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ChemicalBook >> CAS DataBase List >>8H-[1,4]Diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one, 3-[[2-chloro-5-(ethoxymethyl)-4-pyrimidinyl]oxy]-9,10,11,12-tetrahydro-10-methyl-, (10R)-

8H-[1,4]Diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one, 3-[[2-chloro-5-(ethoxymethyl)-4-pyrimidinyl]oxy]-9,10,11,12-tetrahydro-10-methyl-, (10R)-

8H-[1,4]Diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one, 3-[[2-chloro-5-(ethoxymethyl)-4-pyrimidinyl]oxy]-9,10,11,12-tetrahydro-10-methyl-, (10R)- Structure
8H-[1,4]Diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one, 3-[[2-chloro-5-(ethoxymethyl)-4-pyrimidinyl]oxy]-9,10,11,12-tetrahydro-10-methyl-, (10R)- structure
CAS No.
1887069-10-4
Chemical Name:
8H-[1,4]Diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one, 3-[[2-chloro-5-(ethoxymethyl)-4-pyrimidinyl]oxy]-9,10,11,12-tetrahydro-10-methyl-, (10R)-
Synonyms
CC-99677;Gamcemetinib;8H-[1,4]Diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one, 3-[[2-chloro-5-(ethoxymethyl)-4-pyrimidinyl]oxy]-9,10,11,12-tetrahydro-10-methyl-, (10R)-;8H-[1,4]Diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one, 3-[[2-chloro-5-(ethoxymethyl)-4-pyrimidinyl]oxy]-9,10,11,12-tetrahydro-10-methyl-, (10R)-;(15R)-5-[2-chloro-5-(ethoxymethyl)pyrimidin-4-yl]oxy-15-methyl-11-thia-6,14,17-triazatetracyclo[8.8.02?.0121?]octadeca-1(10),2(7),3,5,8,12(18)-hexaen-13-one
CBNumber:
CB18085091
Molecular Formula:
C22H20ClN5O3S
Molecular Weight:
469.94
MDL Number:
MOL File:
1887069-10-4.mol
Last updated:2023-05-21 10:59:17
Request For Quotation

8H-[1,4]Diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one, 3-[[2-chloro-5-(ethoxymethyl)-4-pyrimidinyl]oxy]-9,10,11,12-tetrahydro-10-methyl-, (10R)- Properties

storage temp. Store at -20°C
FDA UNII OS2IR8TV1O

8H-[1,4]Diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one, 3-[[2-chloro-5-(ethoxymethyl)-4-pyrimidinyl]oxy]-9,10,11,12-tetrahydro-10-methyl-, (10R)- Chemical Properties,Uses,Production

Biological Activity

CC-99677 is a potent, covalent, and irreversible inhibitor of the mitogen-activated protein (MAP) kinase-activated protein kinase-2 (MK2) pathway in both biochemical (IC50=156.3 nM) and cell based assays (EC50=89 nM). CC-99677 is extracted from patent WO2020236636, compound 1[1]. CC-99677 is a potent, covalent, and irreversible inhibitor of the mitogen-activated protein (MAP) kinase-activated protein kinase-2 (MK2) pathway in both biochemical (IC50=156.3 nM) and cell based assays (EC50=89 nM)[1].

References

[1]. WO2020236636

8H-[1,4]Diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one, 3-[[2-chloro-5-(ethoxymethyl)-4-pyrimidinyl]oxy]-9,10,11,12-tetrahydro-10-methyl-, (10R)- Preparation Products And Raw materials

Raw materials

Preparation Products

8H-[1,4]Diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one, 3-[[2-chloro-5-(ethoxymethyl)-4-pyrimidinyl]oxy]-9,10,11,12-tetrahydro-10-methyl-, (10R)- Suppliers

Global( 15)Suppliers
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Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52927 58
Suzhou ARTK Medchem Co., Ltd. 		+8618168183658 sales1@artkmedchem.com China 39009 58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		+8613720134139 orders@jknbiochem.com China 4692 58
ChemCell Biomedicine Co.,Ltd. 020-13556033878 2965585218 13556033878 chemcell@hotmail.com China 369 52
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 sales-cpd@caerulumpharma.com China 3427 58
DC Chemicals 021-58447131 13564518121 sales@dcchemicals.com China 9412 58
Changzhou Chenhong Biotechnology Co., Ltd. 0519-85788828 13775037613 sales@chemrenpharm.com China 3574 58
Xi'an Kaixin Biotechnology Co., Ltd 029-68881181 13619217766 3495811982@qq.com China 2758 58
Shanghai Tachizaki Biomedical Research Center 18014399201 sales@chemlab-tachizaki.com China 2494 58
Wuhan Jingkangen Biomedical Technology Co., Ltd 13720134139 13720134139 orders@jknbiochem.com China 5280 58
Supplier Advantage
Aladdin Scientific 		58
Suzhou ARTK Medchem Co., Ltd. 		58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		58
ChemCell Biomedicine Co.,Ltd. 52
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
DC Chemicals 58
Changzhou Chenhong Biotechnology Co., Ltd. 58
Xi'an Kaixin Biotechnology Co., Ltd 58
Shanghai Tachizaki Biomedical Research Center 58
Wuhan Jingkangen Biomedical Technology Co., Ltd 58
8H-[1,4]Diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one, 3-[[2-chloro-5-(ethoxymethyl)-4-pyrimidinyl]oxy]-9,10,11,12-tetrahydro-10-methyl-, (10R)- CC-99677 (15R)-5-[2-chloro-5-(ethoxymethyl)pyrimidin-4-yl]oxy-15-methyl-11-thia-6,14,17-triazatetracyclo[8.8.02?.0121?]octadeca-1(10),2(7),3,5,8,12(18)-hexaen-13-one Gamcemetinib 8H-[1,4]Diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one, 3-[[2-chloro-5-(ethoxymethyl)-4-pyrimidinyl]oxy]-9,10,11,12-tetrahydro-10-methyl-, (10R)- 1887069-10-4