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Nicardipine hydrochloride

Nicardipine hydrochloride Structure
Nicardipine hydrochloride structure
CAS No.
54527-84-3
Chemical Name:
Nicardipine hydrochloride
Synonyms
YC-93;dafil;dagan;loxen;lincil;Vasonas;Dacarel;Barizin;Aprovan;NICODEL
CBNumber:
CB1244267
Molecular Formula:
C26H30ClN3O6
Molecular Weight:
515.99
MDL Number:
MFCD00057327
MOL File:
54527-84-3.mol
Last updated:2024-04-09 22:15:29
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Nicardipine hydrochloride Properties

Melting point 176-1780C
storage temp. 2-8°C
solubility DMSO: ~1 mg/mL
form powder
color yellow
Merck 14,6495
Stability Stable for 1 year from date of purchase as supplied. Solutions in distilled water or ethanol may be stored at -20°C for up to 1 month.
InChIKey AIKVCUNQWYTVTO-UHFFFAOYSA-N
CAS DataBase Reference 54527-84-3(CAS DataBase Reference)
FDA UNII K5BC5011K3

Pharmacokinetic data

Protein binding >99%
Excreted unchanged in urine <1%
Volume of distribution 0.8(L/kg)
Biological half-life 8.6 / Unchanged

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301+H311+H331
Precautionary statements  P280-P301+P310+P330-P302+P352+P312-P304+P340+P311
Hazard Codes  T
Risk Statements  23/24/25
Safety Statements  36/37/39-45
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  US7972100
HazardClass  6.1(b)
PackingGroup  III
HS Code  2933399090
Toxicity LD50 in male, female rats (mg/kg): 634, 557 orally; 18.1, 25.0 i.v.; in male, female mice: 634, 650 orally; 20.7, 19.9 i.v. (Odani, Sado)
NFPA 704
0
4 0

Nicardipine hydrochloride price More Price(32)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich N7510 Nicardipine hydrochloride powder, ≥98% 54527-84-3 1g $132 2024-03-01 Buy
Sigma-Aldrich PHR2531 Nicardipine hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material 54527-84-3 500MG $267 2024-03-01 Buy
Sigma-Aldrich 1463224 Nicardipine hydrochloride United States Pharmacopeia (USP) Reference Standard 54527-84-3 200mg $436 2024-03-01 Buy
Sigma-Aldrich Y0001924 Nicardipine hydrochloride European Pharmacopoeia (EP) Reference Standard 54527-84-3 Y0001924 $148 2023-06-20 Buy
Sigma-Aldrich Y0001917 Nicardipine for system suitability European Pharmacopoeia (EP) Reference Standard 54527-84-3 Y0001917 $201 2023-06-20 Buy
Product number Packaging Price Buy
N7510 1g $132 Buy
PHR2531 500MG $267 Buy
1463224 200mg $436 Buy
Y0001924 Y0001924 $148 Buy
Y0001917 Y0001917 $201 Buy

Nicardipine hydrochloride Chemical Properties,Uses,Production

Description

Nicardipine is a dihydropyridine L-type calcium channel antagonist that displays antihypertensive and antianginal activity. It is reported to inhibit adenosine A1, A2A, and A3 receptors with Ki values of 19.6, 63.8, and 3.25 μM, respectively, and can inhibit cytochrome P450 3A4 catalytic activity with an IC50 value of 0.148 μM. Additionally, nicardipine has been shown to activate transient receptor potential A1 channels, producing an increase in Ca2+ (EC50 = 0.5 μM).

Chemical Properties

Yellow Solid

Uses

Dihydropyridine calcium channel blocker. Antianginal; antihypertensive

Uses

Nicardipine is a dihydropyridine L-type calcium channel antagonist that displays antihypertensive and antianginal activity. It is reported to inhibit adenosine A1, A2A, and A3 receptors with Ki values of 19.6, 63.8, and 3.25 μM, respectively, and can inhibit cytochrome P450 3A4 catalytic activity with an IC50 value of 0.148 μM. Additionally, nicardipine has been shown to activate transient receptor potential A1 channels, producing an increase in Ca2+ (EC50 = 0.5 μM).

Uses

anesthetic (topical)

Definition

ChEBI: Nicardipine hydrochloride is a dihydropyridine. It has a role as a geroprotector.

brand name

Cardene(PDL Biopharma); Cardene (Roche).

General Description

Nicardipine hydrochloride,1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylicacid methyl 2-[methyl(phenylmethyl)amino]ethylester hydrochloride (Cardene), is a more potent vasodilator ofthe systemic, coronary, cerebral, and renal vasculature andhas been used in the treatment of mild, moderate, and severehypertension. The drug is also used in the management of stableangina.

Biochem/physiol Actions

Blocks L-type voltage-dependent calcium channels; antihypertensive.

Clinical Use

Calcium-channel blocker:
Prophylaxis and treatment of angina
Mild to moderate hypertension
Acute life-threatening hypertension and post operative hypertension (IV)

Safety Profile

Poison by ingestion, intravenous, and intraperitoneal routes. Moderately toxic by subcutaneous route. Human systemic effects: decreased urine volume or anuria. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx an

Drug interactions

Potentially hazardous interactions with other drugs
Aminophylline: possibly increases aminophylline concentration.
Anaesthetics: enhanced hypotensive effect.
Antibacterials: metabolism possibly accelerated by rifampicin; metabolism possibly inhibited by clarithromycin, erythromycin and telithromycin.
Antidepressants: enhanced hypotensive effect with MAOIs.
Antiepileptics: effect reduced by carbamazepine, barbiturates, phenytoin and primidone.
Antifungals: metabolism possibly inhibited by itraconazole and ketoconazole; negative inotropic effect possibly increased with itraconazole.
Antihypertensives: enhanced hypotensive effect, increased risk of first dose hypotensive effect of post synaptic alpha-blockers.
Antivirals: concentration possibly increased by ritonavir; use telaprevir with caution.
Cardiac glycosides: digoxin concentration increased.
Ciclosporin: concentration of ciclosporin increased
Grapefruit juice: concentration increased - avoid.
Tacrolimus: may increase tacrolimus levels.
Theophylline: possibly increased theophylline concentration.

Metabolism

Nicardipine is subject to saturable first-pass metabolism. It is extensively metabolised in the liver and excreted in the urine and faeces, mainly as inactive metabolites.

References

1) Merck 14 6495 2) Hulubei et al. (2012), 4-Isoxazolyl-1,4-dihydropyridines exhibit binding at the multidrug-resistance transporter; Bioorg. Med. Chem., 20 6620

Nicardipine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Nicardipine hydrochloride Suppliers

Global( 317)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Yanxi Chemical Co., Ltd. 		+8617531190177 peter@yan-xi.com China 5993 58
airuikechemical co., ltd. 		+undefined86-15315557071 sales02@airuikechemical.com China 994 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21691 55
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 fandachem@gmail.com China 9348 55
Shandong chuangyingchemical Co., Ltd. 		18853181302 sale@chuangyingchem.com CHINA 5909 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49390 58
career henan chemical co 		+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
Hebei Mojin Biotechnology Co., Ltd 		+8613288715578 sales@hbmojin.com China 12456 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Supplier Advantage
Hebei Yanxi Chemical Co., Ltd. 		58
airuikechemical co., ltd. 		58
Henan Tianfu Chemical Co.,Ltd. 		55
Hangzhou FandaChem Co.,Ltd. 		55
Shandong chuangyingchemical Co., Ltd. 		58
BOC Sciences 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
Hebei Mojin Biotechnology Co., Ltd 		58
TargetMol Chemicals Inc. 		58

Related articles

View Lastest Price from Nicardipine hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
nicardipine hydrochloride pictures 2024-04-09 nicardipine hydrochloride
54527-84-3
 US $0.00-0.00 / Kg 1Kg 99.9% 200tons airuikechemical co., ltd.
Nicardipine hydrochloride pictures 2023-09-13 Nicardipine hydrochloride
54527-84-3
 US $50.00-16.00 / kg 1kg 0.99 20 tons Hebei Yanxi Chemical Co., Ltd.
Nicardipine hydrochloride pictures 2023-09-06 Nicardipine hydrochloride
54527-84-3
 US $0.00 / KG 1KG 99% 500000kg Hebei Guanlang Biotechnology Co., Ltd.

Nicardipine hydrochloride Spectrum

Nicardipine hydrochloride(54527-84-3)MSNicardipine hydrochloride(54527-84-3)1HNMRNicardipine hydrochloride(54527-84-3)13CNMRNicardipine hydrochloride(54527-84-3)IR1Nicardipine hydrochloride(54527-84-3)IR2

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methyl 2-(benzyl-methyl-amino)ethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride 2-(benzylmethylamino)ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylatemonohydrochloride Naratriptan HCl 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid Methyl 2-[Methyl(phenylmethyl)amino]ethyl Ester Hydrochloride Antagonyl Barizin Dacarel Vasonas YC-93 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)methyl-2-[methyl(phenylmethyl)amino]-3,5-pyridinedicarboxylic acid ethyl ester hydrochloride Vasonase NICARDIPINE HYDROCHLORIDE (YC-93) CALCIU M CHANNEL ANTAG NICARDIPINE HYDROCHLORIDE MM(CRM STANDARD) YC-93, 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)methyl-2-[methyl(phenylmethyl)amino]-3,5-pyridinedicarboxylic acid ethyl ester hydrochloride Aprovan 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-diMethyl-4-(3-nitrophenyl)-, 3-Methyl 5-[2-[Methyl(phenylMethyl)aMino]ethyl] ester, hydrochloride 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-methyl 5-[2-[methyl(phenylmethyl)amino]ethyl] ester, hydrochloride (1:1) 5-pyridinedicarboxylicacid,1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-2-( angioglebil benzylmethylamino)ethylmethylester,monohydrochloride bionicard dafil dagan lincil loxen nicardil perdipina rs-69216 PERDIPINE NICODEL NICARDIPINE HCL NICARDIPINE HYDROCHLORIDE YC-93 HCL YC-93 HYDROCHLORIDE 1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-3,5-PYRIDINE-DICARBOXYLIC ACID 3-METHYL ESTER 5-[2-(METHYL-(BENZYL)AMINO)ETHYL] ESTER HYDROCHLORIDE 1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-3,5-PYRIDINEDICARBOXYLIC ACID METHYL 2- [METHYL-(PHENYLMETHYL)AMINO]ETHYL ESTER HYDROCHLORIDE 1,4-DIHYDRO-2,6-DIMETHYL-4-[3-NITROPHENYL]METHYL-2-[METHYL(PHENYLMETHYL)AMINO]-3,5-PYRIDINEDICARBOXYLIC ACID ETHYL ESTER HYDROCHLORIDE Nicardipine Hydrochloride, 99.0+ % (HPLC) NicardipineHydrochloride> Nicardipine for system suitability Nicardipine hydrochloride USP/EP/BP 3-(2-(Benzyl(methyl)amino)ethyl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride Antagonil, Dagan, Flusemide) Nicardipine HCl (RS69216 Nicardipine 13CD3 Hydrochloride Nicardipine HydrochlorideQ: What is Nicardipine Hydrochloride Q: What is the CAS Number of Nicardipine Hydrochloride Q: What is the storage condition of Nicardipine Hydrochloride Q: What are the applications of Nicardipine Hydrochloride Nicardipine Hydrochloride (1463224) 13C,2H3]-Nicardipine Hydrochloride Nicardipine Hydrochloride, ≥ 98.0% 54527-84-3 5427-84-3 C26H29N3O6HCl C26H30ClN3O6 C25H28ClN3O6 C26H29N3O6ClH Inhibitors and Activators Ion Channels Voltage-gated Ion Channels