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Hyaluronic acid

Hyaluronic Acid Mechanisms of Action

CAS No. 9004-61-9
Chemical Name: Hyaluronic acid
Synonyms: Mucoitin;Sepracoat;Hyaluronic acid;Hydluronic acid;Hyalobarrier gel;Haluronic acid、HA;Chlamyhyaluronic acid;HYALURONIC ACID SODIUM;HYALURONIC ACID NA-SALT;HYALURONICACID(HA)38%(BULK
CBNumber: CB1176690
Molecular Formula: C14H22NNaO11
Formula Weight: 403.31
MOL File: 9004-61-9.mol
Hyaluronic acid Property
storage temp. : −20°C
solubility : H2O: 5 mg/mL, clear, colorless
form : Lyophilized Powder
color : White
Water Solubility : Soluble in water.
EPA Substance Registry System: Hyaluronic acid(9004-61-9)
Hazard Codes : B
Safety Statements : 22-24/25
WGK Germany : 3
RTECS : MT7250000
F : 3-10
TSCA : Yes
Hazardous Substances Data: 9004-61-9(Hazardous Substances Data)

Hyaluronic acid Chemical Properties,Usage,Production

Hyaluronic Acid
Hyaluronic acid is a completely transparent, non-adhesive, water-soluble and grease-free acid mucopolysaccharide. Its molecular weight is between a few hundred thousand to millions, and it makes up the dermis layer of the skin. Its unique molecular structure and physicochemical properties has many important physiological functions inside the body, such as lubricating joints, adjusting vascular permeability, adjusting proteins, diffusing and transporting water electrolytes, and promoting wound healing. Hyaluronic acid has a unique water retention effect and has the best known natural moisturizing properties, making it the ideal natural moisturizer.
Hyaluronic acid is an essential drug in ophthalmic “sticky surgeries”. It is used in cataract surgery, in which its sodium salt remains in the anterior chamber to maintain depth in the anterior chamber and ensure a clear surgical view. It reduces the occurences of postoperative inflammation and complications, thus improving the vision-correcting effects of the surgery. It is also used in complicated retinol detachment surgery. Hyaluronic acid has a low molecular weight and is considered the ideal natural moisturizing agent, so it is used as an additive in high-end makeup and as a moisturizer in creams, gels, lotions, masks, and serums. It is also used medically as a moisturizer to improve moisture retention and lubrication, and it also expands capillaries and improves skin health. For example, hyaluronic acid with a low molecular weight can be used as a lubricant in surgeries (such as knee surgery), while those with high molecular weight can be used as surgical lubricant and as a substitute for vitreous in ophthalmic surgery.
Mechanisms of Action
Hyaluronic acid’s main functions include:
  • Has excellent affinity to water and can regroup water within tissue for better retention and lubrication.
  • Folds to form a three-dimensional network and produces physiological effects, including producing fluid resistance, maintaining water balance and bodily stability, influencing macromolecule solubility, structure, chemical balance and system osmotic pressure, preventing the spread of pathogens, and promote the condensation of collagen fiber secretory substances.
  • Forms polymers with inseparable proteins to maintain tissue shape and size and to ensure reversible tissue compression resistance.
  • Affects macrophages, adherent cells, lymph cells, and natural killer cells.
  • Serves as an important part of interstitial fluid and is mainly metabolized in the liver. Liver fiber activity increases HA synthesis; combined with reduced function during cirrhosis, blood HA levels may increase abnormally.
ChEBI: A mucopolysaccharide composed of N-acetylglucosamine and glucuronic acid subunits. It is found in the connective tissues of vertebrates.
Hyaluronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
Hyaluronic acid Suppliers      Global( 228)Suppliers     
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD. +86-371-55541817 CHINA 2887 58
Wuhan Landed Scientific Ltd. 027-88739577 18163556322
027-88739578 China 61 55
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933; China 96831 76
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing) China 40403 62
INTATRADE GmbH +49 3493/605464
+49 3493/605470 Germany 3589 66
future industrial shanghai co., ltd 021-61552785,400-0066-400
021-55660885 China 2091 65
Arden pharmaceutical &chemical Co., Ltd +86-(0)533-3595900 13793319233
+86-(0)533-3595900 China 670 61
TCI (Shanghai) Development Co., Ltd. 800-988-0390
021-67121385 China 22833 81
Energy Chemical 021-58432009 / 400-005-6266
021-58436166-800 China 44197 61
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078,021-50426030
86-021-50426522,50426273 China 10094 60
9004-61-9(Hyaluronic acid)Related Search:
Cupric acetylacetonate COBALT ETHYLENE DIAMINE CHLORIDE Tosylmethyl isocyanide SALCOMINE PHENYLSELENOL BENZYL ISOCYANIDE Chondroitin 6-sulfate sodium salt Ferric acetylacetonate DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) 2,4-PENTANEDIONE, SILVER DERIVATIVE CHROMIUM(III) ACETYLACETONATE Hyaluronic acid Hyaluronidase Folic acid phosphoric acid ACETIC ACID Glycine Citric acid
9004-61-9 Cell Signaling and Neuroscience Cell Biology Carbohydrate BioChemical Activity Other Activity [BETA-SODIUM-GLUCONATE-(1,3)-BETA-N-ACETYL-D-GLUCOSAMINE-1,4-]N COPOLY(BETA-GLUCURONIC ACID-[1->3]-BETA-N-ACETYLGLUCOSAMINE-[1->4] SODIUM SALT HYALURONIC ACID NA-SALT HYALURONIC ACID, SODIUM SALT, STREPTOCOCCUS SPECIES HYALURONIC ACID SODIUM HYALURONIC ACID HUMAN SODIUM SALT Cytoskeleton and Extracellular Matrix Extracellular Matrix Extracellular Matrix Peptides and Proteins Metabolomics Metabolites and Cofactors on the Metabolic Pathways Chart Metabolic Pathways POLY(BETA-GLUCURONIC ACID-[1->3]-BETA-N-ACETYLGLUCOSAMINE-[1->4]), ALTERNATING SODIUM HYALURONATE (STREPTOCOCCUS) hyaluronic acid from bovine vitreous humor Hyaluronic acid from Cockscomb hyaluronic acid sodium from*streptococcus zooepid Hyaluronic Acid Food /Cosmetic Grade /Injection 90.0% Min. C14H22NO11Na C14H21NO11n HYALURONICACID(HA)38%(BULK disodium 3-[3-acetamido-4-(6-carboxylato-3,4,5-trihydroxy-oxan-2-yl)oxy-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-[3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-4,5-dihydroxy-oxane-2-carboxylate C16H27NO12 Haluronic acid、HA HYALURONIC ACID - FOOD GRADE HYALURONIC ACID - INJECTABLE GRADE HYALURONIC ACID - PHARMA GRADE HYALURONIC ACID FOOD GRADE (VIA EXTRACTION) HYALURONIC ACID INJECTION GRADE Substrates Hyaluronic acid C14H22NO11種a HYALURONIC ACID (SODIUM HYALURONATE) Cnbio Hydluronic acid Chlamyhyaluronic acid Hyalobarrier gel Mucoitin Sepracoat Hyaluronic Acid from Bovine Vitreous Humor [Substrate for Hyaluronidase] Hyaluronic Acid, from Human Umbilical Cords sodiuM (2S,3S,4R,5R,6R)-3-((2S,3R,5S,6R)-3-acetaMido-5-hydroxy-6-(hydroxyMethyl)tetrahydro-2H-pyran-2-yloxy)-4,5,6-trihydroxytetrahydro-2H-pyran-2-carboxylate hyaluronic acid/hyaluronic acid sodium Hyaluronic acid, bovine vitreous humor C14H21NO12n
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