Cilnidipine | 132203-70-4

Cilnidipine Properties

Melting point	97-99°C
Boiling point	652.6±55.0 °C(Predicted)
Density	1.240±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	H2O: ≤2mg/mL
pka	2.61±0.70(Predicted)
form	powder
color	light yellow
Merck	14,2275
InChIKey	KJEBULYHNRNJTE-DHZHZOJOSA-N
CAS DataBase Reference	132203-70-4(CAS DataBase Reference)
FDA UNII	97T5AZ1JIP
ATC code	C08CA14

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05

Signal word

Danger

Hazard statements

H318

Precautionary statements

Hazard Codes

Risk Statements

Safety Statements

WGK Germany

3

RTECS

US7975550

HS Code

29333990

Toxicity

LD50 in male, female mice, rats (mg/kg): 5000, 5000, 5000, 4412 orally; 5000 all species s.c.; 1845, 2353, 441, 426 i.p. (Wada)

NFPA 704

	0
3		0

Cilnidipine price More Price(58)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	C1493	Cilnidipine ≥98% (HPLC), powder	132203-70-4	10mg	$173	2024-03-01	Buy
Sigma-Aldrich	C1493	Cilnidipine ≥98% (HPLC), powder	132203-70-4	50mg	$277.2	2024-03-01	Buy
TCI Chemical	C2564	Cilnidipine >98.0%(HPLC)	132203-70-4	1g	$95	2024-03-01	Buy
TCI Chemical	C2564	Cilnidipine >98.0%(HPLC)	132203-70-4	5g	$284	2024-03-01	Buy
Cayman Chemical	26080	Cilnidipine ≥98%	132203-70-4	500mg	$68	2024-03-01	Buy

Product number	Packaging	Price	Buy
C1493	10mg	$173	Buy
C1493	50mg	$277.2	Buy
C2564	1g	$95	Buy
C2564	5g	$284	Buy
26080	500mg	$68	Buy

Cilnidipine Chemical Properties,Uses,Production

Description

Clinidipine is a kind of calcium channel blocker. It is a kind of novel calcium antagonist with the blocking effect on both L-type and N-type calcium channels. It is mainly used for the treatment of hypertension. Based on its effect on both N-type and L-type calcium channel, it can dilate both arterioles and venules, further reducing the pressure in the capillary bed. In addition, cilinidipine can attenuate the platelet activation associated with catecholamines.

References

https://www.drugbank.ca/drugs/DB09232
https://en.wikipedia.org/wiki/Cilnidipine

Description

Cilnidipine is a dihydropyridine calcium antagonist introduced for the treatment of essential and severe hypertension and hypertension associated with renopathy. Cilnidipine has been demonstrated to exert a potent vasodilating effect by blocking calcium influx via dihydropyridine-sensitive, voltage-dependent calcium channels. Compared to nifedipine and nicardipine, cilnidipine is superior, especially for long-term treatment, due to its characteristics of slow onset and long duration with less cardiodepressant activity. Cilnidipine is reportedly well tolerated with low toxicity. It may also be useful in ischemic heart disease.

Description

Cilnidipine is a dihydropyridine calcium channel blocker that blocks L- and N-type high-voltage-activated calcium currents in rat hippocampal CA1 pyramidal neurons when used at a concentration of 10 μM. Cilnidipine (3 mg/kg) reduces the pressor response to acute cold stress, as well as mean blood pressure, in spontaneously hypertensive rats. It dose-dependently reduces mean blood pressure and cerebral vascular resistance without affecting cerebral blood flow in anesthetized rats at doses ranging from 3-100 μg/kg. Cilnidipine (100 μg/kg, i.p.) reduces cerebral infarction area in a rat model of focal brain ischemia.

Chemical Properties

Yellow Crystalline Solid

Originator

Fujirebio (Japan)

Uses

Cilnidipine has been used:

in cell viability assay of pheochromocytoma (nPC12) cells
in photoirradiation and photodegradation studies
to understand effect on albuminuria in diabetic nephropathy

Uses

A dihydropyridine calcium channel blocker.

Uses

antihypertensive;dihydropyridine calcium channel blocker

Definition

ChEBI: A diesterified 1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium channel blocker, it is used as an antihypertensive.

brand name

Cinalong;Siscard;Atelec

Biological Activity

Dual L- and N-type calcium channel blocker that displays antihypertensive, sympatholytic and neuroprotective activity. Lowers mean blood pressure and reduces the size of cerebral infarction in the rat model of focal brain ischemia.

Biochem/physiol Actions

Cilnidipine is a slow-acting Ca2+ channel blocker; antihypertensive; vasodilator; dual blocker of L-type voltage-gated Ca2+ channels in vascular smooth muscle and N-type Ca2+ channels in sympathetic nerve terminals that supply blood vessels. Cilnidipine may offer an advantage over nifedipine as the long term intake of the latter has been linked to increased risk of myocardial infarction and mortality in patients with coronary artery disease. Cilnidipine lowers blood pressure, but has less effect on sympathetic activity. Unlike nifedipine, cilnidipine does not inhibit PKC.

storage

+4°C

Cilnidipine Preparation Products And Raw materials

Raw materials

Methyl 3-aminocrotonate 2-Methoxyethyl 2-[(3-nitrophenyl)methylene]acetoacetate

Preparation Products

Cilnidipine Suppliers

Global( 463)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12453	58
Changzhou Rokechem Technology Co., Ltd.	18758118018	sales001@rokechem.com	China	255	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9350	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Hebei Jimi Trading Co., Ltd.	+86 319 5273535	bestoneforyou@sina.com	CHINA	288	58
Hebei Guanlang Biotechnology Co., Ltd.	+86-19930503282	alice@crovellbio.com	China	8822	58
Shandong chuangyingchemical Co., Ltd.	18853181302	sale@chuangyingchem.com	CHINA	5909	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58

Supplier	Advantage
Hebei Mojin Biotechnology Co., Ltd	58
Changzhou Rokechem Technology Co., Ltd.	58
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
career henan chemical co	58
Hebei Jimi Trading Co., Ltd.	58
Hebei Guanlang Biotechnology Co., Ltd.	58
Shandong chuangyingchemical Co., Ltd.	58
Chongqing Chemdad Co., Ltd	58
Alchem Pharmtech,Inc.	58

View Lastest Price from Cilnidipine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2023-11-01	Cilnidipine 132203-70-4	US $0.00-0.00 / kg	1kg	99.0% min	1000kgs/month	Hangzhou ICH Biofarm Co., Ltd
2023-08-16	Cilnidipine 132203-70-4	US $10.00 / KG	1KG	>99%	50000kg/Month	Weijer International Trade (Hebei) Co., Ltd
2023-08-04	Clinidipine 132203-70-4	US $0.00-0.00 / Kg	1Kg	99% USP EP CP	1-10000kgs	Changzhou Rokechem Technology Co., Ltd.

Cilnidipine
132203-70-4
US $0.00-0.00 / kg
99.0% min
Hangzhou ICH Biofarm Co., Ltd

Cilnidipine
132203-70-4
US $10.00 / KG
>99%
Weijer International Trade (Hebei) Co., Ltd

Clinidipine
132203-70-4
US $0.00-0.00 / Kg
99% USP EP CP
Changzhou Rokechem Technology Co., Ltd.

Cilnidipine Spectrum

Cilnidipine(132203-70-4)¹HNMR

132203-70-4(Cilnidipine)Related Search:

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(Trifluoromethoxy)benzene Dacthal Cilnidipine Impurity 2

1of4

(+/-)-(e)-cinnamyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate O3-(2-Methoxyethyl) O5-[(E)-3-phenylprop-2-enyl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid 3-(2-methoxyethyl)5-[(E)-3-phenyl-2-propenyl] ester 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylic acid 3-(2-methoxyethyl)5-[(E)-3-phenyl-2-propenyl] ester Frc 8653,1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl (2E)-3-phenyl-2-propenyl ester 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 2-Methoxyethyl (2E)-3-Phenyl-2-propenyl Ester 2-Methoxyethyl (2E)-3-Phenyl-2-propenyl 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate ilnidipine 3-CinnaMyl 5-(2-Methoxyethyl) 2,6-diMethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate 3-Cinnamyl 5-(2-methoxyethyl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylat 1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-3,5-PYRIDINEDICARBOXYLIC ACID 2-METHOXYETHYL (2E)-3-PHENYL-2-PROPENYL ESTER SISCARD 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-(2-methoxyethyl) 5-[(2E)-3-phenyl-2-propen-1-yl] ester 3-Cinnamyl 5-(2-methoxyethyl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxy CILNIDIPINE FRC-8653 CILNDIPINE (e)-(+-)-ethoxyethyl3-phenyl-2-propenyleste 5-pyridinedicarboxylicacid,1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-2-m Cinildipine CINILDPINE Cinidipine 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 2-Methoxyethyl (2E)-3-Phenyl-2-propenyl Ester, FRC-8653, Atelec, Cinalong, Siscard, CILNIDPINE 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-methoxyethyl (2E)-3-phenyl-2-propenyl ester 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-methoxyethyl 3-phenyl-2-propenyl ester, (E)- 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-methoxyethyl 3-phenyl-2-propenyl ester, (E)-(+-)- FRG 8653 Cilnidipine and intermediates 2,6-dimethyl-4-(3-nitrophenyl)-5-(3-phenylprop-2-enoxymethyl)-1,4-dihydropyridine-3-carboxylic acid 2-methoxyethyl ester Sidipine Cilnidipine (FRC-8653) Cilnidipine Whatsapp Cilnidipine > Cilnidipine RS nidipine 2-Methoxyethyl (2E)-3-Phenyl-2-propenyl 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate Cilnidipine USP/EP/BP CilnidipineQ: What is Cilnidipine Q: What is the CAS Number of Cilnidipine Q: What is the storage condition of Cilnidipine Cilnidipine D4 ATELEC CINALONG clinidipine CiL 13C6]-Cilnidipine Cilinidipine Cilnidipine, ≥ 98.0% 132203-70-4 Dihydropyridine Class Chemicals Intermediates & Fine Chemicals Pharmaceuticals Calcium channel API FRC 8653 Dihydropyridine APIs Active Pharmaceutical Ingredients 132203-70-4