ChemicalBook >> CAS DataBase List >>Debio-1347

Debio-1347

CAS No.
1265229-25-1
Chemical Name:
Debio-1347
Synonyms
FF284;CS-1637;CH5183284;CH 518328;DCH5183284;Debio-1347;Zoligratinib;13C6]-Debio1347;CH5183284 (FF-284;Debio-1347:CH5183284
CBNumber:
CB12731046
Molecular Formula:
C20H16N6O
Molecular Weight:
356.38
MDL Number:
MFCD28502053
MOL File:
1265229-25-1.mol
MSDS File:
SDS
Last updated:2023-05-21 10:59:17

Debio-1347 Properties

Boiling point 775.5±55.0 °C(Predicted)
Density 1.51±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility ≥35.6 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
form solid
pka 10.51±0.10(Predicted)
CAS DataBase Reference 1265229-25-1
FDA UNII NR9ZYH80Z8

Debio-1347 price More Price(20)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 17120 CH5183284 ≥95% 1265229-25-1 1mg $49 2024-03-01 Buy
Cayman Chemical 17120 CH5183284 ≥95% 1265229-25-1 5mg $120 2024-03-01 Buy
Cayman Chemical 17120 CH5183284 ≥95% 1265229-25-1 10mg $216 2024-03-01 Buy
Cayman Chemical 17120 CH5183284 ≥95% 1265229-25-1 25mg $475 2024-03-01 Buy
TRC C291695 CH5183284 1265229-25-1 25mg $460 2021-12-16 Buy
Product number Packaging Price Buy
17120 1mg $49 Buy
17120 5mg $120 Buy
17120 10mg $216 Buy
17120 25mg $475 Buy
C291695 25mg $460 Buy

Debio-1347 Chemical Properties,Uses,Production

Uses

CH5183284 is an orally available and selective FGFR (fibroblast growth factor receptor) inhibitor acting on FGFR 1, 2, and 3.

Biological Activity

ch5183284 (debio-1347) is a selective and novel inhibitor of fgfr with ic50 value of 9.3, 7.6, 22 and 290 nm for fgfr1, fgfr2, fgfr3 and fgfr4, respectively [1].fibroblast growth factor receptors (fgfrs) are tyrosine kinases and receptors for fibroblast growth factors and consist of fgfr1, fgfr2, fgfr3 and fgfr4. in cancer, fgfr is activated by point mutations, gene amplification or chromosomal translocations/rearrangements and is involved in angiogenesis, cell growth, cell migration, invasion and metastasis [1].ch5183284 (debio-1347) is a selective and novel fgfr inhibitor. in a competitive binding assay, ch5183284 (debio-1347) binding with fgfr1, fgfr2, fgfr3, fgfr4 and kdr with kd values of 20, 20, 25, 740 and 960 nm, respectively. in dms114, snu-16 and kms11 cell lines, ch5183284 (debio-1347) (100-300 nm) inhibited autophosphorylation of fgfr1, fgfr2 and fgfr3. in cancer cell lines with the fgfr genetic alterations, ch5183284 (debio-1347) showed antiproliferative activity [1].in xenograft mouse models, ch5183284 (debio-1347) inhibited tumor growth against xenografts with fgfr genetic alterations such as kg1 (leukemia, fgfr1op-fgfr1 fusion), mfe-280 (endometrial cancer, fgfr2 s252w mutation), snu-16 (gastric cancer, fgfr2 amplification), rt112/84 (bladder cancer, fgfr3-tacc3 fusion) and um-uc-14 (bladder cancer, fgfr3 s249c mutation) by 134%, 100%, 147%, 125% and 116%, respectively [1].

Synthesis

The synthesis of Debio-1347 is as follows:
An aqueous solution (1.67 ml) of 4 M sodium hydroxide was added to an ethanol solution (17 ml) of [5-amino-1-(2-methyl-1H-benzimidazol-5-yl)-1H-pyrazol-4-yl]-(1-benzenesulfonyl-1H-indol-2-yl) methanone (87 mg). The resulting mixture was stirred at room temperature for 2 hours. The reaction mixture was poured into water. The resulting solid was collected by filtration, washed with water, and dried to give Debio-1347 (40 mg, 63%).
synthesis of Debio-1347.png

References

[1]. nakanishi y, akiyama n, tsukaguchi t, et al. the fibroblast growth factor receptor genetic status as a potential predictor of the sensitivity to ch5183284/debio 1347, a novel selective fgfr inhibitor. mol cancer ther, 2014, 13(11): 2547-2558.

1265231-79-5
1265229-25-1
Synthesis of Debio-1347 from Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-
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View Lastest Price from Debio-1347 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Debio-1347 pictures 2020-01-03 Debio-1347
1265229-25-1
US $9.80 / KG 1KG 97%-99% 1kg -1000kg Career Henan Chemical Co
  • Debio-1347 pictures
  • Debio-1347
    1265229-25-1
  • US $9.80 / KG
  • 97%-99%
  • Career Henan Chemical Co

Debio-1347 Spectrum

1265229-25-1(Debio-1347)Related Search:

Debio-1347 FF284 CH5183284 (Debio-1347) (5-amino-1-(2-methyl-3H-benzo[d]imidazol-5-yl)-1H-pyrazol-4-yl)(1H-indol-2-yl)methanone CH5183284 Debio-1347:CH5183284 CH5183284;CH-5183284;CH 5183284 CS-1637 [5-amino-1-(2-methyl-1H-benzimidazol-5-yl)-1H-pyrazol-4-yl](1H-indol-2-yl)methanone Methanone, [5-amino-1-(2-methyl-1H-benzimidazol-6-yl)-1H-pyrazol-4-yl]-1H-indol-2-yl- DCH5183284 CH-5183284 (5-amino-1-(2-methyl-1H-benzo[d]imidazol-6-yl)-1H-pyrazol-4-yl)(1H-indol-2-yl)methanone CH5183284 (FF-284 Zoligratinib (5-Amino-1-(2-methyl-1H-benzo[d]imidazol-6-yl)-1H-pyrazol-4-yl)(1H-indol-2-yl)methanone 13C6]-Debio1347 CH 518328 1265229-25-1 Inhibitors API