2-HYDROXYOLEICACID
- CAS No.
- 56472-29-8
- Chemical Name:
- 2-HYDROXYOLEICACID
- Synonyms
- 2OHOA;Minerval;Acumapimod;-d17 Minerva-d17l;2-HYDROXYOLEICACID;α-Hydroxyoleic Acid;(Rac)-Idroxioleic acid;α-Hydroxyoleic Acid-d17;cis-2-Hydroxy-9-octadecenoic Acid;(Z)-2-Hydroxyoctadec-9-enoic acid
- CBNumber:
- CB21403596
- Molecular Formula:
- C18H34O3
- Molecular Weight:
- 298.46
- MDL Number:
- MFCD07778553
- MOL File:
- 56472-29-8.mol
- MSDS File:
- SDS
| Melting point | 47-50oC |
|---|---|
| storage temp. | room temp |
| solubility | DMSO: >20mg/mL |
| form | Solid |
| color | white to tan |
| FDA UNII | OSV3KVO1BT |
| NCI Drug Dictionary | 2-hydroxyoleic acid |
2-HYDROXYOLEICACID price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0256 | 2OHOA ≥98% (HPLC) | 56472-29-8 | 5mg | $130 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0256 | 2OHOA ≥98% (HPLC) | 56472-29-8 | 25mg | $523 | 2024-03-01 | Buy |
| TRC | H948765 | 2-HydroxyOleicAcid | 56472-29-8 | 250mg | $1295 | 2021-12-16 | Buy |
| Usbiological | 014206 | 2-Hydroxy Oleic Acid | 56472-29-8 | 25mg | $446 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0017712 | (9Z)-2-HYDROXY-9-OCTADECENOIC ACID 95.00% | 56472-29-8 | 25MG | $315 | 2021-12-16 | Buy |
2-HYDROXYOLEICACID Chemical Properties,Uses,Production
Chemical Properties
Off-White to Pale Beige Solid
Uses
An oleic acid synthetic analog that is an effective non-toxic anticancer drug with a wide spectrum against different types of cancer. An antihypertensive.
Uses
2OHOA has been used as:
- a modulator of the sphingolipid and glycerophospholipid pathway to study its effects on myelination in mice Charcot–Marie–Tooth type 1A (CMT1A) myelinopathy and myelinating dorsal root ganglia cultures
- in biophysical studies to study its effects on artificial membranes
- to study its interactions with major membrane lipid films
Definition
ChEBI: 2-hydroxyoleic acid is a 2-hydroxy fatty acid that is oleic acid which carries a hydroxy group at position 2. It is an orally bioavailable synthetic hydroxylated fatty acid which modulates the lipid content of cancer cell membranes and induces cell cycle arrest and apoptosis in several cancer cell lines. It has a role as an antineoplastic agent, an apoptosis inducer and an antihypertensive agent. It is a 2-hydroxy fatty acid, a long-chain fatty acid and a hydroxy monounsaturated fatty acid. It is functionally related to an oleic acid. It is a conjugate acid of a 2-hydroxyoleate.
Biochem/physiol Actions
2-Hydroxy oleic acid (2OHOA) is a derivative of oleic acid. It plays a role in membrane organization, alterations in?membrane fluidity, an increase of the tendency to form non-lamellar structures, and remodeling of microdomains by interacting with the lipids in membranes of pathological cells.
2-HYDROXYOLEICACID Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33349 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 94838 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
| Cato Research Chemicals Inc. | 020-81960175 | min.he@cato-chem.com | China | 1958 | 55 |
| Yichang Zhongyitai Trading Co., Ltd. | 0717-6449896 13886658719 | root@zhongyitai.com | China | 1976 | 58 |