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4-Amino-3-methylphenol

CAS No.
2835-99-6
Chemical Name:
4-Amino-3-methylphenol
Synonyms
4-AMINO-3-METHYLPHENOL;4-AMINO-3-CRESOL;Phenol, 4-amino-3-methyl-;p-Hydroxy-o-toluidine;3-Methyl-4-aminophenol;JAROCOL 4A3MP;4-amino-meta-;Amino-M-Cresol;4-amino-cresol;4-amino-m-creso
CBNumber:
CB1365623
Molecular Formula:
C7H9NO
Molecular Weight:
123.15
MDL Number:
MFCD00007871
MOL File:
2835-99-6.mol
MSDS File:
SDS
Last updated:2023-12-25 17:47:29

4-Amino-3-methylphenol Properties

Melting point 176-179 °C (lit.)
Boiling point 229.26°C (rough estimate)
Density 1.0877 (rough estimate)
refractive index 1.5380 (estimate)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility soluble in Methanol
form Powder
pka 10.34±0.18(Predicted)
color Brown
Water Solubility insoluble
BRN 2078803
InChIKey QGNGOGOOPUYKMC-UHFFFAOYSA-N
LogP 0.51 at 22℃
CAS DataBase Reference 2835-99-6(CAS DataBase Reference)
EWG's Food Scores 3-6
FDA UNII 12R07I1K8C
NIST Chemistry Reference 4-Amino-3-methyl phenol(2835-99-6)
EPA Substance Registry System Phenol, 4-amino-3-methyl- (2835-99-6)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS09
Signal word  Warning
Hazard statements  H302-H315-H319-H400
Precautionary statements  P273-P301+P312+P330-P302+P352-P305+P351+P338
Hazard Codes  Xn
Risk Statements  22-36/37/38-20/21/22
Safety Statements  26-37/39-36/37/39-36-24/25
RIDADR  UN3077
WGK Germany  3
RTECS  GO6826000
8-10-23
TSCA  Yes
HazardClass  9
PackingGroup  III
HS Code  29222900
NFPA 704
1
2 0

4-Amino-3-methylphenol price More Price(28)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 144894 4-Amino-3-methylphenol 97% 2835-99-6 5g $44.4 2024-03-01 Buy
Sigma-Aldrich 144894 4-Amino-3-methylphenol 97% 2835-99-6 25g $155 2024-03-01 Buy
TCI Chemical A0288 4-Amino-m-cresol >98.0%(GC)(T) 2835-99-6 25g $58 2024-03-01 Buy
Alfa Aesar B23152 4-Amino-3-methylphenol, 98% 2835-99-6 100g $157.65 2024-03-01 Buy
TRC A898190 4-Amino-3-methylphenol 2835-99-6 50g $75 2021-12-16 Buy
Product number Packaging Price Buy
144894 5g $44.4 Buy
144894 25g $155 Buy
A0288 25g $58 Buy
B23152 100g $157.65 Buy
A898190 50g $75 Buy

4-Amino-3-methylphenol Chemical Properties,Uses,Production

Description

4-Amino-3-methylphenol is a metabolite of 3-methyl-4-nitrophenol. It is a major metabolite of carcinogenic o-toluidine and causes DNA damage in the presence of Cu(II).

Chemical Properties

Light gray powder

Uses

4-Amino-3-methylphenol is a useful reagent for the synthesis of piperidine (piperazine)-amide substituted derivatives as multi-target antipsychotics.
4-Amino-3-methylphenol was used in synthesis of a new type of tweezer-molecule in which a strongly preferred binding conformation is generated by convergent, intramolecular hydrogen bonding.

Definition

ChEBI: A substituted aniline in which the aniline ring carries 4-hydroxy and 6-methyl substituents; a urinary metabolite of lidocaine.

Application

4-Amino-m-cresol is used as an oxidative hair dye at a maximum concentration of 1.5% after mixing with peroxide.

General Description

4-Amino-3-methylphenol is a metabolite of 3-methyl-4-nitrophenol. It is a major metabolite of carcinogenic o-toluidine and causes DNA damage in the presence of Cu(II).

Flammability and Explosibility

Not classified

Synthesis

The synthesis of 4-Amino-3-methylphenol is as follows:A mixture of the para-benzoquinone mono-oxime (1.26 mmol),SnCl2 (0.72 g, 3.80 mmol), 20 mL of CH2Cl2, and 0.2 mL of concentrated HCl, was heated to reflux for 16 h. The CH2Cl2 was removed under reduced pressure, and the residue was dissolved in ethyl acetate and washed with concentrated aqueous NaHCO3. The organic layer was dried over anhydrous Na2SO4 and the filtrate was concentrated under reduced pressure to afford the solid product.
synthesis of 4-Amino-m-cresol

Purification Methods

Crystallise it from 50% EtOH. [Beilstein 13 H 593, 13 IV 1698.]

4-Amino-3-methylphenol Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 399)Suppliers
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Taixing Foreign Trade Nanjing Co., Ltd.
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View Lastest Price from 4-Amino-3-methylphenol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Amino-3-methylphenol pictures 2023-12-26 4-Amino-3-methylphenol
2835-99-6
US $0.00 / kg 1kg 99% 1000000 Hebei Jingbo New Material Technology Co., Ltd
4-Amino-3-methylphenol pictures 2023-08-16 4-Amino-3-methylphenol
2835-99-6
US $20.00 / KG 1KG >99% 50000kg/Month Weijer International Trade (Hebei) Co., Ltd
4-Amino-3-methylphenol pictures 2023-06-03 4-Amino-3-methylphenol
2835-99-6
US $0.00-0.00 / kg 1kg 99% 500000kg Hebei Yibangte Import and Export Co. , Ltd.
4-amino-cresol 4-amino-m-creso 4-amino-m-cresol,4-hydroxy-o-toluidine,4-amino-3-methylphenol m-Cresol, 4-amino- 4-Amino-3-methylphenol,98% 4-amino-meta-cresol 4-Amino-m-cresol;4-Amino-3-methylphenol Amino-M-Cresol 4-Amino-m-methylphenol PARA-AMINO-META-CRESOL 4-AMino-M-cresol, 99+% 50GR 2-Amino-5-hydroxytoluene, 4-Amino-m-cresol, 4-Hydroxy-2-methylaniline 4-Amino-meta-cresol, 99+% 4-Amino-m-cresol,99+% 4-Amino-3-methylphenol 4-Hydroxy-2-methylaniline 4-AMINO-3-METHYLPHENOL FOR SYNTHESIS 4-AMino-3-Methylphenol, 99%, 99% 4-Amino-m-cresol C4-Amino-m-cresol 4-HYDROXY-2-METHYLANILINE 4-HYDROXY-O-TOLUIDINE 4-AMINO-M-CRESOL 2-AMINO-5-HYDROXYTOLUENE JAROCOL 4A3MP P-AMINO-M-CRESOL 2-Methyl-4-hydroxyaniline 4-amino-3-methyl-pheno 4-hydroxy-6-methylaniline 4-Amino-3-methylphenol, 98.5% 4-amino-meta- 4-Amino-m-cresol> 4-Amino-m-cresol(4AMC) Phenol, 4-amino-3-methyl- p-Hydroxy-o-toluidine 4-AMINO-3-METHYLPHENOL 4-AMINO-3-CRESOL 3-Methyl-4-aminophenol Dopexamine Impurity 13 2835-99-6 Phenols Oxygen Compounds Organic Building Blocks Building Blocks Aromatic Phenols