Pinacol
- CAS No.
- 76-09-5
- Chemical Name:
- Pinacol
- Synonyms
- 2,3-Dimethylbutane-2,3-diol;2,3-DIMETHYL-2,3-BUTANEDIOL;PINACONE;Pinakol;PINACOL ANHYDROUS;Picol;PINACOL;Pinacol,99%;Pinacol 98%;Pinacol >
- CBNumber:
- CB1403084
- Molecular Formula:
- C6H14O2
- Molecular Weight:
- 118.17
- MDL Number:
- MFCD00004462
- MOL File:
- 76-09-5.mol
- MSDS File:
- SDS
| Melting point | 40-43 °C (lit.) |
|---|---|
| Boiling point | 171-172 °C/739 mmHg (lit.) |
| Density | 0.967 g/cm3 (20℃) |
| refractive index | 1.4347 (estimate) |
| Flash point | 171 °F |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | alcohol: freely soluble |
| form | Crystalline Low Melting Solid |
| pka | 14.80±0.29(Predicted) |
| color | White |
| Odor | at 100.00 %. woody earthy patchouli warm bread |
| Odor Type | woody |
| Water Solubility | Soluble in hot water, alcohol, and diethyl ether. |
| Sensitive | Hygroscopic |
| Merck | 14,7439 |
| BRN | 1340501 |
| Dielectric constant | 7.4（24℃） |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents, strong bases, strong acids. |
| InChIKey | IVDFJHOHABJVEH-UHFFFAOYSA-N |
| LogP | 0.540 |
| CAS DataBase Reference | 76-09-5(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 527QE7I5CO |
| NIST Chemistry Reference | 2,3-Butanediol, 2,3-dimethyl-(76-09-5) |
| EPA Substance Registry System | 2,3-Butanediol, 2,3-dimethyl- (76-09-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H320-H303-H319-H315 | |||||||||
| Precautionary statements | P280a-P305+P351+P338-P321-P332+P313-P337+P313-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| Hazard Codes | Xi,F | |||||||||
| Risk Statements | 38-36/37/38-11 | |||||||||
| Safety Statements | 37-37/39-26 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | EK1720000 | |||||||||
| F | 3 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29053990 | |||||||||
| NFPA 704 |
|
Pinacol price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 221171 | Pinacol 98% | 76-09-5 | 5g | $36.06 | 2024-03-01 | Buy |
| Sigma-Aldrich | 221171 | Pinacol 98% | 76-09-5 | 100g | $176 | 2024-03-01 | Buy |
| Sigma-Aldrich | 8.21032 | Pinacol for synthesis | 76-09-5 | 100g | $136 | 2023-01-07 | Buy |
| TCI Chemical | D0691 | Pinacol >98.0%(GC) | 76-09-5 | 25g | $40 | 2024-03-01 | Buy |
| TCI Chemical | D0691 | Pinacol >98.0%(GC) | 76-09-5 | 100g | $80 | 2024-03-01 | Buy |
Pinacol Chemical Properties,Uses,Production
Chemical Properties
white solid
Occurrence
Has apparently not been reported to occur in nature.
Uses
Pinacol is used in the preparation of synthetic intermediates like pinacolborane, bis(pinacolato)diboron and pinacolchloroborane by reaction with boron trichloride. Further, it plays an important role as an intermediate for biologically active compounds like antiviral, antibacterial, antifungal and antituberculous.
Uses
pinacol be used as organic intermediates.
The pinacol coupling reaction with the inorganic electride [Ca2N](+)·e(−) as an electron donor in organic solvents was studied.
Pinacol is used in the synthesis of organic reagents such as alkenylphenylphosphonates and alkenylboronates.
Preparation
By the bimolecular reduction of acetone.
Definition
ChEBI: A glycol that is ethylene glycol in which all four methylene hydrogens have been replaced by methyl groups.
Synthesis Reference(s)
Chemistry Letters, 10, p. 1469, 1981
Journal of the American Chemical Society, 98, p. 1986, 1976 DOI: 10.1021/ja00423a067
Tetrahedron Letters, 21, p. 449, 1980 DOI: 10.1016/S0040-4039(00)71429-8
Toxicity evaluation
Both the acute oral LD50 value in rats and the acute dermal LD50 value in rabbits exceeded 5 g/kg (Moreno, 1975). The acute oral LD50 of pinacol for male albino mice was found to be 28-6 mmol/kg (Wenzel & Koff, 1956). Pinacol showed anticonvulsant activity for electroshock seizures and Metrazol? convulsions; the PD 50 values (a measure of the protective dose) determined 15 min after oral administration of pinacol to mice were found to be 16-4 and 3-44 mmol/kg for electroshock and Metrazol convulsions, respectively (Wenzel & Koff, 1956).
General Description
The pinacol coupling reaction with the inorganic electride [Ca2N](+)·e(?) as an electron donor in organic solvents was studied.
Metabolism
Pinacol forms a glucuronide in the rabbit (Williams, 1959), and was found highly conjugated with glucuronic acid in the urine of chinchilla rabbits following oral administration of 1.0-1.5 g pinacol/kg body weight (Gessner, Parke & Williams, 1960). Pinacol was not utilized to any significant extent by endocrine tissues from human placenta, rat ovary, rat testis or rat adrenal gland (Ferguson, Baillie, Caiman & Hart, 1966).
Purification Methods
The hydrate is rendered anhydrous by azeotropic distillation of water with *benzene. Recrystallise it from *benzene or toluene/pet ether, absolute EtOH or dry diethyl ether. It recrystallises from water to give the hexahydrate. [Beilstein 1 IV 2575.]
Pinacol Preparation Products And Raw materials
Raw materials
Preparation Products
1of5
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12453 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15371 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1807 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9352 | 55 |
| AB PharmaTech,LLC | 323-480-4688 | United States | 989 | 55 | |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +86-18949832763 | info@tnjchem.com | China | 2989 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Zhejiang ZETian Fine Chemicals Co. LTD | 18957127338 | stella@zetchem.com | China | 2141 | 58 |
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- Mar 24，2022
View Lastest Price from Pinacol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-19 | Pinacol
76-09-5
|
US $5.00 / kg | 1kg | ≥99% | 200mt/year | Jinan Finer Chemical Co., Ltd | |
 |
2023-09-06 | Pinacol
76-09-5
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | |
 |
2022-11-25 | Pinacol
76-09-5
|
US $1.00 / kg | 1kg | 99% | 300MT/month | Hebei Duling International Trade Co. LTD |