ChemicalBook >> CAS DataBase List >>5-METHYL-4-[(1R,6R)-3-METHYL-6-(1-METHYLETHENYL)-2-CYCLOHEXEN-1-YL]-1,3-BENZENEDIOL

5-METHYL-4-[(1R,6R)-3-METHYL-6-(1-METHYLETHENYL)-2-CYCLOHEXEN-1-YL]-1,3-BENZENEDIOL

CAS No.
317321-41-8
Chemical Name:
5-METHYL-4-[(1R,6R)-3-METHYL-6-(1-METHYLETHENYL)-2-CYCLOHEXEN-1-YL]-1,3-BENZENEDIOL
Synonyms
O-1602;O 1602,O1602;5-Methyl-4-[(1R,6R)-3-methyl-6-(1-cyclohexen-1-yl]-1,3-benzenediol;5-METHYL-4-[(1R,6R)-3-METHYL-6-(1-METHYLETHENYL)-2-CYCLOHEXEN-1-YL]-1,3-BENZENEDIOL;1,3-Benzenediol, 5-methyl-4-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-
CBNumber:
CB2136206
Molecular Formula:
C17H22O2
Molecular Weight:
258.36
MDL Number:
MFCD08062192
MOL File:
317321-41-8.mol
Last updated:2023-06-30 15:45:59

5-METHYL-4-[(1R,6R)-3-METHYL-6-(1-METHYLETHENYL)-2-CYCLOHEXEN-1-YL]-1,3-BENZENEDIOL Properties

Boiling point 401.6±45.0 °C(Predicted)
Density 1.073±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in methyl acetate (supplied pre-dissolved -10mg/ml)
form Powder
pka 9.92±0.45(Predicted)
FDA UNII 59F4R2N5N5

SAFETY

Risk and Safety Statements

5-METHYL-4-[(1R,6R)-3-METHYL-6-(1-METHYLETHENYL)-2-CYCLOHEXEN-1-YL]-1,3-BENZENEDIOL price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 10006803 O-1602 ≥98% 317321-41-8 1mg $29 2024-03-01 Buy
Cayman Chemical 10006803 O-1602 ≥98% 317321-41-8 5mg $109 2024-03-01 Buy
Cayman Chemical 10006803 O-1602 ≥98% 317321-41-8 10mg $162 2024-03-01 Buy
Cayman Chemical 10006803 O-1602 ≥98% 317321-41-8 25mg $302 2024-03-01 Buy
Tocris 2797 O-1602 ≥97%(HPLC) 317321-41-8 10 $227 2021-12-16 Buy
Product number Packaging Price Buy
10006803 1mg $29 Buy
10006803 5mg $109 Buy
10006803 10mg $162 Buy
10006803 25mg $302 Buy
2797 10 $227 Buy

5-METHYL-4-[(1R,6R)-3-METHYL-6-(1-METHYLETHENYL)-2-CYCLOHEXEN-1-YL]-1,3-BENZENEDIOL Chemical Properties,Uses,Production

Description

O-1602 is an agonist of GPR55 (EC50 = 13 nM in a GTPγS binding assay) and a derivative of the GPR55 agonist abnormal cannabidiol . It is selective for GPR55 over cannabinoid (CB) receptor 1 (CB1) and CB2 (EC50s = >30 μM for both in GTPγS binding assays). O-1602 (50 μM) reduces growth of Mz-ChA-1, HuCCT-1, CC-LP-1, and SG231 cholangiocarcinoma cells and reduces tumor growth in a Mz-ChA-1 mouse xenograft model when administered at a dose of 10 mg/kg per day. O-1602 increases calcium mobilization and lipogenesis in 3T3-L1 adipocytes in a concentration-dependent manner and increases food intake and fat mass in rats; however, this effect was also observed in mice lacking GPR55. O-1602 reduces movement-induced firing of nociceptive C fibers in a rat model of inflammatory joint pain. It also decreases IL-6 and TNF-α levels and myeloperoxidase activities in the plasma, lungs, and pancreas in a mouse model of acute pancreatitis.

Uses

O-1602 is an analog of cannabidiol that is a potent agonist at the GPR55 cannabinoid receptor.

Biological Activity

Analog of cannabidiol that is a potent agonist at the GPR55 cannabinoid receptor (EC 50 values are 13, > 30000 and > 30000 nM for GPR55, CB 1 and CB 2 receptors respectively). Induces activation of RhoA, cdc42 and rac1.

storage

Store at -20°C

5-METHYL-4-[(1R,6R)-3-METHYL-6-(1-METHYLETHENYL)-2-CYCLOHEXEN-1-YL]-1,3-BENZENEDIOL Preparation Products And Raw materials

Raw materials

Preparation Products

5-METHYL-4-[(1R,6R)-3-METHYL-6-(1-METHYLETHENYL)-2-CYCLOHEXEN-1-YL]-1,3-BENZENEDIOL Suppliers

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TargetMol Chemicals Inc.
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317321-41-8(5-METHYL-4-[(1R,6R)-3-METHYL-6-(1-METHYLETHENYL)-2-CYCLOHEXEN-1-YL]-1,3-BENZENEDIOL)Related Search:

5-METHYL-4-[(1R,6R)-3-METHYL-6-(1-METHYLETHENYL)-2-CYCLOHEXEN-1-YL]-1,3-BENZENEDIOL O-1602 5-Methyl-4-[(1R,6R)-3-methyl-6-(1-cyclohexen-1-yl]-1,3-benzenediol 1,3-Benzenediol, 5-methyl-4-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]- O 1602,O1602 317321-41-8 Cannabinoid receptor