Paroxetine maleate
- CAS No.
- 64006-44-6
- Chemical Name:
- Paroxetine maleate
- Synonyms
- gf74;FG-7051;BRL-29060;fg7051maleate;PAROXETINE MALEATE;,(z)-2-butenedioate;ZoxaMide Impurity 2;Paroxetine maleate salt;Paroxetine maleate solution;3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)-3-((trans-(-)-piperidin
- CBNumber:
- CB1712562
- Molecular Formula:
- C23H24FNO7
- Molecular Weight:
- 445.44
- MDL Number:
- MFCD01742665
- MOL File:
- 64006-44-6.mol
- MSDS File:
- SDS
| Melting point | 136-138°C |
|---|---|
| alpha | D -87° (c = 5 in ethanol) |
| Flash point | 9℃ |
| storage temp. | 2-8°C |
| solubility | DMSO: ~12 mg/mL |
| form | solid |
| color | white |
| FDA UNII | F726G2563Q |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P264-P270-P301+P312-P302+P352-P305+P351+P338 |
| Hazard Codes | Xn,T,F |
| Risk Statements | 22-36/37/38-39/23/24/25-23/24/25-11 |
| Safety Statements | 26-36-45-36/37-16-7 |
| RIDADR | 3249 |
| WGK Germany | 3 |
| RTECS | TM4569300 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| Toxicity | LD50 in mice (mg/kg): 845 s.c.; 500 orally (Christensen, Squires, 1977) |
Paroxetine maleate price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P-916 | Paroxetine maleate solution 1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant? | 64006-44-6 | 1mL | $38.1 | 2024-03-01 | Buy |
| Sigma-Aldrich | P1372 | Paroxetine maleate salt ≥98% (HPLC), solid | 64006-44-6 | 10mg | $161 | 2024-03-01 | Buy |
| Sigma-Aldrich | P1372 | Paroxetine maleate salt ≥98% (HPLC), solid | 64006-44-6 | 50mg | $637 | 2024-03-01 | Buy |
| Tocris | 2141 | Paroxetinemaleate ≥99%(HPLC) | 64006-44-6 | 50 | $616 | 2021-12-16 | Buy |
| Tocris | 2141 | Paroxetinemaleate ≥99%(HPLC) | 64006-44-6 | 10 | $151 | 2021-12-16 | Buy |
Paroxetine maleate Chemical Properties,Uses,Production
Uses
Paroxetine maleate is a selective serotonin uptake inhibitor.
Definition
ChEBI: A maleate salt obtained by reaction of paroxetine with one equivalent of maleic acid. Highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (Ki = 0.05 nM). Ki values are 1.1, 350 and 1100 nM for inhibi ion of [3H]-5-HT, [3H]-l-NA and [3H]-DA uptake respectively. Displays minimal affinity for alpha1-, alpha2- or beta-adrenoceptors, 5-HT2A, 5-HT1A, D2
General Description
Paroxetine, marketed under trade names such as Paxil? or Aropax, is an SSRI antidepressant used to treat many conditions in adults from major depression and obsessive-compulsive disorder to several anxiety disorders. Suitable uses for this certified solution standard include as a starting material for calibrators and controls in LC/MS or GC/MS paroxetine testing applications such as urine drug testing, prescription monitoring, clinical toxicology, or forensic analysis.
Biological Activity
Highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (K i = 0.05 nM). K i values are 1.1, 350 and 1100 nM for inhibition of [ 3 H]-5-HT, [ 3 H]-l-NA and [ 3 H]-DA uptake respectively. Displays minimal affinity for a 1 -, a 2 - or b-adrenoceptors, 5-HT 2A , 5-HT 1A , D 2 or H 1 receptors at concentrations below 1000 nM, however displays weak affinity for muscarinic ACh receptors (K i = 42 nM). Antidepressant and anxiolytic in vivo .
Biochem/physiol Actions
Paroxetine is a strong cytochrome P450 2D6 isotype (CYP2D6) inhibitor, which reduces the effectiveness of tamoxifen. This phenylpiperidine derivative inhibits clozapine metabolism. Paroxetine is used to treat social phobia, obsessive-compulsive disorder and panic disorder. It is also used to treat the premenstrual dysphoric disorder, post-traumatic stress disorder and chronic headache.
storage
Store at RT
Paroxetine maleate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Beijing HuaMeiHuLiBiological Chemical | 010-56205725 | waley188@sohu.com | China | 12338 | 58 |
| UHN Shanghai Research & Development Co., Ltd. | 021-58958002 18930822973 | SALES@UHNSHANGHAI.COM | China | 977 | 58 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4428 | 55 |
| ChemStrong Scientific Co.,Ltd | 0755-66853366 13670046396 | sales@chem-strong.com | China | 17982 | 56 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |