Guaifenesin
- CAS No.
- 93-14-1
- Chemical Name:
- Guaifenesin
- Synonyms
- GLYCERYL GUAIACOLATE;GUAIPHENESIN;3-(2-methoxyphenoxy)propane-1,2-diol;gge;XL-90;Robitussin;RAC GUAIFENESIN;Glyceryl guaiacyl ether;GUAIACOL GLYCEROL ETHER;Glyceryl guaiacolate ether
- CBNumber:
- CB1743199
- Molecular Formula:
- C10H14O4
- Molecular Weight:
- 198.22
- MDL Number:
- MFCD00016873
- MOL File:
- 93-14-1.mol
- MSDS File:
- SDS
| Melting point | 77-81 °C |
|---|---|
| Boiling point | 215 °C (19 mmHg) |
| Density | 1.1825 (rough estimate) |
| refractive index | 1.5550 (estimate) |
| Flash point | 215°C/19mm |
| storage temp. | 2-8°C |
| solubility | 50g/l (experimental) |
| pka | 13.53±0.20(Predicted) |
| color | White to Off-White |
| Water Solubility | 5 g/100 mL (25 ºC) |
| Merck | 14,4555 |
| BRN | 2049375 |
| InChIKey | HSRJKNPTNIJEKV-UHFFFAOYSA-N |
| LogP | 1.390 |
| CAS DataBase Reference | 93-14-1(CAS DataBase Reference) |
| EWG's Food Scores | 1-3 |
| FDA UNII | 495W7451VQ |
| ATC code | R05CA03 |
| NIST Chemistry Reference | 3-(O-methoxyphenoxy)-1,2-propanediol(93-14-1) |
| EPA Substance Registry System | Guaifenesin (93-14-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P501 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | TY8400000 | |||||||||
| Hazard Note | Harmful | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29093090 | |||||||||
| Toxicity | LD50 oral in rabbit: 2553mg/kg | |||||||||
| NFPA 704 |
|
Guaifenesin price More Price(42)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | G5627 | Guaiacol glyceryl ether ≥98% (GC) | 93-14-1 | 25g | $28.3 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1301007 | Guaifenesin United States Pharmacopeia (USP) Reference Standard | 93-14-1 | 200mg | $436 | 2024-03-01 | Buy |
| TCI Chemical | G0159 | Guaiacol Glycerol Ether >98.0%(HPLC)(E) | 93-14-1 | 25g | $30 | 2024-03-01 | Buy |
| TCI Chemical | G0159 | Guaiacol Glycerol Ether >98.0%(HPLC)(E) | 93-14-1 | 500g | $152 | 2024-03-01 | Buy |
| Alfa Aesar | A16827 | 3-(2-Methoxyphenoxy)-1,2-propanediol, 99+% | 93-14-1 | 50g | $31.65 | 2024-03-01 | Buy |
Guaifenesin Chemical Properties,Uses,Production
Description
Guaifenesin is an oral expectorant drug. The expectorant action of guaifenesin is mediated by stimulation of the gastrointestinal tract. It is a common ingredient in prescription and over-the-counter medications used to treat cough due to colds and minor upper respiratory infections. Additionally, Guaifenesin is also a centrally-acting muscle relaxant and is used routinely in combination with analgesics and sedatives in large-animal veterinary surgery.
Chemical Properties
This substance is a white crystalline powder with a melting point of 78.5-79°C and a boiling point of 215°C (2.53kPa). It is soluble in 20ml of water and ethanol, chloroform, glycerin, and dimethylformamide. It is easily soluble in benzene but insoluble in petroleum ether. It has a slightly bitter taste and a slightly particular odor.
Originator
GG Cen,Central,US,1975
History
Guaifenesin was originally derived from the guaiac tree and used by Native Americans for health purposes. Synthesis of guaifenesin was first reported in 1912. Guaifenesin has been used in the treatment of respiratory diseases since the nineteenth century. The United States’ Food and Drug Administration (FDA) approved guaifenesin for use in overthe- counter medications in 1989. Guaifenesin is widely consumed alone and combined with antihistamines, cough suppressants, and decongestants. Guaifenesin is also a centrally acting muscle relaxant and is used routinely in combination with analgesics and sedatives in large-animal veterinary surgery.
Uses
Guaifenesin is a muscle relaxant with expectorant properties often used as an expectorant to facilitate the removal of phlegm from the airways in acute respiratory tract infections. Guaifenesin comes in tablet and capsule form, as syrup, as dissolving granules, and recently as an extended-release (longacting) tablet. The tablets, capsules, dissolving granules, and syrup are usually taken with or without food every 4 h as needed. The extended-release tablet is usually taken with or without food every 12 h.
Definition
ChEBI: Guaifenesin is a member of methoxybenzenes.
Manufacturing Process
A mixture of o-methoxyphenol (57 g), glycidol (32 g) and pyridine (1 g) is warmed to 95°C at which temperature a vigorous reaction takes place. The reaction mixture is cooled to prevent the temperature rising above 110°C. When the exothermic reaction has subsided the reactants are heated at 95°C for one hour longer and then distilled under low pressure. The main fraction boils in the range 176°C to 180°C/0.5 mm. It crystallizes on cooling. Recrystallization from benzene gives the pure product, MP 78.5°C to 79.0°C.
brand name
Mucinex (Adams).
General Description
Guaifenesin is an expectorant, widely used in the treatment of cough. Its mode of action involves the alleviating of cough discomfort by increasing sputum volume and decreasing its viscosity, thus resulting in effective cough.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Mechanism of action
Guaiphenesin facilitates secretion from bronchial mucous membranes, thus relieving a cough in colds, bronchitis, and bronchial asthma.
Synthesis
Guaiphenesin, 3-(o-methoxyphenoxy)-1,2-propandiol (23.2.3), is synthesized by reacting guiacol with 3-chloropropan-1,2-diol or with glycidol.
Veterinary Drugs and Treatments
In veterinary medicine, guaifenesin is used to induce muscle relaxation
and restraint
as an adjunct to anesthesia for short procedures
(30 – 60 minutes) in large and small animal species. There are combination
oral products containing guaifenesin for treating respiratory
conditions in horses.
In human medicine, guaifenesin has long been touted as an oral
expectorant, but definitive proof of its efficacy is lacking.
Environmental Fate
Guaifenesin’s production and use as veterinary and human
medicines may result in its release to the environment through
various waste streams.
If released to air, an estimated vapor pressure of
1.5× 10–6 mm Hg at 25 ℃ indicates that guaifenesin will
exist in both the vapor and particulate phase.
Based upon an estimated Henry’s law constant of
4.4 × 10-11 atm-m3 mol-1, volatilization from moist soil
surfaces or from water surfaces are not expected to be important
fate processes for guaifenesin.
Guaifenesin is expected to have high mobility in soil based
upon an organic carbon–water partition coefficient (Koc) of
140, which indicates that it will have more solubility in water
and is less likely to adsorb onto organic matter in soil and
plants.
Toxicity evaluation
Guaifenesin is an adrenergic antagonist in a class of medications
called expectorants. It stimulates afferent receptors in the
gastric mucosa, reflexively increasing glandular secretion by the
respiratory epithelium promoting lower respiratory tract
drainage by thinning bronchial secretions, lubricating irritated
respiratory tract membranes through increased mucous flow,
and facilitating removal of viscous mucus. The onset of action
appears to be within 15–30 min. Guaifenesin is believed to
alleviate cough discomfort by improving sinus and bronchial
drainage, increasing sputum volume, and decreasing sputum
viscosity, thereby promoting effective cough. In one study, the
effect of guaifenesin to increase mucociliary clearance from the
lung was greater in patients with chronic bronchitis than in
healthy subjects.
In another study, guaifenesin inhibited the cough reflex
sensitivity in subjects with an upper respiratory tract infection
(cough receptors are transiently hypersensitive), but not in
healthy volunteers. Possible mechanisms include a central
antitussive effect or a peripheral effect by increased sputum
volume serving as a physical barrier, shielding cough receptors
within the respiratory epithelium.
As a centrally acting muscle relaxant, guaifenesin is believed
to depress or block nerve impulse transmission at the internuncial
neuron level of the subcortical areas of the brain, brain
stem, and spinal cord. It also has mild analgesic and sedative
actions.
References
[1] Peter V. Dicpinigaitis and Yvonne E. Gayle, Effect of Guaifenesin on Cough Reflex Sensitivity, 2003, vol. 124, 2178-2181 DOI:10.1378/CHEST.124.6.2178
[2] Leonid Kagan, Eran Lavy and Ammon Hoffmann, Effect of mode of administration on guaifenesin pharmacokinetics and expectorant action in the rat model, Pulmonary Pharmacology & Therapeutics, 2009, vol. 22, 260-265 DOI:10.1016/j.pupt.2008.12.020
[3] Sittig's Pharmaceutical Manufacturing Encyclopedia
[4] Synthesis of Essential Drugs (2006, Elsevier)
[5] Plumb's Veterinary Drug Handbook
[6] https://pubchem.ncbi.nlm.nih.gov/compound/Guaifenesin
Guaifenesin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Guangzhou TongYi biochemistry technology Co.,LTD | +8613073028829 | mack@tongyon.com | China | 2996 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 11013 | 58 |
| airuikechemical co., ltd. | +undefined86-15315557071 | sales02@airuikechemical.com | China | 994 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ | sales03@shyrchem.com | CHINA | 738 | 60 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +86-18949832763 | info@tnjchem.com | China | 2989 | 55 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3424 | 58 |
View Lastest Price from Guaifenesin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-09 | guaifenesin
93-14-1
|
US $0.00-0.00 / kg | 1kg | 99.99% | 20 tons | airuikechemical co., ltd. | |
 |
2024-01-02 | Guaifenesin
93-14-1
|
US $55.00 / kg | 10kg | 0.99 | 20tons | Zibo Hangyu Biotechnology Development Co., Ltd | |
 |
2023-09-05 | POLYQUATERNIUM-37
93-14-1
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd |
-
- guaifenesin
93-14-1
- US $0.00-0.00 / kg
- 99.99%
- airuikechemical co., ltd.
-
- Guaifenesin
93-14-1
- US $55.00 / kg
- 0.99
- Zibo Hangyu Biotechnology Development Co., Ltd
-
- POLYQUATERNIUM-37
93-14-1
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd