LY 294002 HYDROCHLORIDE
- CAS No.
- 154447-36-6
- Chemical Name:
- LY 294002 HYDROCHLORIDE
- Synonyms
- YX;SF 1101;CS-1859;LY240092;LY 294002;NSC 697286;LY294002HCl;LY294002/PI3K;LY 294002, 99+%;PI3K inhibitor kit
- CBNumber:
- CB1242450
- Molecular Formula:
- C19H17NO3
- Molecular Weight:
- 307.34
- MDL Number:
- MFCD01530034
- MOL File:
- 154447-36-6.mol
- MSDS File:
- SDS
Melting point | 183-185℃ |
---|---|
Boiling point | 494.6±45.0 °C(Predicted) |
Density | 1.266 |
storage temp. | Sealed in dry,Store in freezer, under -20°C |
solubility | DMSO: >5 mg/mL |
form | solid |
pka | 0.55±0.20(Predicted) |
color | white to off-white |
Water Solubility | Soluble in DMSO at 5mg/ml. Insoluble in water |
Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 4 months. |
InChIKey | CZQHHVNHHHRRDU-UHFFFAOYSA-N |
CAS DataBase Reference | 154447-36-6 |
FDA UNII | 31M2U1DVID |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07,GHS08 |
---|---|
Signal word | Danger |
Hazard statements | H302-H320-H361-H370-H372-H336-H402 |
Precautionary statements | P501-P273-P260-P270-P202-P201-P271-P264-P280-P337+P313-P305+P351+P338-P308+P311-P301+P312+P330-P304+P340+P312-P403+P233-P405 |
Safety Statements | 24-25 |
WGK Germany | 3 |
HS Code | 29349990 |
LY 294002 HYDROCHLORIDE price More Price(75)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 440202 | LY 294002 | 154447-36-6 | 5mg | $216 | 2024-03-01 | Buy |
Sigma-Aldrich | 440202 | LY 294002 | 154447-36-6 | 10mg | $303 | 2024-03-01 | Buy |
TCI Chemical | M2410 | 2-Morpholino-8-phenylchromone >98.0%(HPLC) | 154447-36-6 | 25mg | $243 | 2024-03-01 | Buy |
Alfa Aesar | J67289 | LY 294002, 98% | 154447-36-6 | 5mg | $89.7 | 2023-06-20 | Buy |
Alfa Aesar | J67289 | LY 294002, 98% | 154447-36-6 | 10mg | $117 | 2021-12-16 | Buy |
LY 294002 HYDROCHLORIDE Chemical Properties,Uses,Production
Description
LY294002 is a selective phosphatidylinositol 3-
Uses
LY 294002 Hydrochloride is a highly selective inhibitor of Phosphatidylinositol 3-kinase (PI3K). It is a salt analogue of LY 294002 (L486590).
Uses
LY 294002 is a Phosphatidylinositol 3-kinase (PI3K) inhibitor which has shown to block the formation of tumor tissues in bone marrow cavity an abolish multiple myeloma (MM) induced osteoclast formation and osteolysis in SCID mice.
Uses
LY294002 is a selective phosphatidylinositol 3-kinase (PI3K) inhibitor with a 2.7-fold greater potency than quercetin. LY294002 inhibits purified PI3K with an IC50 of 1.4 μM.
Uses
A potent blocker of PI 3-kinase/Akt signaling.
Definition
ChEBI: A chromone substituted with a phenyl group at position 8 and a morpholine group at position 2.
Biological Activity
A highly selective inhibitor of phosphatidylinositol 3-kinase (IC 50 values are 0.31, 0.73, 1.06 and 6.60 μ M for PI3K β , PI3K α , PI3K δ and PI3K γ respectively). Inhibits proliferation and induces apoptosis in human colon cancer cells in vitro and in vivo .
target
p110α
References
1) Vlahos et al. (1994) A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY 294002); J. Biol. Chem., 269 5241
LY 294002 HYDROCHLORIDE Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49392 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
View Lastest Price from LY 294002 HYDROCHLORIDE manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2019-07-06 | LY 294002 HYDROCHLORIDE
154447-36-6
|
US $2.00 / kg | 1kg | 99% | 100kg | Career Henan Chemical Co |
- LY 294002 HYDROCHLORIDE
154447-36-6
- US $2.00 / kg
- 99%
- Career Henan Chemical Co
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