Ethisterone
- CAS No.
- 434-03-7
- Chemical Name:
- Ethisterone
- Synonyms
- Progestoral;17A-ETHYNYLTESTOSTERONE;Prone;Pranone;Pregnin;Gestoral;NSC-9565;Prodoxan;Produxan;Prolutol
- CBNumber:
- CB1207877
- Molecular Formula:
- C21H28O2
- Molecular Weight:
- 312.45
- MDL Number:
- MFCD00003656
- MOL File:
- 434-03-7.mol
| Melting point | 263-269 °C (lit.) |
|---|---|
| alpha | D23 +23.8° (dioxane); D25 -32.0° (pyridine) |
| Boiling point | 392.36°C (rough estimate) |
| Density | 1.0697 (rough estimate) |
| refractive index | 33 ° (C=1, Pyridine) |
| storage temp. | room temp |
| solubility | Soluble to 0.05 mg/mL (0.16 mM) in DMSO |
| pka | 13.10±0.60(Predicted) |
| Water Solubility | soluble in chloroform, DMSO (0.05 mg/ml), acetone (slightly ), ethanol (<1 mg/ml at 25°C), and water (<1 mg/ml at 25°C). |
| Merck | 14,3741 |
| BRN | 1889895 |
| InChIKey | CHNXZKVNWQUJIB-CEGNMAFCSA-N |
| CAS DataBase Reference | 434-03-7 |
| FDA UNII | P201BVY1MJ |
| ATC code | G03DC04 |
| NIST Chemistry Reference | Ethisterone(434-03-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS09 |
|---|---|
| Signal word | Danger |
| Hazard statements | H360FD-H410 |
| Precautionary statements | P201-P202-P273-P280-P308+P313-P391 |
| Hazard Codes | Xn,T |
| Risk Statements | 40-48-61 |
| Safety Statements | 22-24/25-45-53 |
| RIDADR | UN 2811 |
| WGK Germany | 3 |
| RTECS | TU5570250 |
| HS Code | 29372390 |
Ethisterone price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | E1001 | Ethisterone ≥99% (HPLC) | 434-03-7 | 25g | $252 | 2024-03-01 | Buy |
| Alfa Aesar | J63580 | Ethisterone, 98% | 434-03-7 | 5g | $176 | 2024-03-01 | Buy |
| Alfa Aesar | J63580 | Ethisterone, 98% | 434-03-7 | 25g | $382 | 2024-03-01 | Buy |
| Cayman Chemical | 22893 | Ethisterone ≥95% | 434-03-7 | 1g | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 22893 | Ethisterone ≥95% | 434-03-7 | 5g | $93 | 2024-03-01 | Buy |
Ethisterone Chemical Properties,Uses,Production
Description
Ethisterone is an orally bioavailable synthetic progestin and a derivative of testosterone (Item Nos. ISO60154 | 15645) that binds to progesterone and androgen receptors (EC50s = 23 and 23.1 nM, respectively, in yeast). Ethisterone (1 μM) downregulates progesterone receptors in MCF-7 cells.
Chemical Properties
Off-White Powder
Originator
Lutocyclin,Ciba
Uses
Synthetic progestogen; metabolite of Danazol; intermediate in the synthesis of Spironolactone
Uses
Ethisterone has been used as a component in Dulbecco′s modified eagle medium (DMEM) to culture the transfected COS-7 cell for transient transfection assay and?gene transfection assay.
Definition
ChEBI: A 17beta-hydroxy steroid that is testosterone in which the 17beta hydrogen is replaced by an ethynyl group. Ethisterone was the first orally active progestin and is a metabolite of danazol.
Manufacturing Process
0.5 part of δ5:6-17-ethinyl-androstendiol-(3:17) is dissolved in 10 parts of dry acetone, the solution is mixed with a solution of 1 part of tertiary aluminum butylate in 40 parts of absolute toluene and the whole is heated to boiling in a reflux apparatus for 21 hours. After the reaction mixture has cooled it is diluted with 100 parts of ether, the solution is washed with dilute mineral acid and with water, dried and the solvent is evaporated. In this manner there is obtained δ5:6-17-ethinyl-androstene-3-one-17-ol (ethisterone); MP: 270°- 272°C; it may be recrystallized from ethyl acetate.
Therapeutic Function
Progestin
General Description
Ethisterone is a?progestogen. It is a danazol derivative.
Biochem/physiol Actions
Ethisterone acts as a progestational agent. It is consumed by pregnant mothers to prevent miscarriage.
Ethisterone Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12453 | 58 |
| Wuhan Haorong Biotechnology Co.,ltd | +8618565342920 | sales@chembj.net | China | 269 | 58 |
| Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 | admin@guyunchem.com | China | 616 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 | alice@crovellbio.com | China | 8822 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
View Lastest Price from Ethisterone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-17 | Ethisterone
434-03-7
|
US $1.10 / g | 1g | 99.0% min | 100 tons min | Shaanxi Dideu Medichem Co. Ltd | |
 |
2024-04-01 | Ethisterone
434-03-7
|
US $0.00-0.00 / KG | 1KG | 99% | 500 | Wuhan Haorong Biotechnology Co.,Ltd | |
 |
2024-03-16 | Ethisterone
434-03-7
|
US $0.00 / KG | 100g | 98%+ | 100kg | WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD |
-
- Ethisterone
434-03-7
- US $1.10 / g
- 99.0% min
- Shaanxi Dideu Medichem Co. Ltd
-
- Ethisterone
434-03-7
- US $0.00-0.00 / KG
- 99%
- Wuhan Haorong Biotechnology Co.,Ltd
-
- Ethisterone
434-03-7
- US $0.00 / KG
- 98%+
- WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
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