DMG-PEG 2000
- CAS No.
- 160743-62-4
- Chemical Name:
- DMG-PEG 2000
- Synonyms
- DMG-PEG;mPEG-DMG;DMG-PEG 2000;DMG-mPEG2000;DMG-PEG PEG5000;DMG-PEG PEG 2000;DMG-PEG PEG10000;DMG-PEG PEG40000;DMG-PEG PEG30000;DMG-PEG PEG200000
- CBNumber:
- CB14740239
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
| storage temp. | -20°C, sealed storage, away from moisture and light |
|---|---|
| solubility | DMSO: 100 mg/mL |
| form | A crystalline solid |
| FDA UNII | 9X2596CIE0 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
DMG-PEG 2000 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| BroadPharm | BP-25496 | DMG-PEG2000 99% | 160743-62-4 | 1g | $280 | 2021-12-16 | Buy |
| BroadPharm | BP-25496 | DMG-PEG2000 99% | 160743-62-4 | 2g | $490 | 2021-12-16 | Buy |
| DC Chemicals | DC40169 | DMG-PEG2000 >98% | 160743-62-4 | 1g | $950 | 2021-12-16 | Buy |
| DC Chemicals | DC40169 | DMG-PEG2000 >98% | 160743-62-4 | 2g | $1600 | 2021-12-16 | Buy |
DMG-PEG 2000 Chemical Properties,Uses,Production
Description
DMG-PEG 2000, also called 1,2-dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000, is used for liposome preparation. DMG-PEG 2000 has become known for lipid nanoparticle (LNP) preparation for siRNA (small interfering RNA) delivery in the COVID-19 vaccine development. DMG-PEG 2000 has been used in studies for anticancer drug delivery studies for hepatocellular, gastrointestinal, neuroendocrine and adrenocortical carcinoma.
Uses
DMG-PEG2000 is used for the preparation of liposomes for siRNA delivery, which can improve the transfection efficiency. It can also be used for the preparation of lipid nanoparticles for in vivo delivery of orally administered plasmid DNA. DMG-PEG2000 can improve the mucus permeability and delivery efficiency of nanoparticles.
Chemical Properties
DMG-PEG 2000 is soluble in ethanol, DMSO and chloroform:methanol (9:1) at a concentration of 5 mg/mL; store at -20°C. Generally transported on dry ice.
Application
DMG-PEG 2000 is a lipid excipient that has been used in combination with other lipids to form lipid nanoparticles (LNPs) for delivery of COVID-19 mRNA vaccines.
in vitro
NP-3 (0.05-1.6 mg/mL; 24 hours) does not decrease the cytotoxicity of cells in 293T, HepG2, A549, and HeLa cell lines, but the DPPC and DMG-PEG coated nanoparticles reduce cell cytotoxicity. In addition, the transfection efficiency of DPPC/DMG-PEG/(lPEI/DNA) nanoparticles (NP-3) in 293 cells is improved, and the maximum transfection efficiency (～76% eGFP positive cells) is observed.
in vivo
NP-3 (oral administration; 150 μg DNA per mouse; single dose) at 12, 24, and 36 h postadministration, luciferin substrate is intraperitoneally injected to verify its permeability. NP-3 group maintains high luciferase expression in the liver, lung, and intestine areas 12-24 h post-treatment.Additionally, NP-3 exhibits 1.5 times higher signal intensity than that of NP-1 or NP-2 group from 12 to 24 h postoral administration.
DMG-PEG 2000 Preparation Products And Raw materials
Raw materials
Preparation Products
DMG-PEG 2000 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| XIAMEN SINOPEG BIOTECH CO., LTD. | +86-0592-7761068 +8617350879715 | changaiwei@sinopeg.com | China | 59 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 7019 | 58 |
| Shochem(Shanghai) Co.,Ltd | 86-21-50800795 | info@shochem.com | CHINA | 288 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 12581 | 58 |
| Shanxi Xuanran Import and Export Trade Co., Ltd. | +8617735180244 | mike_yan@xuanranglobal.com | CHINA | 4022 | 58 |
| Hebei Duling International Trade Co. LTD | +8618032673083 | sales05@hbduling.cn | China | 15743 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
View Lastest Price from DMG-PEG 2000 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-06-23 | Methoxypoly(ethylene glycol) dimyristoyl glycerol
160743-62-4
|
US $0.00-0.00 / KG | 1g | 98% | 1 | XIAMEN SINOPEG BIOTECH CO., LTD. |
-
- Methoxypoly(ethylene glycol) dimyristoyl glycerol
160743-62-4
- US $0.00-0.00 / KG
- 98%
- XIAMEN SINOPEG BIOTECH CO., LTD.
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