Bilobalide
- CAS No.
- 33570-04-6
- Chemical Name:
- Bilobalide
- Synonyms
- BILOBALID;BILOBALIDE;VITEXICARPIM;Bilobalide A;Ginkgolactone;BILOBALIDE(SH);(-)-BILOBALIDE;Bilobalide >BILOBALIDE(AHP);Bilobalide USP/EP/BP
- CBNumber:
- CB1688713
- Molecular Formula:
- C15H18O8
- Molecular Weight:
- 326.3
- MDL Number:
- MFCD00210481
- MOL File:
- 33570-04-6.mol
| Melting point | >300° |
|---|---|
| alpha | 57820 -64.3° (c = 2 in acetone) |
| Boiling point | 651.7±55.0 °C(Predicted) |
| Density | 1.56±0.1 g/cm3(Predicted) |
| storage temp. | −20°C |
| solubility | Acetone (Slightly), Methanol (Slightly) |
| pka | 11.74±0.40(Predicted) |
| color | White to Off-White |
| Merck | 14,1220 |
| Stability | Hygroscopic |
| LogP | -0.450 (est) |
| CAS DataBase Reference | 33570-04-6(CAS DataBase Reference) |
| FDA UNII | M81D2O8H7U |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS05,GHS07,GHS09 |
|---|---|
| Signal word | Danger |
| Hazard statements | H302-H315-H317-H318-H410 |
| Precautionary statements | P261-P264-P270-P272-P273-P280-P301+P312+P330-P302+P352-P305+P351+P338+P310-P333+P313-P391-P501 |
| Safety Statements | 24/25 |
| WGK Germany | 3 |
| RTECS | LV1665000 |
| F | 10 |
| HS Code | 29322090 |
Bilobalide price More Price(43)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | B9031 | (?)-Bilobalide from Ginkgo biloba leaves ≥93% (HPLC) | 33570-04-6 | 10mg | $89.6 | 2024-03-01 | Buy |
| Sigma-Aldrich | PHL89167 | (-)-Bilobalide phyproof? Reference Substance | 33570-04-6 | 10MG | $430 | 2024-03-01 | Buy |
| Sigma-Aldrich | 79593 | (?)-Bilobalide analytical standard | 33570-04-6 | 10mg | $405 | 2024-03-01 | Buy |
| Sigma-Aldrich | 00760595 | Bilobalide primary reference standard | 33570-04-6 | 10mg | $471 | 2023-01-07 | Buy |
| TCI Chemical | B4388 | Bilobalide >95.0%(GC) | 33570-04-6 | 10mg | $143 | 2024-03-01 | Buy |
Bilobalide Chemical Properties,Uses,Production
Description
Bilobalide is a sesquiterpene lactone which is found in extracts of G. biloba. It has been shown to protect against cerebral edema, decrease cortical infarct volume, and reduce cerebral ischemic damage. Bilobalide, at 10 μM, reduces the release of glycine and glutamate from hippocampal slices under ischemic conditions. It also activates the rat constitutive androstane receptor at 100 μM and increases the levels and activities of several cytochrome P450 isoforms in rat liver microsomes.
Uses
Bilobalide provides protection against learning and memory impairment by reducing free radical injury and inhibiting neuronal apoptosis in the brain cortex and hippocampal CA1 region in induced vascular dementia rats.
Uses
Reference Standard in the analysis of herbal medicinal products
Definition
ChEBI: A terpenoid trilactone found in extracts of Ginkgo biloba.
General Description
Produced and qualified by HWI pharma services GmbH.
Exact content by quantitative NMR can be found on the certificate.
Enzyme inhibitor
This plant natural product (FW = 326.30 g/mol; CAS 33570-04-6) from the gingko tree (Ginkgo biloba) is a terpene trilactone that exhibits anticonvulsant properties. Bilobalide has multiple mechanisms of action (e.g., acting as a GABAA receptor antagonist (/1), preserving mitochondrial ATP synthesis, inhibiting staurosporine-induced apoptotic damage, suppressing hypoxia-induced membrane deterioration in the brain, and increasing the expression the mitochondrial DNA-encoded COX III subunit of cytochrome c oxidase and the ND1 subunit of NADH dehydrogenase). Bilobalide was later synthesized in E. J. Corey’s laboratory in the late 1980s.
Bilobalide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +8618829768577 | gao490372054@gamil.com | China | 1250 | 58 |
| Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | qinhe02@xaltbio.com | China | 1000 | 58 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3424 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | sales@pioneerbiotech.com | China | 3000 | 58 |
| NanJing Spring & Autumn Biological Engineering CO., LTD. | +8613815430202 | sale02@cqherb.com | CHINA | 376 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
View Lastest Price from Bilobalide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-12 | Bilobalide
33570-04-6
|
US $0.00 / kg | 1kg | 98% | 2000ton | Shaanxi Haibo Biotechnology Co., Ltd | |
 |
2024-04-12 | 2,4,6-Trihydroxybenzoic acid
33570-04-6
|
US $0.00-0.00 / kg | 1kg | 98% | 2000ton | Shaanxi Haibo Biotechnology Co., Ltd | |
 |
2024-04-09 | Bilobalide
33570-04-6
|
US $0.00 / mg | 10mg | ≥98%HPLC | No limitation | Changsha Staherb Natural Ingredients Co., Ltd. |
-
- Bilobalide
33570-04-6
- US $0.00 / kg
- 98%
- Shaanxi Haibo Biotechnology Co., Ltd
-
- 2,4,6-Trihydroxybenzoic acid
33570-04-6
- US $0.00-0.00 / kg
- 98%
- Shaanxi Haibo Biotechnology Co., Ltd
-
- Bilobalide
33570-04-6
- US $0.00 / mg
- ≥98%HPLC
- Changsha Staherb Natural Ingredients Co., Ltd.