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(R)-(-)-alpha-Methoxyphenylacetic acid

CAS No.
3966-32-3
Chemical Name:
(R)-(-)-alpha-Methoxyphenylacetic acid
Synonyms
(R)-2-Methoxy-2-phenylacetic acid;(R)-(-)-α-Methoxyphenylacetic Acid;(R)-(-)-αBenzeneacetic acid, .a;O-METHYL-D-MANDELIC ACID;O-Methyl-(R)-mandelicacid;Acetic acid, methoxyphenyl;(-)-Methoxyphenylacetic acid;(1)-(Methoxy)phenylacetic acid;(methyloxy)(phenyl)acetic acid
CBNumber:
CB2105770
Molecular Formula:
C9H10O3
Molecular Weight:
166.17
MDL Number:
MFCD00004250
MOL File:
3966-32-3.mol
MSDS File:
SDS
Last updated:2023-04-23 13:52:06

(R)-(-)-alpha-Methoxyphenylacetic acid Properties

Melting point 66-68 °C(lit.)
Boiling point 164-166°C 18mm
alpha -160.4 º (C=1, MEOH)
Density 1.1708 (rough estimate)
refractive index -147 ° (C=0.5, EtOH)
Flash point 164-166°C/18mm
storage temp. 2-8°C
solubility Chloroform, Ethanol, Methanol
form Fine Crystalline Powder or Needles
pka 3.10±0.10(Predicted)
color White
optical activity [α]20/D -150±3°, c = 0.5% in ethanol
BRN 3589257
CAS DataBase Reference 3966-32-3(CAS DataBase Reference)
FDA UNII WA8N5X9TFK
NIST Chemistry Reference (R)-(-)-«alpha»-methoxyphenylacetic acid(3966-32-3)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
HS Code  29189900
NFPA 704
0
0 0

(R)-(-)-alpha-Methoxyphenylacetic acid price More Price(28)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 248967 (R)-(?)-α-Methoxyphenylacetic acid 99% 3966-32-3 1g $208 2024-03-01 Buy
Sigma-Aldrich 65209 (R)-(?)-α-Methoxyphenylacetic acid for chiral derivatization, ≥99.0% 3966-32-3 1g $310 2022-05-15 Buy
TCI Chemical M0830 (R)-(-)-alpha-Methoxyphenylacetic Acid >98.0%(GC)(T) 3966-32-3 1g $39 2024-03-01 Buy
TCI Chemical M0830 (R)-(-)-alpha-Methoxyphenylacetic Acid >98.0%(GC)(T) 3966-32-3 5g $123 2024-03-01 Buy
Alfa Aesar L08719 (R)-(-)-alpha-Methoxyphenylacetic acid, 99% 3966-32-3 250mg $37.65 2024-03-01 Buy
Product number Packaging Price Buy
248967 1g $208 Buy
65209 1g $310 Buy
M0830 1g $39 Buy
M0830 5g $123 Buy
L08719 250mg $37.65 Buy

(R)-(-)-alpha-Methoxyphenylacetic acid Chemical Properties,Uses,Production

Chemical Properties

white fine crystalline powder or needles

Uses

(R)-(-)-α-Methoxyphenylacetic Acid is a useful synthetic intermediate. It is used as a reactant in the synthesis of dopamine receptor agonists. It can also be used to prepare hydroxytriamides as potent γ-secretase inhibitors.

General Description

(R)-(?)-α-Methoxyphenylacetic acid is a chiral derivatizating agent, which is employed for derivatizing enantiomers into diastereoisomers.

Purification Methods

Purify the acids by recrystallising from *C6H6/pet ether (b 80-100o). [Neilson & Peters J Chem Soc 1519 1962, Weizmann et al. J Am Chem Soc 70 1153 1948, Pirie & Smith J Chem Soc 338 1932, NMR: Dale & Mosher J Am Chem Soc 9 5 512 1973, for resolution: Roy & Deslongchamps Can J Chem 63 651 1985, Trost et al. J Am Chem Soc 1 0 8 4974 1986.] The racemic mixture has m 72o, b 121-122o/0.4mm, 165o/18mm (from pet ether) [Braun et al. Chem Ber 6 3 2847 1930]. [Beilstein 10 IV 566.]

(R)-(-)-alpha-Methoxyphenylacetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 171)Suppliers
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View Lastest Price from (R)-(-)-alpha-Methoxyphenylacetic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(R)-(-)-alpha-Methoxyphenylacetic acid pictures 2023-09-06 (R)-(-)-alpha-Methoxyphenylacetic acid
3966-32-3
US $0.00 / KG 1KG 99% 500000kg Hebei Guanlang Biotechnology Co., Ltd.
(R)-(-)-alpha-Methoxyphenylacetic acid pictures 2022-09-28 (R)-(-)-alpha-Methoxyphenylacetic acid
3966-32-3
US $0.00-0.00 / kg 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
(R)-(-)-alpha-Methoxyphenylacetic acid pictures 2019-07-06 (R)-(-)-alpha-Methoxyphenylacetic acid
3966-32-3
US $1.00 / kg 1kg 95%-99% as request Career Henan Chemical Co
(R)-(-)-METHOXYPHENYLACETIC ACID O-METHYL-D-MANDELIC ACID (R)-(-)-ALPHA-METHOXYPHENYLACETIC ACID (R)-ALPHA-METHOXYPHENYLACETIC ACID (R)-(-)-A-METHOXYPHENYLACETIC ACID Benzeneacetic acid, alpha-methoxy-, (R)- Acetic acid, methoxyphenyl- (8CI) Benzeneacetic acid, .a (R)-(-)-&alpha R-MINUS-A-METHOXYPHENYL ACETIC ACID O-Methyl-(R)-mandelicacid (r)-(-)-à-methoxyphenylacetic acid (R)-(-)-ALPHA-METHOXYPHENYLACETIC ACID 99% (R)-(-)-ɑ-Methoxyphenylacetic acid, 99% (2R)-2-Methoxy-2-phenylacetic acid (R)-α-Methoxybenzeneacetic acid (αR)-α-Methoxybenzeneacetic acid [R,(-)]-α-Methoxybenzeneacetic acid (R)-(-)-alpha-Methoxyphenylacetic acid,99% (R)-()-α-Methoxyphenylacetic acid,O-Methyl-D-mandelic acid (R)-(-)-alpha-Methoxyphenylacetic acid, 99% 1GR (1)-(Methoxy)phenylacetic acid (methyloxy)(phenyl)acetic acid 2-methoxy-2-phenyl-ethanoic acid Acetic acid, methoxyphenyl (R)-(-)-α-MethoxyphenylaceticAcid> Benzeneacetic acid, α-methoxy-, (αR)- ?-(-)-alpha-Methoxyphenylacetic acid (R)-2-Methoxy-2-phenylacetic acid (R)-(-)-α-Methoxyphenylacetic Acid (2S)-Methoxy(phenyl)acetic acid (-)-Methoxyphenylacetic acid 3966-32-3 e.e. / Absolute Conefiguration Determination (NMR) Enantiomer Excess & Absolute Conefiguration Determination Chiral Building Blocks Carboxylic Acids (Chiral) Derivatization Reagents Chiral Resolving Reagents Analytical Chromatography Product Catalog Chiral Derivatization Chiral Resolution Reagents Asymmetric Synthesis Analytical Chemistry Carboxylic Acids (Chiral) Chiral Building Blocks e.e. / Absolute Configuration Determination (NMR) Enantiomer Excess & Absolute Configuration Determination Synthetic Organic Chemistry