Glutarimide
- CAS No.
- 1121-89-7
- Chemical Name:
- Glutarimide
- Synonyms
- PIPERIDINE-2,6-DIONE;NSC 58190;NSC 168666;GLUTARIMIDE;Glutarimide98%;Glutarimide>2,6-Dioxopiperidine;2,6-PIPERIDINEDIONE;2,6-DIKETOPIPERIDINE;GlutariMide, 98% 25GR
- CBNumber:
- CB2221090
- Molecular Formula:
- C5H7NO2
- Molecular Weight:
- 113.11
- MDL Number:
- MFCD00006670
- MOL File:
- 1121-89-7.mol
- MSDS File:
- SDS
| Melting point | 155-157 °C (lit.) |
|---|---|
| Boiling point | 211.82°C (rough estimate) |
| Density | 1.2416 (rough estimate) |
| refractive index | 1.4200 (estimate) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | soluble in Chloroform, DCM |
| form | Crystals or Crystalline Flakes |
| pka | pKa 11.4 (Uncertain) |
| color | White |
| Water Solubility | Soluble in water, hot ethanol and boiling benzene. Insoluble in ether. |
| BRN | 110052 |
| InChI | InChI=1S/C5H7NO2/c7-4-2-1-3-5(8)6-4/h1-3H2,(H,6,7,8) |
| InChIKey | KNCYXPMJDCCGSJ-UHFFFAOYSA-N |
| SMILES | N1C(=O)CCCC1=O |
| CAS DataBase Reference | 1121-89-7(CAS DataBase Reference) |
| EWG's Food Scores | 1-3 |
| FDA UNII | MV728O9612 |
| EPA Substance Registry System | Glutarimide (1121-89-7) |
Glutarimide price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 178098 | Glutarimide 98% | 1121-89-7 | 5g | $121 | 2024-03-01 | Buy |
| Sigma-Aldrich | 178098 | Glutarimide 98% | 1121-89-7 | 25g | $240 | 2024-03-01 | Buy |
| TCI Chemical | G0269 | Glutarimide >98.0%(N) | 1121-89-7 | 5g | $111 | 2024-03-01 | Buy |
| Alfa Aesar | L00968 | Glutarimide, 98% | 1121-89-7 | 5g | $54.65 | 2024-03-01 | Buy |
| Alfa Aesar | L00968 | Glutarimide, 98% | 1121-89-7 | 25g | $162 | 2024-03-01 | Buy |
Glutarimide Chemical Properties,Uses,Production
Chemical Properties
white crystalline powder
Uses
Glutarimide acts as an inhibitor of protein synthesis. Further, it is used as a reactant for thionations and biocatalytic asymmetric synthesis of sitagliptin production. It is also employed in the generation of beta-adrenoceptor ligands, enantioselective synthesis of securinega alkaloids and alfa-fluoro-alfa amino amides. In addition to this, it is used in intramolecular amidocyclopropanation reactions.
Preparation
To a flask containing 70 gm (0.53 mole) of glutaric acid is added 150 ml (2.2 mole) of 28% aqueous ammonia. The mixture is set for distillation and heated for 7 hr as the temperature of the mixture rises from 90° to 180°C. The temperature is held at 170-180°C for \\ hr or until the evolution of ammonia ceases. The reaction mixture solidifies on cooling and the product is recrystallized from acetone to afford 37.4 gm (63%), m.p. 145-146°C.
t may be advantageous to preform the ammonium salt of dicarboxylic acids prior to the application of enough heat to form the imide. The preparation of succinimide is a case in point.
Definition
ChEBI: A dicarboximide that is piperidine which is substituted by oxo groups at positions 2 and 6.
General Description
A glutarimide antibiotic, 9-methylstreptimidone, shows antiviral, antitumor and antifungal activities.
Purification Methods
Purify it by dissolving 75g in 200mL of H2O, boil for 30minutes with 2g of charcoal, filter, evaporate to dryness and recystallise the residue from 125mL of 95% EtOH to give 70g of white crystals, m 152-154o. It also crystallises from Me2CO (m 163-165o) or EtOH (m 153-154o). The N-bromo derivative (a brominating agent) crystallises from H2O with m 180-185o. [Paris et al. Org Synth Coll Vol IV 496 1963, Beilstein 21 H 382, 21 I 331, 21 II 307, 21 III/IV 4582.]
Glutarimide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9702 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Accela ChemBio Inc. | (+1)-858-699-3322 | info@accelachem.com | United States | 19965 | 58 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5909 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14336 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
View Lastest Price from Glutarimide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-10-16 | Glutarimide
1121-89-7
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | |
 |
2023-09-06 | Glutarimide
1121-89-7
|
US $0.00 / KG | 1KG | 99% | 500000kg | Hebei Guanlang Biotechnology Co., Ltd. | |
 |
2022-02-25 | Glutarimide
1121-89-7
|
US $8.99 / KG | 1KG | 99% | 100KG | Hong Kong Tiansheng New Material Trading Co., Ltd |
-
- Glutarimide
1121-89-7
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
-
- Glutarimide
1121-89-7
- US $0.00 / KG
- 99%
- Hebei Guanlang Biotechnology Co., Ltd.
-
- Glutarimide
1121-89-7
- US $8.99 / KG
- 99%
- Hong Kong Tiansheng New Material Trading Co., Ltd
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