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ChemicalBook >> CAS DataBase List >>(S)-2-(6-bromobenzo[d][1,3]dioxol-5-yl)-N-(4-cyanophenyl)-1-(1-cyclohexylethyl)-1H-benzo[d]imidazole-5-carboxamide

(S)-2-(6-bromobenzo[d][1,3]dioxol-5-yl)-N-(4-cyanophenyl)-1-(1-cyclohexylethyl)-1H-benzo[d]imidazole-5-carboxamide

(S)-2-(6-bromobenzo[d][1,3]dioxol-5-yl)-N-(4-cyanophenyl)-1-(1-cyclohexylethyl)-1H-benzo[d]imidazole-5-carboxamide Structure
(S)-2-(6-bromobenzo[d][1,3]dioxol-5-yl)-N-(4-cyanophenyl)-1-(1-cyclohexylethyl)-1H-benzo[d]imidazole-5-carboxamide structure
CAS No.
2100284-59-9
Chemical Name:
(S)-2-(6-bromobenzo[d][1,3]dioxol-5-yl)-N-(4-cyanophenyl)-1-(1-cyclohexylethyl)-1H-benzo[d]imidazole-5-carboxamide
Synonyms
AZ3451;CS-2779;AZ3451 AZ-3451;AZ3451 >=98% (HPLC);AZ 3451;AZ-3451;AZ3451;AZ 3451,inhibit,Protease Activated Receptor (PAR),AZ-3451,AZ3451,Thrombin receptors,Inhibitor;2-(6-Bromo-1,3-benzodioxol-5-yl)-N-(4-cyanophenyl)-1-[(1S)-1-cyclohexylethyl]-1H-benzimidazole-5-carboxamide;1H-Benzimidazole-5-carboxamide, 2-(6-bromo-1,3-benzodioxol-5-yl)-N-(4-cyanophenyl)-1-[(1S)-1-cyclohexylethyl]-;(S)-2-(6-bromobenzo[d][1,3]dioxol-5-yl)-N-(4-cyanophenyl)-1-(1-cyclohexylethyl)-1H-benzo[d]imidazole-5-carboxamide
CBNumber:
CB14629419
Molecular Formula:
C30H27BrN4O3
Molecular Weight:
571.46
MDL Number:
MFCD31728469
MOL File:
2100284-59-9.mol
Last updated:2023-09-20 16:43:00
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(S)-2-(6-bromobenzo[d][1,3]dioxol-5-yl)-N-(4-cyanophenyl)-1-(1-cyclohexylethyl)-1H-benzo[d]imidazole-5-carboxamide Properties

Density 1.49±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: soluble
form A solid
pka 11.92±0.70(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HS Code  2934999090

(S)-2-(6-bromobenzo[d][1,3]dioxol-5-yl)-N-(4-cyanophenyl)-1-(1-cyclohexylethyl)-1H-benzo[d]imidazole-5-carboxamide price More Price(21)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 29671 AZ3451 2100284-59-9 5mg $100 2024-03-01 Buy
Cayman Chemical 29671 AZ3451 2100284-59-9 25mg $343 2024-03-01 Buy
Cayman Chemical 29671 AZ3451 2100284-59-9 1mg $32 2024-03-01 Buy
Cayman Chemical 29671 AZ3451 2100284-59-9 10mg $153 2024-03-01 Buy
Tocris 6806 AZ3451 ≥98%(HPLC) 2100284-59-9 10 $134 2021-12-16 Buy
Product number Packaging Price Buy
29671 5mg $100 Buy
29671 25mg $343 Buy
29671 1mg $32 Buy
29671 10mg $153 Buy
6806 10 $134 Buy

(S)-2-(6-bromobenzo[d][1,3]dioxol-5-yl)-N-(4-cyanophenyl)-1-(1-cyclohexylethyl)-1H-benzo[d]imidazole-5-carboxamide Chemical Properties,Uses,Production

Definition

ChEBI: AZ3451 is a member of the class of benzimidazoles that is 1H-benzimidazole substituted by (1S)-1-cyclohexylethyl, 6-bromo-1,3-benzodioxol-5-yl, and 4-(cyanoanilino)acyl groups at positions 1, 2 and 5, respectively. It is an allosteric modulator of protease-activated receptor 2 (IC50 = 23 nM) and exhibits anti-osteoarthritis properties. It has a role as an anti-inflammatory agent, a PAR2 negative allosteric modulator and an autophagy inducer. It is a secondary carboxamide, a nitrile, a member of benzimidazoles, a member of benzodioxoles and an organobromine compound.

Biological Activity

AZ3451 is a potent protease-activated receptor 2 (PAR2) antagonist that binds to a distant allosteric site outside the helical bundle with an IC50 of 23 nM.

in vitro

Antagonist AZ3451 binds to a remote allosteric site outside the helical bundle of the protease-activated receptor 2. AZ3451 is highly lipophilic, which coincides with the hydrophobic nature of the binding pocket within the membrane. Antagonist binding prevents structural rearrangements required for receptor activation and signalling.

target

TargetValue
PAR2
(Cell-free assay)		 23 nM

(S)-2-(6-bromobenzo[d][1,3]dioxol-5-yl)-N-(4-cyanophenyl)-1-(1-cyclohexylethyl)-1H-benzo[d]imidazole-5-carboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

(S)-2-(6-bromobenzo[d][1,3]dioxol-5-yl)-N-(4-cyanophenyl)-1-(1-cyclohexylethyl)-1H-benzo[d]imidazole-5-carboxamide Suppliers

Global( 51)Suppliers
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Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581 sales@chemhifuture.com China 3136 58
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Supplier Advantage
Zhejiang J&C Biological Technology Co.,Limited 		58
InvivoChem 		58
Nantong HI-FUTURE Biology Co., Ltd. 		58
Zibo Hangyu Biotechnology Development Co., Ltd 		58
LEAPCHEM CO., LTD. 		58
Aladdin Scientific 		58
ROSEWA HOLDING GROUP CO.,LIMITED 		58
Shanghai Changyu Medical Technology Co. Ltd. 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
Shanghai Lollane Biological Technology Co.,Ltd. 55

(S)-2-(6-bromobenzo[d][1,3]dioxol-5-yl)-N-(4-cyanophenyl)-1-(1-cyclohexylethyl)-1H-benzo[d]imidazole-5-carboxamide Spectrum

(S)-2-(6-bromobenzo[d][1,3]dioxol-5-yl)-N-(4-cyanophenyl)-1-(1-cyclohexylethyl)-1H-benzo[d]imidazole-5-carboxamide(2100284-59-9)1HNMR
(S)-2-(6-bromobenzo[d][1,3]dioxol-5-yl)-N-(4-cyanophenyl)-1-(1-cyclohexylethyl)-1H-benzo[d]imidazole-5-carboxamide AZ3451 CS-2779 AZ 3451;AZ-3451;AZ3451 1H-Benzimidazole-5-carboxamide, 2-(6-bromo-1,3-benzodioxol-5-yl)-N-(4-cyanophenyl)-1-[(1S)-1-cyclohexylethyl]- AZ3451 >=98% (HPLC) AZ 3451,inhibit,Protease Activated Receptor (PAR),AZ-3451,AZ3451,Thrombin receptors,Inhibitor AZ3451 AZ-3451 2-(6-Bromo-1,3-benzodioxol-5-yl)-N-(4-cyanophenyl)-1-[(1S)-1-cyclohexylethyl]-1H-benzimidazole-5-carboxamide 2100284-59-9 C30H27BrN4O3