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Fmoc-8-amino-3,6-dioxaoctanoic acid

Fmoc-8-amino-3,6-dioxaoctanoic acid structure

CAS No.: 166108-71-0

Chemical Name:: Fmoc-8-amino-3,6-dioxaoctanoic acid

Synonyms: FMOC-AEEA-OH;FMOC-AEEA;FMOC-AEEAC-OH;1-(9H-Fluoren-9-yl)-3-oxo-2,7,10-trioxa-4-azadodecan-12-oic acid;FMoc-NH-PEG2-CH2COOH;FMOC-AEEAC;FMOC-8-AMINO-3,6-DIOXAOCTANOIC ACID;Fmoc-Ado-OH;N-formylglycine t-butylester;9-FLUORENYLMETHOXYCARBONYL-8-AMINO-3,6-DIOXAOCTANOIC ACID

CBNumber:: CB2169923

Molecular Formula:: C21H23NO6

Molecular Weight:: 385.41

MDL Number:: MFCD01321015

MOL File:: 166108-71-0.mol

MSDS File:: SDS

Last updated:2024-03-13 17:46:53

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Fmoc-8-amino-3,6-dioxaoctanoic acid Properties

Melting point	90-92℃
Boiling point	631.4±45.0 °C(Predicted)
Density	1.265±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,2-8°C
solubility	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka	3.40±0.10(Predicted)
form	Crystalline Powder
color	White
InChI	InChI=1S/C21H23NO6/c23-20(24)14-27-12-11-26-10-9-22-21(25)28-13-19-17-7-3-1-5-15(17)16-6-2-4-8-18(16)19/h1-8,19H,9-14H2,(H,22,25)(H,23,24)
InChIKey	XQPYRJIMPDBGRW-UHFFFAOYSA-N
SMILES	C(O)(=O)COCCOCCNC(=O)OCC1C2=C(C=CC=C2)C2=C1C=CC=C2
CAS DataBase Reference	166108-71-0(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P271-P261-P280

Safety Statements

22-24/25

WGK Germany

HS Code

29189900

NFPA 704

	0
0		0

Fmoc-8-amino-3,6-dioxaoctanoic acid price More Price(63)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	95003	{2-[2-(Fmoc-amino)ethoxy]ethoxy}acetic acid ≥95.0% (HPLC)	166108-71-0	500mg	$234	2024-03-01	Buy
Sigma-Aldrich	8.51037	Fmoc-NH-(PEG)-COOH (9 atoms) Novabiochem?	166108-71-0	1g	$453	2024-03-01	Buy
TCI Chemical	F0719	8-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3,6-dioxa-n-octanoic Acid >97.0%(HPLC)	166108-71-0	1g	$265	2024-03-01	Buy
TCI Chemical	F0719	8-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3,6-dioxa-n-octanoic Acid >97.0%(HPLC)	166108-71-0	200mg	$89	2024-03-01	Buy
Alfa Aesar	H63641	(2-[2-(Fmoc-amino)ethoxy]ethoxy)acetic acid, 95%	166108-71-0	250mg	$114	2024-03-01	Buy

Product number	Packaging	Price	Buy
95003	500mg	$234	Buy
8.51037	1g	$453	Buy
F0719	1g	$265	Buy
F0719	200mg	$89	Buy
H63641	250mg	$114	Buy

Fmoc-8-amino-3,6-dioxaoctanoic acid Chemical Properties,Uses,Production

Uses

[2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid is a hydrophilic, heterobifunctional spacer.

Description

Fmoc-NH-PEG2-CH2COOH is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Chemical Properties

White solid

Uses

8-(Fmoc-amino)-3,6-dioxaoctanoic Acid is a hydrophilic, heterobifunctional spacer.

Uses

Hydrophillic spacer group.

Application

Fmoc-8-amino-3,6-dioxaoctanoic acid is a cleavable ADC linker for the synthesis of antibody-drug couplings (ADCs). It is also a PEG linker for the synthesis of PROTAC. It is widely used in drug delivery systems as it is mainly used to enhance the solubility or targeting of drugs and improve their bioavailability.

Fmoc-8-amino-3,6-dioxaoctanoic acid synthesis

Synthesis of Fmoc-8-amino-3,6-dioxaoctanoic acid from 9-Fluorenylmethyl chloroformate and 2-(2-(2-Aminoethoxy)ethoxy)acetic acid

Fmoc-8-amino-3,6-dioxaoctanoic acid Preparation Products And Raw materials

Raw materials

Phthalimide Triethylene glycol Hydrazinium hydroxide solution N,N-Dimethylformamide Potassium carbonate

Chromium(VI) oxide Triethylamine Tosyl chloride DBU 9-Fluorenylmethyl chloroformate

Ethyl acetate Hydrochloric acid Dichloromethane Sodium hydroxide N-(9-Fluorenylmethoxycarbonyloxy)succinimide

Sulfuric acid

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Preparation Products

Fmoc-8-amino-3,6-dioxaoctanoic acid Suppliers

Global( 428)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shandong Hengshannuode Pharmaceutical Technology Co., Ltd.	+8615065888978	admin@hsnordpharma.com	China	92	58
XIAMEN SINOPEG BIOTECH CO., LTD.	+86-0592-7761068 +8617350879715	changaiwei@sinopeg.com	China	59	58
Ningxia LabsChem Co., Ltd.	0952-9294929 +8613895679378	48472788@qq.com	China	352	58
Sichuan HongRi Pharma-Tech Co.,Ltd	+86-028-64841719 +8618980456393	daisy@enlaibio.com	China	1369	58
Suzhou Chukai Pharma Tech Co.,Ltd	+8615062531973	2279973922@qq.com	China	224	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	Mandy@hangyubiotech.com	China	11013	58
Alpha Biopharmaceuticals Co., Ltd	+86-411-39042497 +8613921981412	sales@alphabiopharm.com	China	886	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
9i LLC	+18039569191	MWan@NiNeiLab.com	United States	418	58
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9352	55

Supplier	Advantage
Shandong Hengshannuode Pharmaceutical Technology Co., Ltd.	58
XIAMEN SINOPEG BIOTECH CO., LTD.	58
Ningxia LabsChem Co., Ltd.	58
Sichuan HongRi Pharma-Tech Co.,Ltd	58
Suzhou Chukai Pharma Tech Co.,Ltd	58
Zibo Hangyu Biotechnology Development Co., Ltd	58
Alpha Biopharmaceuticals Co., Ltd	58
Capot Chemical Co.,Ltd.	60
9i LLC	58
Hangzhou FandaChem Co.,Ltd.	55

View Lastest Price from Fmoc-8-amino-3,6-dioxaoctanoic acid manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-18	Fmoc-AEEA-OH 166108-71-0	US $0.00-0.00 / kg	0.10000000149011612kg	98%;99%	1T+	Sichuan HongRi Pharma-Tech Co.,Ltd
2024-03-28	Fmoc-8-amino-3,6-dioxaoctanoic acid 166108-71-0	US $0.00 / KG	25KG	98%	Inquiry	PNP Biotech Co. Ltd
2024-01-02	[2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid 166108-71-0	US $60.00-600.00 / KG	1KG	0.99	20 tons	Zibo Hangyu Biotechnology Development Co., Ltd

Fmoc-AEEA-OH
166108-71-0
US $0.00-0.00 / kg
98%;99%
Sichuan HongRi Pharma-Tech Co.,Ltd

Fmoc-8-amino-3,6-dioxaoctanoic acid
166108-71-0
US $0.00 / KG
98%
PNP Biotech Co. Ltd

[2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid
166108-71-0
US $60.00-600.00 / KG
0.99
Zibo Hangyu Biotechnology Development Co., Ltd

Fmoc-8-amino-3,6-dioxaoctanoic acid Spectrum

[2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid(166108-71-0)FT-IR

166108-71-0(Fmoc-8-amino-3,6-dioxaoctanoic acid)Related Search:

6-Aminocaproic acid 2-Aminothiazole-4-acetic acid 4-Aminophenylacetic acid Nitrilotriacetic acid DIETHOXYMETHANE

Ethoxyethyne Glycine N-(9-Fluorenylmethoxycarbonyloxy)succinimide Ethoxyquin Ethyl 2-(Chlorosulfonyl)acetate

9-Fluorenylmethyl chloroformate Fmoc-Phe-OH Iminodiacetic acid Fmoc-Lys(Boc)-OH METHOXYCARBONYLSULFENYL CHLORIDE

Ethoxyamine hydrochloride FMOC-THR(TBU)-OL 17-Amino-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanoic Acid

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Fmoc-8-amino-3,6-dioxaoctanoic acid, Fmoc-AEEA Fmoc-PEG2-acetic acid {2-[2-(Fmoc-amino)ethoxy]ethoxy}acetic acid≥ 99% (HPLC) Fmoc-NH-(PEG)-COOH (9 atoms) Novabiochem 1-(9H-Fluoren-9-yl)-3-oxo-2,7,1-trioxa-4-azadodecan-12-oic acid 8-(FMOC-AMINO)-3,6-DIOXA-OCTANOIC ACID 8-FLUORENYLMETHOXYCARBONYLAMINO-3,6-DIOXAOCTANOIC ACID 8-(9-FLUORENYLMETHOXYCARBONYL-AMINO)-3,6-DIOXA-OCTANOIC ACID 8-(9-FLUORENYLMETHYLOXYCARBONYL-AMINO)-3,6-DIOXAOCTANOIC ACID FMOC-O2OC-OH FMOC-MINI-PEG(TM) FMOC-[2-(2-AMINO-ETHOXY)-ETHOXY]-ACETIC ACID 8-(9-Fluorenylmethyloxycarbonyl-amino)-3,6-dioxaoctanoicacid,{2-[2-(Fmoc-amino)ethoxy]ethoxy}aceticacid,1-(9H-Fuoren 8-(9-FLUOROENYLMETHYLOXYCARBONYL-AMINO)-3,6-DIOXAOCTANOIC ACID Fmoc-PEG2- CH2COOH (Fmoc-AEEA) 8-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3,6-dioxa-n-octanoic Acid 8-(9-Fluorenylmethyloxycarbonyl-amino)-3,6-dioxaoctanoic acid, {2-[2-(Fmoc-amino)ethoxy]ethoxy}acetic acid, 1-(9H-Fuoren-9-yl)-3-oxo-2,7,10-trioxa-4-azadodecan-12-oic acid, Fmoc-Ado, Fmoc-AEEA 2-(2-(2-(((9H-fluoren-9-yl)Methoxy)carbonyl)ethoxy)ethoxy)acetic acid 8-(Fmoc-amino)-3,6-dioxa-n-octanoic Acid [2-[2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]ethoxy]ethoxy]acetic Acid [2-[2-[(Fmoc-amino)ethoxy]ethoxy]acetic Acid {2-[2-(FMoc-aMino)-ethoxy]-ethoxy}-acetic acid, 8-(FMoc-aMino)-3,6-dioxa-octanoic acid, FMoc-Adoa-OH [2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid ,98.5% {2-[2-(Fmoc-amino)ethoxy]ethoxy}acetic acid,8-(Fmoc-amino)-3,6-dioxaoctanoic acid FMoc-2-(2- (2-aMinoethoxy)ethoxy) acetic acid RARECHEM EM WB 0032 1-(9H-FUOREN-9-YL)-3-OXO-2,7,10-TRIOXA-4-AZADODECAN-12-OIC ACID (2-[2-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-ETHOXY]-ETHOXY)-ACETIC ACID (2-[2-(FMOC-AMINO)-ETHOXY]-ETHOXY)-ACETIC ACID 6-dioxaoctanoic acid Fmoc-8-amino-3 Fmoc-NH-(PEG)-COOH (9 atoms) MOC-AEEAC-OH [2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid, 97.0% 2-{2-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)ethoxy]ethoxy}acetic acid Fmoc-NH-PEG2-CH2COOH,Fmoc-AEEA Fmoc-AEEA 1-(9H-Fluoren-9-yl)-3-oxo-2,7,10-trioxa-4-azadodecan-12-oic acid 8-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3,6-dioxa-n-octanoicAcid> 3,6,11-Trioxa-9-azadodecanoic acid, 12-(9H-fluoren-9-yl)-10-oxo- Fmoc-AEEA/Fmoc-Mini-PEG 2-[2-(Fmoc-amino)ethoxy]ethoxy]aceticaci 8-(Fmoc-amino)-3,6-dioxa-n-octanoic Acid [2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid USP/EP/BP 9-FLUORENYLMETHOXYCARBONYL-8-AMINO-3,6-DIOXAOCTANOIC ACID FMOC-AEEA FMOC-AEEAC-OH FMOC-8-AMINO-3,6-DIOXAOCTANOIC ACID 1-(9H-Fluoren-9-yl)-3-oxo-2,7,10-trioxa-4-azadodecan-12-oic acid FMOC-AEEA-OH FMoc-NH-PEG2-CH2COOH FMOC-AEEAC N-formylglycine t-butylester Fmoc-Ado-OH Fmoc-N-Amido-PEG2-CH2COOH Fmoc-N-amido-PEG2-acetic acid Fluorene methoxycarbonyl dipolyethylene glycol acetic acid 166108-71-0 Specialty Synthesis Peptide PEGylation Peptide Synthesis