscle and joint pains.Methyl nicotinate can be found in in guava fruit, papaya, strawberry, soursop(Annona muricata), beer, grape brandy, coffee, roasted filbert, roasted peanut and Bourbon vanilla.

Application

Methyl nicotinate can be employed as a precursor in the synthesis:
Di-3-pyridyl ketone ligand, which is used in the preparation of silver(I) complexes for the derivation of coordination polymeric chains.
5-arylnicotinates , ±-sesbanine , and 1,4-dihydropyridine derivatives.

Preparation

Methyl nicotinate was prepared by esterification of nicotinic acid by refluxing with methanol in the presence of concentrated sulphuric acid, esterification product obtained was extracted into organic solvent (chloroform) after neutralization of the reaction mixture with 10% sodium bicarbonate.
Synthesis and antinociceptive activity of methyl nicotinate
DOI:10.4314/jpb.v12i1.8

Definition

ChEBI: Methyl nicotinate is a member of pyridines and an aromatic carboxylic acid.

General Description

Methyl nicotinate (or nicotinic acid methyl ester) is used as a rubefacient for the relief of pains in muscles, tendons, and joints. It is also used in food as a flavoring agent.

Side effects

There is presently no side effect information available for Methyl nicotinate(MN) itself. a few patients who applied a medicated topical preparation containing MN (and other components) suffered adverse reactions including faintness, nausea, pain and skin rashes.

Safety

No data are available for chronic toxicity of Methyl nicotinate(MN) in humans. No adverse effects were reported for nicotinamide in clinical studies, whereas high doses of NA (3000 mg/day) are associated with considerable toxicity. In one third to one half of the 1119 patients taking 3000 mg NA /day for at least five years (to reduce the incidence of a second myocardial infarction), side effects included gastrointestinal and urinary tract problems, as well as dermatological problems of flushing, itching and rash ("The Coronary Drug Project", 1975, cited in "monograph of methyl nicotinate", Council of Europe, 2008, pp. 248).

Carcinogenicity

No data on the mutagenic or carcinogenic potential of methyl nicotinate were presented. However life-time studies in mice employing doses of 2 to 3 mg nicotinamide/kg bw/day gave no indication of carcinogenic potential.

Global( 522)Suppliers
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Hebei Guanlang Biotechnology Co,.LTD
+8619930503252 daisy@crovellbio.com China 5966 58
Anhui Zhongda Biotechnology Co., Ltd
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Henan Fengda Chemical Co., Ltd
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airuikechemical co., ltd.
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ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32480 60

View Lastest Price from Methyl nicotinate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Methyl nicotinate  pictures 2024-03-28 Methyl nicotinate
93-60-7
US $10.00 / kg 1kg 99.9% 500 hebei hongtan Biotechnology Co., Ltd
methyl nicotinate pictures 2024-03-27 methyl nicotinate
93-60-7
US $0.00-0.00 / Kg 1Kg 99.9% 200tons airuikechemical co., ltd.
Methyl nicotinate pictures 2024-01-18 Methyl nicotinate
93-60-7
US $6.00-0.60 / KG 1KG 99% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd
RARECHEM AL BF 0185 PYRIDINE-3-CARBOXYLIC ACID METHYL ESTER PELLAGRA PREVENTIVE FACTOR METHYL ESTER NICONACID METHYL ESTER NIACIN METHYL ESTER METHYL NICOTINATE DAC Methyl nictinate METHYL NICOTINATE 99+% METHYL NICOTINATE STANDARD FOR GC 3-Picolinic Acid Methyl Ester METHYLNICOTINATE,REAGENT 3-CARBOXYPYRIDINE METHYL ESTER 3-PYRIDINECARBOXYLIC ACID METHYL ESTER AKOS BBS-00004415 Nicotinic Acid Methyl Eater FEMA 3709 Methyl Nicotinate (Nicotinic Acid Methyl Ester) Methyl nicotinate puriss., >=99.0% (GC) Methyl pyridine-3-carboxylate Nicotinic acid methyl ester 3-(carbomethoxy)pyridine 3-(Methoxycarbonyl)pyridine 3-Carbomethoxypyridine m-(methoxycarbonyl)pyridine Methyl ester of pyridine-3-carboxylic acid methylnicotinicacid Nicometh METHYL NICOTINATE Methyl nicotinate CRS MethylNicotinate> METHYL NICOTINATE 500 G Methyl Nicotinatey Methyl nicotinate ISO 9001:2015 REACH METHYL PYRIDINE-3- Methyl nicotinate(MNCT) Methyl nicotinateinate METHYL NICOTINEATE METHYL NICOTINATE Extra Pure NICOTINIC ACID METHYL ESTER METHYL PYRIDINE-3-CARBOXYLATE METHYL 3-PYRIDINECARBOXYLATE Nikomet Mythyl Nicotinate Methyl nicotinate / Methyl 3-pyridinecarboxylate /Nicotinic 93-60-7 META - METH Pyridines Heterocyclic Building Blocks Building Blocks Analytical Standards Analytical Chromatography Product Catalog Alphabetic C7 and C8 Pharmaceutical Intermediates Heterocyclic Compounds bc0001 93-60-7