Dinaphtho[2,3-b:2',3'-d]thiophene-5,7,12,13-tetrone
![Dinaphtho[2,3-b:2',3'-d]thiophene-5,7,12,13-tetrone Structure](CAS/20200611/GIF/22200-69-7.gif)
- CAS No.
- 22200-69-7
- Chemical Name:
- Dinaphtho[2,3-b:2',3'-d]thiophene-5,7,12,13-tetrone
- Synonyms
- Seriniquinone;Dinaphtho[2,3-b:2',3'-d]thiophene-5,7,12,13-tetrone
- CBNumber:
- CB22387534
- Molecular Formula:
- C20H8O4S
- Molecular Weight:
- 344.34
- MDL Number:
- MOL File:
- 22200-69-7.mol
| Melting point | 288 °C |
|---|---|
| Boiling point | 612.3±54.0 °C(Predicted) |
| Density | 1.578±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to 15 mg/ml with warming) or in DMF (up to 15 mg/ml) |
| form | solid |
| color | Orange |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 3 months. |
Dinaphtho[2,3-b:2',3'-d]thiophene-5,7,12,13-tetrone Chemical Properties,Uses,Production
Description
Seriniquinone (22200-69-7) is a new natural product isolated from a marine bacterium of the genus Serinicoccus. Displays selective toxicity against a distinct set of cell lines (within the NCI 60 panel) predominantly melanoma. Upon cellular treatment, seriniquinone was found to localize in the endoplasmic reticulum. Within 3 hours cells underwent autophagy followed by death via a caspase-9 apoptotic pathway. The target of seriniquinone was identified as the small protein, dermcidin, as determined using an immunoaffinity approach.1
Uses
Seriniquinone is a marine natural product, that displays potent cytotoxicity and selectivity against melanoma cancer cells.
References
1) Trzoss?et al. (2014),?Seriniquinone, a selective anticancer agent, induces cell death by autophagocytosis, targeting the cancer-protective protein dermcidin; Proc. Natl. Acad. Sci. USA,?111?14687
Dinaphtho[2,3-b:2',3'-d]thiophene-5,7,12,13-tetrone Preparation Products And Raw materials
Raw materials
Preparation Products
Dinaphtho[2,3-b:2',3'-d]thiophene-5,7,12,13-tetrone Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Zhengzhou Alpha Chemical Co. LTD | 0371-0371-53732842 13383863444 | 3002612166@qq.com | China | 10033 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 58 |
| Zhengzhou Alpha Chemical Co. LTD | 58 |