Ethyl bromodifluoroacetate
- CAS No.
- 667-27-6
- Chemical Name:
- Ethyl bromodifluoroacetate
- Synonyms
- 2-broMo-2,2-difluoroacetate;EBDA;2-Bromo-2,2-difluoroacetic acid ethyl ester;EBFA;bromodifL;Ethyl bromodifluoroa;Ethylbromdifluoracetat;Twoethyl broMidefluoride;ETHYL BROMODIFLUOROACETATE;difluorobromo ethyl acetate
- CBNumber:
- CB2238865
- Molecular Formula:
- C4H5BrF2O2
- Molecular Weight:
- 202.98
- MDL Number:
- MFCD00042069
- MOL File:
- 667-27-6.mol
- MSDS File:
- SDS
| Boiling point | 112 °C/700 mmHg (lit.) |
|---|---|
| Density | 1.583 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | 70 °F |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Soluble in most organic solvents. |
| form | Liquid |
| Specific Gravity | 1.583 |
| color | Clear colorless to slightly yellow |
| BRN | 1906095 |
| InChI | InChI=1S/C4H5BrF2O2/c1-2-9-3(8)4(5,6)7/h2H2,1H3 |
| InChIKey | IRSJDVYTJUCXRV-UHFFFAOYSA-N |
| SMILES | C(OCC)(=O)C(Br)(F)F |
| CAS DataBase Reference | 667-27-6(CAS DataBase Reference) |
| FDA UNII | 2QFZ6JJ5YH |
| NIST Chemistry Reference | Ethyl bromodifluoroacetate(667-27-6) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H314 | |||||||||
| Precautionary statements | P210-P233-P240-P280-P303+P361+P353-P305+P351+P338 | |||||||||
| Hazard Codes | C,F,Xi | |||||||||
| Risk Statements | 10-34-36 | |||||||||
| Safety Statements | 26-36/37/39-45-16-27 | |||||||||
| RIDADR | UN 2924 3/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant/Flammable | |||||||||
| TSCA | No | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29159000 | |||||||||
| NFPA 704 |
|
Ethyl bromodifluoroacetate price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 295795 | Ethyl bromodifluoroacetate 98% | 667-27-6 | 5g | $72.2 | 2024-03-01 | Buy |
| TCI Chemical | B1463 | Ethyl Bromodifluoroacetate >98.0%(GC) | 667-27-6 | 5g | $20 | 2024-03-01 | Buy |
| TCI Chemical | B1463 | Ethyl Bromodifluoroacetate >98.0%(GC) | 667-27-6 | 25g | $53 | 2024-03-01 | Buy |
| Alfa Aesar | B20461 | Ethyl bromodifluoroacetate, 97% | 667-27-6 | 5g | $65.65 | 2024-03-01 | Buy |
| TCI Chemical | B1463 | Ethyl Bromodifluoroacetate >98.0%(GC) | 667-27-6 | 250g | $306 | 2024-03-01 | Buy |
Ethyl bromodifluoroacetate Chemical Properties,Uses,Production
Description
Ethyl bromodifluoroacetate, a clear to yellow liquid, is an ester of bromodifluoroacetic acid and ethyl alcohol. It is an ester that can be used to introduce the CF2 group when synthesizing chemical compounds. Ethyl bromdifluoroacetate is considered to be a good compound in the generation of compounds and for testing with other organic compounds like lactones, imines, and other amino acids.
Chemical Properties
clear colorless to slightly yellow liquid
Uses
Efficient difluoroalkylation of aryl boronic acids via palladium catalysis. Novel, moisture-stable bromodifluoromethylated phosphonate, ester, and amide. Efficient coupling with aryl boronic acids via Pd catalysis. A Cu-catalyzed regioselective bromodifluoroacetylation of alkenes, using ethyl bromodifluoroacetate (BrCF2CO2Et) as a difluoroacetylating reagent.
Uses
Ethyl bromodifluoroacetate is usually used in the preparation of substituted ethyl 2′-pyridyldifluoroacetates,4-alkoxymethyl- and 4-aryloxymethyl-3,3-difluoropiperidines,α,α-difluoro-β-lactams,mono- and difluoromethylated phenanthridine derivatives.
Uses
Ethyl bromodifluoroacetate, is used for the treatment of the Reformat sky reagent with aldehydes and ketones affords 2,2-difluoro-3-hydroxy esters. It is also used in the analysis of reagent purity through IR, NMR.
Preparation
Difluorobromoacetonitrile is taken as a raw material, and prepared through a one-pot method and subjected to alcoholysis and esterification in ethanol aqueous solution to obtain ethyl bromodifluoroacetate.Reaction equation is:
BrF2CCN→BrF2CCOOH→BrF2CCOOC2H5
Ethyl bromodifluoroacetate Preparation Products And Raw materials
Raw materials
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Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| shandong exelon biochem co.ld | +86-533-2119995 +8615053330977 | 451614802@QQ.com | China | 28 | 58 |
| Changzhou Zechong Biopharma Co., Ltd. | +undefined18621330623 | sales@zechongchem.com | China | 28 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15928 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1807 | 55 |
| China Synchem Technology Co.,Ltd. | +86-0552-4929304 +86-18055277008 | wangxuhui1985@126.com | China | 55 | 55 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +86-18949832763 | info@tnjchem.com | China | 2989 | 55 |
| Zjartschem | +86-571-8723 8903 jocelynpan@zjarts.com | jocelynpan@zjarts.com | CHINA | 993 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
View Lastest Price from Ethyl bromodifluoroacetate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-09-06 | Ethyl bromodifluoroacetate
667-27-6
|
US $0.00 / KG | 1KG | 99% | 500000kg | Hebei Guanlang Biotechnology Co., Ltd. | |
 |
2023-04-14 | Ethyl bromodifluoroacetate
667-27-6
|
US $10.00 / KG | 1KG | 99.% | 10 ton | Hebei Guanlang Biotechnology Co,.LTD | |
 |
2022-10-10 | Ethyl bromodifluoroacetate
667-27-6
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. |
-
- Ethyl bromodifluoroacetate
667-27-6
- US $0.00 / KG
- 99%
- Hebei Guanlang Biotechnology Co., Ltd.
-
- Ethyl bromodifluoroacetate
667-27-6
- US $10.00 / KG
- 99.%
- Hebei Guanlang Biotechnology Co,.LTD
-
- Ethyl bromodifluoroacetate
667-27-6
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.
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