UK-371804
- CAS No.
- 256477-09-5
- Chemical Name:
- UK-371804
- Synonyms
- UK-371804;Urokinase inhitibor 1;Urokinase inhibitor 1;UK-371804 (Urokinase inhitibor 1);UK 371804,UK-371804,Inhibitor,PAI-1,inhibit,Plasminogen activator inhibitor-1;N-[[1-[(Aminoiminomethyl)amino]-4-chloro-7-isoquinolinyl]sulfonyl]-2-methylalanine;Alanine, N-[[1-[(aminoiminomethyl)amino]-4-chloro-7-isoquinolinyl]sulfonyl]-2-methyl-
- CBNumber:
- CB13160423
- Molecular Formula:
- C14H16ClN5O4S
- Molecular Weight:
- 385.83
- MDL Number:
- MFCD30749185
- MOL File:
- 256477-09-5.mol
| storage temp. | Store at -20°C |
|---|---|
| solubility | DMSO:5.0(Max Conc. mg/mL);2.59(Max Conc. mM) |
| form | A crystalline solid |
| CAS DataBase Reference | 256477-09-5 |
UK-371804 price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 27225 | UK 371804 | 256477-09-5 | 5mg | $97 | 2024-03-01 | Buy |
| Cayman Chemical | 27225 | UK 371804 | 256477-09-5 | 25mg | $410 | 2024-03-01 | Buy |
| Cayman Chemical | 27225 | UK 371804 | 256477-09-5 | 10mg | $184 | 2024-03-01 | Buy |
| ChemScene | CS-6457 | UK-371804 >98.0% | 256477-09-5 | 5mg | $144 | 2021-12-16 | Buy |
| ChemScene | CS-6457 | UK-371804 >98.0% | 256477-09-5 | 50mg | $780 | 2021-12-16 | Buy |
UK-371804 Chemical Properties,Uses,Production
Description
UK-371804 is a potent and selectiveurokinase-type plasmogen activator (uPA)inhibitor. It has excellent selectivityover tPA, plasmin, Factor IXa and Xa.In vitro, it is able to inhibit exogenous uPA in human chronic wound fluid (IC50=0.89 microM). In vivo, in a porcine acute excisional wound modelfollowing topical delivery, it is able to penetrate into pig wounds and inhibit exogenous uPA activity with no adverse effect on wound healing parameters. It has the potential for the treatment of chronic dermal ulcers.
References
http://www.dcchemicals.com/product_show-UK_371804.html
http://adisinsight.springer.com/drugs/800026963
Fish, P. V., et al. "Selective urokinase-type plasminogen activator inhibitors. 4. 1-(7-sulfonamidoisoquinolinyl)guanidines. "Journal of Medicinal Chemistry 50.10(2007):2341.
UK-371804 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Chengdu Henghui Pharm Tec Co. Ltd. | 13540674322 15828370308 | CHINA | 121 | 55 | |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4121 | 55 |
