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Amino Tadalafil

Amino Tadalafil structure

CAS No.: 385769-84-6

Chemical Name:: Amino Tadalafil

Synonyms: Amino Tadanafil;Amino Tadalafil;Amino Tadalafil USP/EP/BP;Tadalafil N-Desmethyl N-Amino;Tadalafil N-Desmethyl N-Amino Impurity;Amino Tadalafil solution in Methanol, 100μg/mL;(6R,12aR)-2-amino-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-he...;Best Male Enhancement Drugs 99% Amino Tadalafil powder China manufacturer;(6R,12aR)-2-Amino-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione;(6R,12aR)-2-Amino-6-(benzo[d][1,3]dioxol-5-yl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indol-1,4-dione

CBNumber:: CB21872910

Molecular Formula:: C21H18N4O4

Molecular Weight:: 390.39

MDL Number:

MOL File:: 385769-84-6.mol

Last updated:2024-04-12 23:00:59

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Amino Tadalafil Properties

Melting point	280-282°C
Boiling point	678.9±65.0 °C(Predicted)
Density	1.60±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility	Chloroform (Slightly, Heated), DMSO (Slightly), Methanol (Slightly, Heated)
form	Solid
pka	16.70±0.40(Predicted)
color	White to Off-White
InChI	InChI=1S/C21H18N4O4/c22-24-9-18(26)25-15(21(24)27)8-13-12-3-1-2-4-14(12)23-19(13)20(25)11-5-6-16-17(7-11)29-10-28-16/h1-7,15,20,23H,8-10,22H2/t15-,20-/m1/s1
InChIKey	VUKJGAVIWMPOOJ-FOIQADDNSA-N
SMILES	N1C2=C(C=CC=C2)C2C[C@]3([H])C(=O)N(N)CC(=O)N3[C@H](C3=CC=C4OCOC4=C3)C1=2
CAS DataBase Reference	385769-84-6
FDA UNII	FY501QO030

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H332-H335
Precautionary statements	P261-P280-P305+P351+P338
Safety Statements	24/25
HS Code	29339900

Amino Tadalafil price More Price(22)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	20876	Amino Tadalafil ≥98%	385769-84-6	5mg	$63	2024-03-01	Buy
Cayman Chemical	20876	Amino Tadalafil ≥98%	385769-84-6	10mg	$117	2024-03-01	Buy
Cayman Chemical	20876	Amino Tadalafil ≥98%	385769-84-6	50mg	$335	2024-03-01	Buy
Cayman Chemical	20876	Amino Tadalafil ≥98%	385769-84-6	100mg	$547	2024-03-01	Buy
Usbiological	002553	Amino Tadalafil	385769-84-6	5mg	$418	2021-12-16	Buy

Product number	Packaging	Price	Buy
20876	5mg	$63	Buy
20876	10mg	$117	Buy
20876	50mg	$335	Buy
20876	100mg	$547	Buy
002553	5mg	$418	Buy

Amino Tadalafil Chemical Properties,Uses,Production

Description

Amino tadalafil is an analog of tadalafil , a potent inhibitor of phosphodiesterase 5 with applications in several conditions, including erectile dysfunction, pulmonary arterial hypertension, and lower urinary tract dysfunction. Amino tadalafil has been detected as an illegal adulterant in a dietary supplement marketed for “tonic effect.”

Chemical Properties

White Solid

Uses

Amino Tadalafil is a drug analog of Tadalafil that used to treatment of male erectile dysfunction drugs.

Mechanism of action

Amino tadalafil is a potent inhibitor of phosphodiesterase 5 (PDE5).PDE5, an enzyme found primarily in the smooth muscle of the corpus cavernosum, selectively cleaves and degrades cGMP to 5′-GMP. PDE5 inhibitors are similar in structure to cGMP and they competitively bind to PDE5 and inhibit cGMP hydrolysis, thus enhancing the effects of NO, resulting in prolonging an erection.

in vitro

amino-tadalafil is a structural analogue of tadalafil, the active pharmaceutical ingredient in cialis, a prescription drug approved in the us for treatment of erectile dysfunction (ed). similarly, there have also been reports of herbal or dietary supplements being adulterated with designer ed analogues such as amino-tadalafil [1].

in vivo

in rats treated with both melatonin and tadalafil, the recoveries were more pronounced than in rats given either melatonin or tadalafil alone. the icp/mean arterial pressure value in vehicle-treated rats was significantly higher than in the control group, while in the tadalafil- and tadalafil + melatonin-treated groups have returned this value had returned to control levels. in addition, as an individual treatment, and especially when combined with tadalafil, melatonin prevented spinal cord injury (sci)-induced oxidative damage to cavernosal tissues and restored ed, most likely due to its anti-oxidant effects [2].

References

[1] hadwiger me, trehy ml, ye w, moore t, allgire j, westenberger b. identification of amino-tadalafil and rimonabant in electronic cigarette products using high pressure liquid chromatography with diode array and tandem mass spectrometric detection. j chromatogr a. 2010 nov 26;1217(48):7547-55.
[2] tavuk u hh, sener te, tinay i, akbal c, er ahin m, cevik o, cadirci s, reiter rj, sener g. melatonin and tadalafil treatment improves erectile dysfunction after spinal cord injury in rats. clin exp pharmacol physiol. 2014 apr;41(4):309-16.

Amino Tadalafil Preparation Products And Raw materials

Raw materials

Preparation Products

Amino Tadalafil Suppliers

Global( 157)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Wuhan Qiami Technology Co., Ltd	+8618062705058	qiamichem@163.com	China	148	58
Wuhan senwayer century chemical Co.,Ltd	+undefined-27-86652399 +undefined13627115097	market02@senwayer.com	China	874	58
Hebei Bonster Technology Co.,Limited	+8613315996897	bsterltd.wendy@gmail.com	China	796	58
Hubei Langyou International Trading Co., Ltd	+8618874586545	linda@xrdchem.cn	China	197	58
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12456	58
Anhui Ruihan Technology Co., Ltd	+8617756083858	daisy@anhuiruihan.com	China	994	58
Shaanxi Franta Biotechnology Co., Ltd	+86-13082019107 +86-13082019107	admin@flanderff.com	China	229	58
CONTIDE BIOTECH CO.,LTD	+85253358525	xena@healthtide-api.com	China	500	58
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9348	55
Hubei XinRunde Chemical Co., Ltd.	+8615102730682	bruce@xrdchem.cn	CHINA	566	55

Supplier	Advantage
Wuhan Qiami Technology Co., Ltd	58
Wuhan senwayer century chemical Co.,Ltd	58
Hebei Bonster Technology Co.,Limited	58
Hubei Langyou International Trading Co., Ltd	58
Hebei Mojin Biotechnology Co., Ltd	58
Anhui Ruihan Technology Co., Ltd	58
Shaanxi Franta Biotechnology Co., Ltd	58
CONTIDE BIOTECH CO.,LTD	58
Hangzhou FandaChem Co.,Ltd.	55
Hubei XinRunde Chemical Co., Ltd.	55

View Lastest Price from Amino Tadalafil manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-25	Amino Tadalafil 385769-84-6	US $0.00 / G	1G	99	20	CONTIDE BIOTECH CO.,LTD
2024-03-29	Amino Tadalafil 385769-84-6	US $20.00 / kg	1kg	99	1000kg	Shaanxi Franta Biotechnology Co., Ltd
2024-03-29	Amino Tadalafil 385769-84-6	US $20.00 / kg	1kg	99	1000kg	Shaanxi Franta Biotechnology Co., Ltd

Amino Tadalafil
385769-84-6
US $0.00 / G
99
CONTIDE BIOTECH CO.,LTD

Amino Tadalafil
385769-84-6
US $20.00 / kg
99
Shaanxi Franta Biotechnology Co., Ltd

Amino Tadalafil
385769-84-6
US $20.00 / kg
99
Shaanxi Franta Biotechnology Co., Ltd

385769-84-6(Amino Tadalafil)Related Search:

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TRIMETHYLSULFOXONIUM BROMIDE vardenafil tadalafi

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Amino Tadalafil (6R,12aR)-2-Amino-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione Amino Tadalafil (6R,12Ar)-2-Amino-6-(1,3-Benzodioxol-5-Yl)-2,3,6,7,12,12A-Hexahydropyrazino[1',2':1,6]Pyrido[3,4-B]Indole-1,4-Dione Amino Tadanafil (6R,12aR)-2-Amino-6-(benzo[d][1,3]dioxol-5-yl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indol-1,4-dione (6R,12aR)-2-amino-6-(benzo[d][1,3]dioxol-5-yl)-2,3,12,12a-tetrahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4(6H,7H)-dione Best Male Enhancement Drugs 99% Amino Tadalafil powder China manufacturer Pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione, 2-amino-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-, (6R,12aR)- Tadalafil N-Desmethyl N-Amino Impurity Amino Tadalafil solution in Methanol, 100μg/mL Amino Tadalafil USP/EP/BP (6R,12aR)-2-amino-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-he... Tadalafil N-Desmethyl N-Amino 385769-84-6 Drug Analogues Intermediates & Fine Chemicals Pharmaceuticals