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L-Glutathione

L-Glutathione Structure
L-Glutathione structure
CAS No.
27025-41-8
Chemical Name:
L-Glutathione
Synonyms
GSSG;L-GLUTATHIONE OXIDIZED;GLUTATHIONE DISULFIDE;Oxiglutatione;oxidizedglutathione;L-GLUTATHIONE OXIDISED;GSSC;NOV-002;Glutathiol;oxigluthione
CBNumber:
CB1200803
Molecular Formula:
C20H32N6O12S2
Molecular Weight:
612.63
MDL Number:
MFCD00063106
MOL File:
27025-41-8.mol
MSDS File:
SDS
Last updated:2024-04-12 23:00:59
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L-Glutathione Properties

Melting point 178 °C (dec.)(lit.)
alpha -99 º (c=4, water)
Density 1.3688 (rough estimate)
refractive index -105 ° (C=2, H2O)
storage temp. 2-8°C
solubility H2O: soluble
form powder
pka 2.12, 3.59, 8.75, 9.65(at 25℃)
color White to off-white
Water Solubility soluble
Merck 13,4488
BRN 1718700
Stability Stable. Incompatible with strong oxidizing agents.
InChIKey YPZRWBKMTBYPTK-USZNOCQGSA-N
CAS DataBase Reference 27025-41-8(CAS DataBase Reference)
FDA UNII ULW86O013H
EPA Substance Registry System Oxiglutatione (27025-41-8)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H335-H315-H319
Precautionary statements  P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-24/25-36/37/39-27-37/39
WGK Germany  2
RTECS  MC0556500
HS Code  29309090
Toxicity mouse,LD50,intravenous,> 2gm/kg (2000mg/kg),Kiso to Rinsho. Clinical Report. Vol. 23, Pg. 6793, 1989.
NFPA 704
0
2 0

L-Glutathione price More Price(65)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich G2299 L-Glutathione oxidized PharmaGrade, Manufactured under appropriate controls for use as a raw material in pharma or biopharmaceutical production. 27025-41-8 100g $1586 2024-03-01 Buy
Sigma-Aldrich G2299 L-Glutathione oxidized PharmaGrade, Manufactured under appropriate controls for use as a raw material in pharma or biopharmaceutical production. 27025-41-8 1kg $10456 2024-03-01 Buy
Sigma-Aldrich 3542 Glutathione, Oxidized, Free Acid - CAS 27025-41-8 - Calbiochem Glutathione,Oxidized,FreeAcid,CAS27025-41-8,formsa"redoxbuffer"inphys 27025-41-8 1g $96.7 2024-03-01 Buy
Sigma-Aldrich 3542 Glutathione, Oxidized, Free Acid - CAS 27025-41-8 - Calbiochem Glutathione,Oxidized,FreeAcid,CAS27025-41-8,formsa"redoxbuffer"inphys 27025-41-8 5G $265 2024-03-01 Buy
TCI Chemical G0073 Glutathione oxidized form >98.0%(HPLC) 27025-41-8 1g $64 2024-03-01 Buy
Product number Packaging Price Buy
G2299 100g $1586 Buy
G2299 1kg $10456 Buy
3542 1g $96.7 Buy
3542 5G $265 Buy
G0073 1g $64 Buy

L-Glutathione Chemical Properties,Uses,Production

Description

L-Glutathione oxidized(GSSG) is produced by the oxidation of glutathione. Detoxification of reactive oxygen species is accompanied by production of it. It can be used for the research of sickle cells and erythrocytes. The ratio of glutathione (GSH) to oxidised glutathione (GSSG) is a key indicator of cellular oxidative stress. It can be used in the clinical diagnosis and treatment of leukaemia by detecting the level of cellular GSH/GSSG in acute myeloid leukaemia (AML), which is characterised by oxidative stress leading to abnormally low levels of oxidised glutathione, with real-time, dynamic and highly sensitive characteristics[1].

Chemical Properties

White lyophilized powder

Uses

L-Glutathione is used as a Acts as hydrogen acceptor in enzymatic determination of NADP and NADPH, it is used to reduced back to glutathione (GSH) via the NADPH-dependent enzyme glutathione reductase. The ratio of GSH to GSSG is often used to gauge the level of oxidative stress in cells, with higher concentrations of GSSG implying more oxidative stress

Uses

S,S'-Ethylenebis(glutathione) is a haloethane-glutathione conjugate formed via GSH transferases. S,S'-Ethylenebis(glutathione) formation is used to study the polymorphism in glutathione conjugation ac tivity of human erythrocytes towards ethylene dibromide.

Uses

L(-)-Glutathione is a biomarker for fatty liver disease.

Application

L-Glutathione (GSH) has been used in the elution buffer to elute GST (glutathione S-transferase)-fused proteins using glutathione-agarose beads. It has been used to prepare a standard curve for GSH analyses. May be used at 5-10 mM to elute glutathione S-transferase (GST) from glutathione agarose.

Definition

ChEBI: Glutathione disulfide is an organic disulfide and a glutathione derivative. It has a role as an Escherichia coli metabolite and a mouse metabolite. It is a conjugate acid of a glutathione disulfide(2-).

Biochem/physiol Actions

L-Glutathione, oxidized is frequently measure in vivo as an indicator of oxidative stress. Oxidized L-Glutathione may be converted to L-glutathione by various reducing systems.

Side effects

There have been few studies on the side effects of glutathione use, and as a supplement, no associated side effects have been reported from consuming high glutathione only from diet. However, long-term use of glutathione supplements may reduce zinc levels, and inhaling glutathione can cause breathing problems in some people with mild asthma. In addition, there are concerns that the use of glutathione supplements may cause cramps and bloating or allergic reactions, accompanied by symptoms such as rashes. If you experience any of these side effects, stop taking the supplement and contact your doctor.

Purification Methods

Purify it by recrystallisation from 50% aqueous EtOH. Its solubility in H2O is 5%. Store it at 4o. [Li et al. J Am Chem Soc 76 225 1954, Berse et al. Can J Chem 37 1733 1959, Beilstein 4 IV 3168.]

References

[1] ABBASGHULAM. Construction of Genetically Encoded Biosensors to Monitor Subcellular Compartment-Specific Glutathione Response to Chemotherapeutic Drugs in Acute Myeloid Leukemia Cells.[J]. Analytical Chemistry, 2023, 95 5: 2838-2847. DOI:10.1021/acs.analchem.2c04255.

L-Glutathione synthesis

57564-91-7
27025-41-8
10102-43-9
Synthesis of L-Glutathione from S-NITROSOGLUTATHIONE

L-Glutathione Preparation Products And Raw materials

Raw materials

Preparation Products

GLUTATHIONESULFONIC ACID norophthalamic acid

L-Glutathione Suppliers

Global( 487)Suppliers
Supplier Tel Email Country ProdList Advantage
Maintain Biotech Co., Ltd.
+86-75589664337 +86-15112661142 cami@maintain-bio.com China 47 58
Hantai Biomedical Group Co. LTD
+8618819265912 id002@cnhantide.com China 37 58
Hebei Lingding Biotechnology Co., Ltd.
+86-18031140164 +86-19933155420 erin@hbldbiotech.com China 879 58
Shanghai Chinqesen Biotechnology Co., Ltd. 		+86-16628886292 +86-19521323435 sales2@qschem-pharma.com China 46 58
Hebei Mojin Biotechnology Co., Ltd 		+8613288715578 sales@hbmojin.com China 12453 58
Shanghai UCHEM Inc. 		+862156762820 +86-13564624040 sales@myuchem.com China 6711 58
XI'AN TIANGUANGYUAN BIOTECH CO., LTD. 		+86-029-86333380 18829239519 sales06@tgybio.com China 961 58
henan kanbei chemical co.,ltd 		+undefined-86-1523780-4566 +undefined15237804566 henankanbeichemical@163.com China 511 58
Henan Tengmao Chemical Technology Co. LTD 		+8615238638457 salesvip2@hntmhg.com China 415 58
Xiamen Wonderful Bio Technology Co., Ltd. 		+8613043004613 Sara@xmwonderfulbio.com China 305 58
Supplier Advantage
Maintain Biotech Co., Ltd.
58
Hantai Biomedical Group Co. LTD
58
Hebei Lingding Biotechnology Co., Ltd.
58
Shanghai Chinqesen Biotechnology Co., Ltd. 		58
Hebei Mojin Biotechnology Co., Ltd 		58
Shanghai UCHEM Inc. 		58
XI'AN TIANGUANGYUAN BIOTECH CO., LTD. 		58
henan kanbei chemical co.,ltd 		58
Henan Tengmao Chemical Technology Co. LTD 		58
Xiamen Wonderful Bio Technology Co., Ltd. 		58

View Lastest Price from L-Glutathione manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
L-Glutathione pictures 2024-04-12 L-Glutathione
27025-41-8
 US $0.00-0.00 / KG 1KG 99 10 tons Shanghai Affida new material science and technology center
Glutathione Oxidized / GSSG pictures 2024-04-11 Glutathione Oxidized / GSSG
27025-41-8
 US $0.00 / kg 1kg 99.8% 1000 kg BINBO BIOLOGICAL CO.,LTD
L(-)-Glutathione pictures 2024-04-09 L(-)-Glutathione
27025-41-8
 US $0.00 / G 1G 98% HPLC 1000KG Changsha Staherb Natural Ingredients Co., Ltd.
  • L-Glutathione pictures
  • L-Glutathione
    27025-41-8
  • US $0.00-0.00 / KG
  • 99
  • Shanghai Affida new material science and technology center
  • L(-)-Glutathione pictures
  • L(-)-Glutathione
    27025-41-8
  • US $0.00 / G
  • 98% HPLC
  • Changsha Staherb Natural Ingredients Co., Ltd.

L-Glutathione Spectrum

L(-)-Glutathione(27025-41-8)1HNMRL(-)-Glutathione(27025-41-8)IR1L(-)-Glutathione(27025-41-8)Raman

27025-41-8(L-Glutathione)Related Search:

REDUCED GLUTATHIONE,L-GLUTATHIONE REDUCED,L-GLUTATHIONE (REDUCED FORM) Thiamine disulfide GLUTATHIONE PEROXIDASE S-LACTOYL-GLUTATHIONE METHYLGLYOXAL-LYASE [ISOMERIZING] NAD[P]H: OXIDIZED-GLUTATHIONE OXIDOREDUCTASE TYPE II,NAD[P]H: OXIDIZED-GLUTATHIONE OXIDOREDUCTASE,NAD[P]H: OXIDIZED-GLUTATHIONE OXIDOREDUCTASE TYPE VI
L-GLUTATHIONE OXIDIZED,L-GLUTATHIONE (OXIDIZED FORM),L-GLUTATHIONE OXIDISED,GSSG L-GLUTATHIONE OXIDIZED DISODIUM SALT,GSSG DISODIUM SALT,GSSG , OXIDIZED FORM DISODIUM SALT S-NITROSO-L-GLUTATHIONE RX: GLUTATHIONE R-TRANSFERASE S-(LACTOYL)GLUTATHIONE
N,S-BIS-FMOC-GLUTATHIONE L-Glutathione L-CYSTEINE-GLUTATHIONE DISULFIDE,L-CYSTEINE-GLUTATHIONE DISULPHIDE GGKPDLRPCHPPCHYIPRPKPR ([15N]GLY)-GLUTATHIONE (REDUCED)
S-(1-PENTYL-5-BIOTINYLAMIDO)GLUTATHIONE S-(N,N-DIETHYLCARBAMOYL)GLUTATHIONE S-LINKED GLUTATHIONE AGAROSE,GLUTATHIONE-UNIFLOW RESIN,GLUTATHIONE-SUPERFLOW RESIN

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GAMMA-L-GLUTAMYL-L-CYSTEINYLGLYCINE OXIDIZED (-)-GLUTATHIONE, OXIDIZED GLUTATHIONE, OXIDIZED FORM CYCLIC(GAMMA-GLU-CYS-GLY) CYCLIC(GAMMA-GLU-CYS-GLY)2 bi(glutathion-S-yl) GLUTATHIONE OXIDIZED FORM FREE ACID*LYOP HILIZED POW ** APPROVAL REQ **GLUTATHIONE OXIDIZED GLUTATHIONE OXIDIZED FORM FREE ACID*GRAD E II GLUTATHIONE OXIDIZED FORM FREE ACID*SIGM AULTRA L(-)-Glutathione, oxidized, hydrate, 95% Glycine, L-.gamma.-glutamyl-L-cysteinyl-, bimol. (2?2)-disulfide 2-amino-4-[[2-[2-[(4-amino-4-carboxy-butanoyl)amino]-2-(carboxymethylcarbamoyl)ethyl]disulfanyl-1-(carboxymethylcarbamoyl)ethyl]carbamoyl]butanoic acid Glutamine, N,N'-[dithiobis[1-[(carboxymethyl)carbamoyl]ethylene]]di- (7CI) Glutamine, N,N'-[dithiobis[1-[(carboxymethyl)carbamoyl]ethylene]]di-, L- (8CI) Glutathione-S-S-glutathione Glycine, L-g-glutamyl-L-cysteinyl-, bimol. (22')-disulfide (9CI) Oxidized L-glutathione Sleep-promoting factor B NOV-002 White lyophilizate L-Glutathione oxidized Vetec(TM) reagent grade, >=98% Glutathione(Oxidized Form), free acid n-(n-gamma-glutamyl-cysteinyl)glycine-(2,2)-disulfide N,N’-[dithiobis[1-[(carboxymethyl)carbamoyl]ethylene]]di-,L-Glutamine n’-(dithiobis(1-((carboxymethyl)carbamoyl)ethylene))di-l-glutamin oxigluthione S,S’-Ethylenebis(glutathione) L-.GLUTATHIONE (OXIDIZED) [N-(N-L-G-GLUTAMYL-L-CYSTEINYL)GLYCINE] GLUTATHIONE OXIDISED extrapure glutathione, oxidised Glutathiol, GSSG L-Glutathione oxidized, Glutathiol, GSSG 3,3'-Dithiobis[N-(carboxymethyl)-N2-(γ-glutamyl)alaninamide] N,N'-Bis(carboxymethyl)-Nα,Nα'-bis(γ-glutamyl)-L-cystinamide Oxyglutatione l-gamma-glutamyl-l-cysteinyl glycine L(-)-Glutathione, oxidized, hydrate,98+% L(-)-Glutathione, oxidized, hydrate,95% L(-)-Glutathione, oxidized,98% L-Glutathione oxidized,GSSG, Glutathiol ()-Glutathione, oxidized,L-Glutathione oxidized, GSSG, Glutathiol Glutathione Oxydized L(-)-Glutathionehydrate L(-)-Glutathione L(-)-Glutathione, oxidized, 98% 500MG N,N'-[Dithiobis[1-[(carboxyMethyl)carbaMoyl]ethylene]]diglutaMine GLT1JP-IN (L-GLUTATHIONE RED Glutathione IMpurity C (Disulfide IMpurity) glutathionedisulphide glutathione-ssg glutathonedisulfide Glycine,L-.gamma.-glutamyl-L-cysteinyl-,2,2’-disulfide glycine,l-gamma-glutamyl-l-cysteinyl-,(2,2’)-disulfide l-oxidizedglutathione N-(N-.gamma.-Glutamyl-cysteinyl)glycine-2,2-disulfide Glutathiol L-GLUTATHIONE (OXIDIZED FORM)