Phenelzine Sulfate
- CAS No.
- 156-51-4
- Chemical Name:
- Phenelzine Sulfate
- Synonyms
- wl7;p1531;S-1544;ep-411;kalgan;alazin;N-1544A;mao-rem;alacine;alazine
- CBNumber:
- CB1719066
- Molecular Formula:
- C8H14N2O4S
- Molecular Weight:
- 234.27
- MDL Number:
- MFCD00050687
- MOL File:
- 156-51-4.mol
- MSDS File:
- SDS
| Melting point | 166.5-167.5 °C |
|---|---|
| storage temp. | 2-8°C |
| solubility | Freely soluble in water; practically insoluble in ethanol (96%) and in ether . |
| form | A solid |
| Merck | 13,7300 |
| CAS DataBase Reference | 156-51-4 |
| FDA UNII | 2681D7P965 |
| NCI Drug Dictionary | phenelzine sulfate |
| IARC | 3 (Vol. 24, Sup 7) 1987 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301 | |||||||||
| Precautionary statements | P301+P310 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | MV8750000 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 2928002500 | |||||||||
| Toxicity | LD50 orally in mice: 156 mg/kg (Gylys) | |||||||||
| NFPA 704 |
|
Phenelzine Sulfate price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P6777 | Phenelzine sulfate salt | 156-51-4 | 5g | $407 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1517006 | Phenelzine sulfate United States Pharmacopeia (USP) Reference Standard | 156-51-4 | 200mg | $436 | 2024-03-01 | Buy |
| Sigma-Aldrich | BP1166 | Phenelzine sulfate British Pharmacopoeia (BP) Reference Standard | 156-51-4 | 100MG | $231 | 2023-01-07 | Buy |
| Cayman Chemical | 23956 | Phenelzine (sulfate) ≥98% | 156-51-4 | 250mg | $81 | 2024-03-01 | Buy |
| Cayman Chemical | 23956 | Phenelzine (sulfate) ≥98% | 156-51-4 | 500mg | $120 | 2024-03-01 | Buy |
Phenelzine Sulfate Chemical Properties,Uses,Production
Chemical Properties
A white powder or pearly platelets.
Originator
Nardil ,Parke Davis, US ,1959
Uses
antihistaminic
Uses
Phenelzine Sulfate is a hydrazine derivative that is a non-selective and irreversible monoamine oxidase inhibitor (MAOI) and also inhibits GABA-transaminase (GABA-T), markedly increasing brain GABA levels. It is an antidep ressant and anxiolytic used in the treatment of major depressive disorder (MDD) as well as other neural disorders.
Definition
ChEBI: Phenelzine sulfate is an organic molecular entity.
Manufacturing Process
To a refluxing solution containing 147.5 grams of 85% hydrazine hydrate in 500 cc of ethanol was added, during a period of 5 hours, 92.5 grams of phenethylbromide (0.50 mol) in 150 cc of ethanol. Stirring and refluxing were continued for two hours. The ethanol was removed by distillation and the residue extracted repeatedly with ether. The ether was dried with potassium carbonate and the product base collected by distillation, BP 74°C/0.1 mm, yield 52.3 grams (77%). The base is reacted with sulfuric acid in propanol to give the sulfate.
brand name
Nardil (Parke-Davis).
Therapeutic Function
Psychostimulant
General Description
Phenelzine sulfate, 2-(phenylethyl)hydrazine sulfate(Nardil), is an effective antidepressant agent. A mechanismbasedinactivator, it irreversibly inactivates the enzyme orits cofactor, presumably after oxidation to the diazine,which can then break up into molecular nitrogen, a hydrogen atom, and a phenethyl free radical. The latter would bethe active species in irreversible inhibition.
Safety Profile
Poison by ingestion, intraperitoneal, intravenous, and subcutaneous routes. Human systemic effects by ingestion: wakefulness, blood pressure lowering, constipation, hepatitis, fibrous hepatitis. Experimental reproductive effects. Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. Used as a drug for the treatment of depression. When heated to decomposition it emits very toxic fumes of SOx and NOx.
Phenelzine Sulfate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29271 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33349 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | 029-81124267 15229202216 | 1073@dideu.com | China | 10011 | 58 |
View Lastest Price from Phenelzine Sulfate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-27 | Phenelzine Sulfate USP/EP/BP
156-51-4
|
US $1.10 / g | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited | |
 |
2019-07-06 | Phenelzine (sulfate)
156-51-4
|
US $1.00 / KG | 1KG | 98% | 200kg | Career Henan Chemical Co |
-
- Phenelzine Sulfate USP/EP/BP
156-51-4
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
-
- Phenelzine (sulfate)
156-51-4
- US $1.00 / KG
- 98%
- Career Henan Chemical Co