Roxatidine
- CAS No.
- 78273-80-0
- Chemical Name:
- Roxatidine
- Synonyms
- ROXATIDINE;desacetyl-TZU-0460;Roxatidine USP/EP/BP;RoxatidineAcetateHclBase;Roxatidine in acetonitrile;ROXATIDINE ENTERPRISE STANDARD;ROXATIDINE(SUBJECTTOPATENTFREE);Benzaldehyde,5-methoxy-7-nitro-;n-{3-[3-(1-piperidinylmethyl)phenoxy]propyl}hydroxyacetamide;2-Hydroxy-N-[3-[m-(piperidinomethyl)phenoxy]propyl]acetamide
- CBNumber:
- CB1472068
- Molecular Formula:
- C17H26N2O3
- Molecular Weight:
- 306.4
- MDL Number:
- MFCD00871807
- MOL File:
- 78273-80-0.mol
- MSDS File:
- SDS
| Melting point | 59-60 °C |
|---|---|
| Boiling point | 524.3±45.0 °C(Predicted) |
| Density | 1.137±0.06 g/cm3(Predicted) |
| storage temp. | -20° |
| solubility | Soluble in DMSO (up to 25 mg/ml). |
| pka | 13.34±0.10(Predicted) |
| form | oil |
| color | Colorless to pale yellow |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| CAS DataBase Reference | 78273-80-0(CAS DataBase Reference) |
| FDA UNII | IV9VHT3YUM |
| ATC code | A02BA06 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
| NFPA 704 |
|
Roxatidine Chemical Properties,Uses,Production
Description
Roxatidine (78273-80-0) is a novel histamine H2 receptor antagonist.1?Suppresses inflammatory responses via inhibition of NFκB and p38 MAPK activation in LPS-induced RAW 264.7 macrophages.2?Clinically useful agent for prevention and healing of gastric and duodenal ulcers and bleeding.3?Attenuates degradation of extracellular matrix in osteoarthritis models by inactivating the NFkB pathway.4
Uses
Anti-ulcerative.
References
1) Mills and Wood (1989),?The pharmacology of histamine H2-receptor antagonists; Methods Find. Exp. Clin. Pharmacol., 11 Suppl. 1?87 2) Cho?et al. (2011), Roxatidine suppresses inflammatory responses via inhibition of NF-κB and p38 MAPK activation in LPS-induced RAW 264.7 macrophages; J. Cell. Biochem.,?112?3648 3) Imaeda?et al.?(2011),?Effect of lansoprazole versus roxatidine on prevention of bleeding and promotion of ulcer healing after endoscopic submucosal dissection for superficial gastric neoplasia; J. Gastroenterol.,?46?1267 4) Ze?et al. (2017),?Roxatidine Attenuates Degradation of Extracellular Matrix;?Biomed. Pharmacother.,?95?1156
Roxatidine Preparation Products And Raw materials
Roxatidine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 7838 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569265 +86-18612256290 | 1056@dideu.com | China | 3791 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5993 | 58 |
| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17367 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9553 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29474 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 | info@afinechem.com | CHINA | 15377 | 58 |
| Sinoway Industrial co., ltd. | 0592-5800732; +8613806035118 | xie@china-sinoway.com | China | 992 | 58 |
View Lastest Price from Roxatidine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-09-06 | Roxatidine
78273-80-0
|
US $0.00-0.00 / KG | 1KG | 99% | 500000kg | Hebei Guanlang Biotechnology Co., Ltd. | |
 |
2021-08-03 | Roxatidine USP/EP/BP
78273-80-0
|
US $1.10 / g | 1g | 0.999 | 100 Tons min | Dideu Industries Group Limited | |
 |
2021-07-20 | Roxatidine
78273-80-0
|
US $1.00-1.00 / Kg/Bag | 1g | 99% | 50tons | Shaanxi Dideu Medichem Co. Ltd |
-
- Roxatidine
78273-80-0
- US $0.00-0.00 / KG
- 99%
- Hebei Guanlang Biotechnology Co., Ltd.
-
- Roxatidine USP/EP/BP
78273-80-0
- US $1.10 / g
- 0.999
- Dideu Industries Group Limited
-
- Roxatidine
78273-80-0
- US $1.00-1.00 / Kg/Bag
- 99%
- Shaanxi Dideu Medichem Co. Ltd