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DS 7423)

DS 7423) structure

CAS No.: 1222104-37-1

Chemical Name:: DS 7423)

Synonyms: DS 7423);DS-7423 (DS7423;5-{8-[(3R)-4-Acetyl-3-methylpiperazin-1-yl]-6-morpholin-4-yl-9-(2,2,2-trifluoroethyl)-9H-purin-2-yl}pyrimidin-2-amine;(R)-1-(4-(2-(2-Aminopyrimidin-5-yl)-6-morpholino-9-(2,2,2-trifluoroethyl)-9H-purin-8-yl)-2-methylpiperazin-1-yl)ethan-1-one;Ethanone, 1-[(2R)-4-[2-(2-amino-5-pyrimidinyl)-6-(4-morpholinyl)-9-(2,2,2-trifluoroethyl)-9H-purin-8-yl]-2-methyl-1-piperazinyl]-;DS7423,mTOR,Phosphoinositide 3-kinase,Inhibitor,DS-7423,inhibit,PUMA,TP53,Mammalian target of Rapamycin,PI3K,OCCC,TP53AIP1,DS 7423

CBNumber:: CB14844731

Molecular Formula:: C22H27F3N10O2

Molecular Weight:: 520.51

MDL Number:: MFCD34469319

MOL File:: 1222104-37-1.mol

Last updated:2023-05-21 10:59:17

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DS 7423) Properties

Boiling point	665.3±65.0 °C(Predicted)
Density	1.61±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
pka	3.93±0.10(Predicted)

DS 7423) Chemical Properties,Uses,Production

Biological Activity

DS-7423 is a dual PI3K and mTOR inhibitor, with IC50 values of 15.6 nM, 34.9 nM for PI3Kα and mTOR, respectively. DS-7423 possesses anti-tumor activity[1][2]. DS-7423 increases TP53 expression, the level of p-TP53 on Ser-46, and induced apoptosisrelated TP53 target genes (TP53AIP1 and PUMA) in OCCC cells[1].DS-7423 also inhibits other isoforms of class I PI3K (IC50 values: PI3Kβ = 1,143 nM; PI3Kγ = 249 nM; PI3Kδ = 262 nM)[2].

References

[1]. Katsutoshi Oda, et al. Characterization of TP53 and PI3K signaling pathways as molecular targets in gynecologic malignancies. J Obstet Gynaecol Res. 2016 Jul;42(7):757-62. [2]. Tomoko Kashiyama, et al. Antitumor activity and induction of TP53-dependent apoptosis toward ovarian clear cell adenocarcinoma by the dual PI3K/mTOR inhibitor DS-7423. PLoS One. 2014 Feb 4;9(2):e87220.

DS 7423) Preparation Products And Raw materials

Raw materials

Preparation Products

DS 7423) Suppliers

Global( 23)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32686	60
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
Finetech Industry Limited	+86-27-87465837 +8618971612321	info@finetechnology-ind.com	China	9635	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3136	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
Finetech Industry Limited	027-87465837 19945049750	sales@finetechnology-ind.com	China	9636	58
Shanghai Chaolan Chemical Technology Center	QQ:65489617 15618227136	info@SuperLan-chem.com	China	9756	58
Chuzhou KeMail Chemical Technology Co., Ltd	0550-5196001 15000891977	wj520wjxby@126.com	China	1836	55

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Finetech Industry Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
Nantong HI-FUTURE Biology Co., Ltd.	58
TargetMol Chemicals Inc.	58
Aladdin Scientific	58
Finetech Industry Limited	58
Shanghai Chaolan Chemical Technology Center	58
Chuzhou KeMail Chemical Technology Co., Ltd	55

DS 7423) DS-7423 (DS7423 DS7423,mTOR,Phosphoinositide 3-kinase,Inhibitor,DS-7423,inhibit,PUMA,TP53,Mammalian target of Rapamycin,PI3K,OCCC,TP53AIP1,DS 7423 5-{8-[(3R)-4-Acetyl-3-methylpiperazin-1-yl]-6-morpholin-4-yl-9-(2,2,2-trifluoroethyl)-9H-purin-2-yl}pyrimidin-2-amine Ethanone, 1-[(2R)-4-[2-(2-amino-5-pyrimidinyl)-6-(4-morpholinyl)-9-(2,2,2-trifluoroethyl)-9H-purin-8-yl]-2-methyl-1-piperazinyl]- (R)-1-(4-(2-(2-Aminopyrimidin-5-yl)-6-morpholino-9-(2,2,2-trifluoroethyl)-9H-purin-8-yl)-2-methylpiperazin-1-yl)ethan-1-one 1222104-37-1