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Chondroitin sulfate

CAS No.
9007-28-7
Chemical Name:
Chondroitin sulfate
Synonyms
CHONDROITIN SULPHATE;CSO;Mucopolysaccharide;Bovine chondroitin sulfate;Shark;C00607;chonsurid;Cartilage);Chondroitin suL;chondroitinsulfates
CBNumber:
CB1249888
Molecular Formula:
C13H21NO15S
Molecular Weight:
463.36854
MDL Number:
MFCD00146419
MOL File:
9007-28-7.mol
MSDS File:
SDS
Last updated:2024-03-28 16:22:27

Chondroitin sulfate Properties

storage temp. Store at RT.
form Powder
color White to Off-white
Water Solubility Soluble in water.
InChIKey KXKPYJOVDUMHGS-MULNJYDJNA-N
SMILES O1[C@@H](OC2[C@@H](O)[C@@H](OS(O)(=O)=O)O[C@@H](O)[C@@H]2NC(=O)C)[C@H](O)[C@H](O)[C@H](O)[C@H]1C(O)=O |&1:1,4,6,13,15,20,22,24,26,r|
LogP -2.177 (est)
CAS DataBase Reference 9007-28-7(CAS DataBase Reference)
EWG's Food Scores 1
NCI Dictionary of Cancer Terms cartilage; chondroitin sulfate
FDA UNII 7VZ9466BAB
ATC code M01AX25
EPA Substance Registry System Chondroitin, hydrogen sulfate (9007-28-7)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS08,GHS07
Signal word  Danger
Hazard statements  H334-H317-H332
Precautionary statements  P261-P285-P304+P341-P342+P311-P501-P261-P271-P304+P340-P312-P261-P272-P280-P302+P352-P333+P313-P321-P363-P501
Safety Statements  24/25
TSCA  Yes
HS Code  39139000

Chondroitin sulfate price More Price(17)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Alfa Aesar J60341 Chondroitin sulfate, 90+% 9007-28-7 1g $30.5 2024-03-01 Buy
Alfa Aesar J60341 Chondroitin sulfate, 90+% 9007-28-7 5g $63.7 2024-03-01 Buy
Alfa Aesar J60341 Chondroitin sulfate, 90+% 9007-28-7 25g $247 2024-03-01 Buy
TRC C433045 ChondroitinSulfate,BovineTrachea 9007-28-7 250mg $45 2021-12-16 Buy
ChemScene CS-6354 Chondroitinsulfate 9007-28-7 250mg $60 2021-12-16 Buy
Product number Packaging Price Buy
J60341 1g $30.5 Buy
J60341 5g $63.7 Buy
J60341 25g $247 Buy
C433045 250mg $45 Buy
CS-6354 250mg $60 Buy

Chondroitin sulfate Chemical Properties,Uses,Production

General Description

Chondroitin sulfate is a mixture of acid mucopolysaccharides extracted from the cartilage of pigs, cattle, chicken, and shark cartilage. According to their differences in chemical composition and structure, it is divided into A, B, C, D, E, F, H, etc. It mainly contains mucopolysaccharides such as chondroitin sulfate A and chondroitin sulfate C. Both chondroitin sulfate A and C contain D-glucuronic acid and 2-hydroperoxy group-deoxy-D-galactose, and contain equal amounts of acetyl and sulfuric acid residue. The only difference between them is the different position of sulfuric acid ester on the hexosamine residues. Chondroitin sulfate A can enhance the activity of lipase, causing the decomposition of triglyceride in chylomicron so that the blood will become clean due to the decrease of chylomicrons. It has anticoagulant and antithrombotic effect, and thus is clinically used for the treatment of coronary artery disease, elevated blood lipids and cholesterol, angina, neuralgia, myocardial ischemia and myocardial infarction embolism. It can also be used for prevention and treatment of hearing disorders and migraine caused by streptomycin, neuropathic pain, elderly pain of shoulder, backache, arthritis and hepatitis and skin cosmetics. It is reported that chondroitin sulfate can also be effective on improving and repairing of articular cartilage, synovium, keep the lubrication between the joints cartilages and making it elastic, alleviating joint pain and inflammation. Moreover, it also has special efficacy on symptoms located in tendons, ligaments, and diaphragm.
Chondroitin sulfate is also an important component of eye tissue. It can boost the water metabolism in corneal, improve the microcirculation, protect the cornea and promote the repair function of corneal tissue. It can also form a protective form in the corneal surface to prevent water evaporation which can effectively relieve visual fatigue and symptoms of dry eye; In additions to its anti-bacterial and anti-inflammatory effect, taurine can also participates in a lot of physiological activities in eye tissue and promote metabolism, alleviate visual fatigue.

Function

1. Chondroitin sulfate is mucopolysaccharides-class substance extracted from animal cartilage. It has an important role in prevention and treatment of cardiovascular disease, joint disease, and currently is an important biochemical product on the market.
2. As a health food or drugs, chondroitin sulfate has been long used to prevention and treatment of coronary heart disease, angina, myocardial infarction, coronary atherosclerosis, myocardial and ischemia with no significant side effects. It can significantly reduce the incidence and mortality of coronary heart disease. Long-term clinical application finds that the deposited fat can in the walls of arteries and veins can be effectively reduced or removed, which can significantly lower plasma cholesterol level, and thus preventing the formation of atherosclerosis.
3. Chondroitin sulfate can also be used for the treatment of neuropathic pain, nerve migraine headaches, joint pain, arthritis and scapular joint pain, pain after abdominal operation.
4. It can be used for prevention and treatment of hearing impairment caused by streptomycin, and hearing difficulties, tinnitus caused by a variety of noise with a significant effect.
5. It also has adjuvant therapy on chronic nephritis, chronic hepatitis, keratitis and corneal ulcers.
6. It is reported in recent years that, the chondroitin of shark cartilage has anti-tumor effect. In addition, chondroitin sulfate is also used for cosmetics and as healing agent of traumatic wound. Chondroitin sulfate is a kind of acidic mucopolysaccharides as an important component of ocular tissues. It can promote and improve the water metabolism of the cornea which is suitable for treating eye fatigue and dry eye syndrome.
Chondroitin sulfate supplied in Sigma Company (US)
Figure 1 Chondroitin sulfate supplied in Sigma Company (US)
The above information is edited by the Chemicalbook of Dai Xiongfeng.

Pharmacology and toxicology

Chondroitin sulfate is widely existed in human and animal cartilage. Its pharmaceutical preparation mainly contains two isomers: chondroitin sulfate A and chondroitin sulfate C. The content of chondroitin sulfate is different in animal cartilage of different breeds and ages. Its pharmacological effects performance is as follows:
Chondroitin sulfate can clear the blood lipid and lipoprotein, clear the cholesterol on blood vessels around the heart, prevent atherosclerosis and increase the turnover rate of lipids and fatty acids inside the cell.
Chondroitin sulfate can effectively prevent and treat coronary heart disease. It has effect of anti-atherosclerosis and anti-plaque formation on experimental atherosclerosis mode. It can increase the circulation of branches or lateral branches of atherosclerotic coronary artery, and can accelerate the healing, regeneration and repair of the myocardial necrosis or degeneration caused by experimental coronary artery atherosclerosis or embolism.
It can increase the biosynthesis of cell messenger RNA (mRNA) and deoxyribonucleic acid (DNA) as well as having a role in the promotion of cell metabolism.
It has a low anticoagulant activity. Chondroitin sulfate has a mild anti-clotting effect. Every mg of chondroitin sulfate A can yield equivalent anti-clotting effect to 0.45U heparin. Such anticoagulant activity is not relied on the effect of antithrombin III and it can take effect through the fibrinogen system instead.
Chondroitin sulfate also has an anti-inflammatory effect, and can accelerate the healing of wound healing and have anti-tumor effects.

Instruction on injection of chondroitin sulfate

Generic Name: Chondroitin Sulfate Injection
English name: Chondroitin Sulfate Injection
Pinyin: Liusuanruangusu Zhusheye
Dosage Form: injection
[Ingredients]chondroitin sulfate sodium salt.
[Character]Colorless or slightly yellow transparent liquid.
[Pharmacological and toxicity effect]Chondroitin sulfate is widely existed in human and animal cartilage. Its pharmaceutical preparation mainly contains two isomers: chondroitin sulfate A and chondroitin sulfate C. It has effect of anti-atherosclerosis and anti-plaque formation on experimental atherosclerosis mode. It can increase the circulation of branches or lateral branches of atherosclerotic coronary artery, and can accelerate the healing, regeneration and repair of the myocardial necrosis or degeneration caused by experimental coronary artery atherosclerosis or embolism. Chondroitin sulfate has a mild anti-clotting effect. Every mg of chondroitin sulfate A can yield equivalent anti-clotting effect to 0.45U heparin. Such anticoagulant activity is not relied on the effect of antithrombin III and it can take effect through the fibrinogen system instead.
[Pharmacokinetics]At 4 hours after administration, the plasma concentration reaches peak. The half-life is about 7 hours wherein about 50% excreted through urinary. The rank of its distribution in vivo is in turn: bone tissue, vascular walls, brain, and other connective tissue.
[Indications]Suitable for nervous headache, neuralgia, joint pain, atherosclerosis and other diseases.
[Dosage]use intramuscular injection for 1-2 times per day with 2ml once (one per time).
[Adverse reactions]Individual cases of chest tightness, nausea, and slightly bleeding gums.
[Taboo]Patients have allergy history should take the chemicals with caution.
[Note]Patients with bleeding tendency should use with caution. Stop using once the drugs traits change.
[Medication for Pregnant women and lactating women]not clear.

Chemical property

Amorphous powder with white or slightly yellow color; easily soluble in water; insoluble in organic solvents; it is hygroscopic, odorless, and tasteless.

Production method

Extract the pig laryngeal, nasal cartilage with 2% sodium hydroxide. Use crude trypsin to remove other proteins of the extract at 50 °C. Filtrate, adjust the pH of enzymatic hydrolysis solution to 6, and add ethanol to make a final ethanol concentration of 75%. Centrifuge and obtain the precipitate namely chondroitin sulfate crude product. Apply Multi-step refinement to obtain the finished product. For Pig throat, nasal cartilage count, the yield is 5%.

Physical properties

At room temperature,Chondroitin sulfate is a white powder, odorless, tasteless. It has a strong ability of water absorption. It is highly soluble in water to become a solution with high viscosity. It become unstable upon higher temperatures or acidic condition, primarily being deacetylated or being degraded into monosaccharide or smaller molecular-weight polysaccharide. Soluble in organic solvent like ethanol, acetone and ether. 

Uses

Chondroitin sulfate is used in a wide variety of areas of research such as bioengineering. It may be used as a biomaterial copolymer or surface derivatization reagent in the development of drug delivery vehicles, tissue engineering devices and bioscaffolds. Chondroitin sulfate may be used for the development of biocompatible structures such as hydrogels, sponges, biofilms, microspheres and micelles. Used in the treatment of coronary atherosclerosis, myocardial ischemia, myocardial infraction.

benefits

Chondroitin sulfate is reported to increase water-binding properties when used with hydrolyzed protein and to enhance the moisturizing effects of creams and lotions. In the skin, chondroitin sulfate is a glycosaminoglycan component.  It is also used to treat coronary atherosclerotic disease, increased blood lipids and cholesterol, arteriosclerosis, angina pectoris, myocardial ischemia, myocardial infarction embolism for patients of coronary heart disease.

Side effects

Chondroitin sulfate was generally well-tolerated and safe for long-term use. Side effects are relatively mild and most often included stomach upset and nausea.Less commonly, bloating, diarrhea, constipation, headache, swollen eyelids, leg swelling (edema), hair loss, skin rash, and irregular heartbeat (arrhythmia) have been reported. Some of these may be caused by a hypersensitivity to the beef or pork albumins in the chondroitin extract.

Chondroitin sulfate Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 500)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Duling International Trade Co. LTD
+8618032673083 sales05@hbduling.cn China 15755 58
BINBO BIOLOGICAL CO.,LTD
+8618629063126 info@binbobiological.com China 42 58
Shanghai Chinqesen Biotechnology Co., Ltd.
+86-16628886292 +86-19521323435 sales2@qschem-pharma.com China 202 58
Wuhan Boyuan Import & Export Co., LTD
+8615175982296 Mike@whby-chem.com China 981 58
Sinoway Industrial co., ltd.
0592-5800732; +8613806035118 xie@china-sinoway.com China 990 58
Shaanxi Haibo Biotechnology Co., Ltd
+86-02963020060 +86-18629295024 hibo06@xaltbio.com China 1000 58
Nantong Guangyuan Chemicl Co,Ltd
+undefined17712220823 admin@guyunchem.com China 616 58
Henan Fengda Chemical Co., Ltd
+8613613820652 info@fdachem.com China 5505 58
Sigma Audley
+86-18336680971 +86-18126314766 nova@sh-teruiop.com China 524 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21700 55

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View Lastest Price from Chondroitin sulfate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Chondroitin sulfate pictures 2024-03-27 Chondroitin sulfate
9007-28-7
US $5.00-0.10 / KG 1KG 98% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd
Vegan chondroitin sulfate pictures 2024-03-27 Vegan chondroitin sulfate
9007-28-7
US $0.00 / kg 1kg 99.8% 1000 kg BINBO BIOLOGICAL CO.,LTD
Chondroitin Sulfate / CS pictures 2024-03-26 Chondroitin Sulfate / CS
9007-28-7
US $120.00-45.00 / Kg/Bag 1Kg/Bag 99% up, High Density 20 tons Sinoway Industrial co., ltd.
poly-1(2/3)-n-acetyl-2-amino-2-deoxy-3-o-beta-d-glucopyranurosyl-4-(6)sulfonyl-d-galactose chondroitinpolysulfate chondroitinsulfates chondroitinsulfuricacid chondroitinsulfuricacids chonsurid CHONDROITINE SULPHATE CHONDROITIN HYDROGEN SULFATE CHONDROITIN SULFATE (BOVINE ORIGIN) CHONDROITIN SULFATE (BOVINE) 85% MIN. DRY BASIS Chondroitin Sodium Sulfate Ex Shark ChondroitinSulphate90%Min pharmagradeororalgrade,etc ChondroitinSulfatechicken Chondroitinsulfatefromchicken CHONDROITINSODIUMSULFATE(SHARK) C00607 CHONDROITIN SULPHATE(BOVINE,SHARK,PORCINE) Chondroitin sulfate (cow) Chondroitin Sulfate, Bovine Trachea CHONDROITIN SULFATE CONTROL SAMPLE(XRM)(PLEASE CALL) Cartilage) Chondroitin Sulphate (From Porcine Bovin Shark Chondroitin Sulphate (From Porcine Bovin,Shark,Cartilage) CHONDRITIN SULFATE: 70% CHONDROITIN SULFATE OPTHALMIC GRADE CHONDROITINESULFATEEXSHARK Chondroitin sulfate sodium salt from shark cartilage Chondroitin sulfate CHONDROITIN SULFATE CONTROL SAMPLE(XRM) CHONDROITIN SULFATE (CHICKEN, BOVIN & SHARK) ChonodroitinSulfate Chondroitin Sulphate (froM bovine) Chondroitin Sulphate (froM shark) itin sulfate sodiuM salt Chondroitin sulfate C sodiuM froM shark Injection Grade Chondroitin Sulfate (5ξ)-2-(Carboxyamino)-2-deoxy-3-O-β-D-glucopyranuronosyl-4-O-sulf o-α-L-arabino-hexopyranose Chondroitin sulfate (cattle) Chondroitin sulfate (Sha Yu) (2S,3S,4S,5R,6R)-6-[[(2R,3R,4R,5R,6R)-3-acetamido-2,5-dihydroxy-6-sulfooxy-4-oxanyl]oxy]-3,4,5-trihydroxy-2-oxanecarboxylic acid Chondroitin suL t from shark cartiL (5ξ)-2-(Carboxyamino)-2-deoxy-3-O-β-D-glucopyranuronosyl-4-O-sulfo-α-L-arabino-hexopyranose Chondroitin sulfate USP/EP/BP CHONDROITIN SULFATE, CONDROITIN SULFATE SODIUM Chondroitin Sulfate, Bovine Trachea - CAS 9007-28-7 Chondroitin 4-sulfate,≥98% Chondroitin sulfate from Pig Healthcare Supplement CAS 9007-28-7 Bovine Bone 90% Chondroitin Sulfate Chondroitin sulfate80% Chondroitin sulfate sodium salt(Porcine,Bovine and Marine Origin) Chondriotine sulphate CHONDROITIN SULPHATE Mucopolysaccharide CSO Bovine chondroitin sulfate