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(-)-INDOLACTAM V

CAS No.
90365-57-4
Chemical Name:
(-)-INDOLACTAM V
Synonyms
(-)-Ilv;IndolactaM;Brn 4711877;()-Indolactam V;(-)-INDOLACTAM V;(-)-Indolactam V;(-)-Indolactam V ()Indolactam V,( ) Indolactam V;(2s-(2r*,5r*))-ethyl)-1-methyl-2-(1-methylethyl);3h-pyrrolo(4,3,2-gh)-1,4-benzodiazonin-3-one,1,2,4,5,6,8-hexahydro-5-(hydroxym
CBNumber:
CB2244996
Molecular Formula:
C17H23N3O2
Molecular Weight:
301.38
MDL Number:
MFCD00151197
MOL File:
90365-57-4.mol
Last updated:2023-06-30 15:45:59

(-)-INDOLACTAM V Properties

Boiling point 584.0±50.0 °C(Predicted)
Density 1.166±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility DMSO: >10mg/mL, clear
form white powder
pka 14.39±0.10(Predicted)
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
FDA UNII 8CIY9O1323

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313
WGK Germany  3
RTECS  UY8547000

(-)-INDOLACTAM V price More Price(20)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich I0661 (?)-Indolactam V ≥96% (HPLC) 90365-57-4 1mg $354 2024-03-01 Buy
Cayman Chemical 14647 (-)-Indolactam V ≥95% 90365-57-4 500μg $158 2024-03-01 Buy
Cayman Chemical 14647 (?)-Indolactam V ≥97% 90365-57-4 1mg $299 2024-03-01 Buy
Cayman Chemical 14647 (?)-Indolactam V ≥97% 90365-57-4 300μg $120 2021-12-16 Buy
TRC I577325 (-)-IndolactamV 90365-57-4 10mg $4195 2021-12-16 Buy
Product number Packaging Price Buy
I0661 1mg $354 Buy
14647 500μg $158 Buy
14647 1mg $299 Buy
14647 300μg $120 Buy
I577325 10mg $4195 Buy

(-)-INDOLACTAM V Chemical Properties,Uses,Production

Description

Indolactam V (-) (90365-57-4) is a PKC activator acting at the phorbol ester binding site.1,2?Directs differentiation of human and mouse ESCs to pancreatic cells.3?? May be used, along with other agents, to differentiate human iPS cells into glucose-responsive insulin-secreting progeny.4?Increases regulator of G protein signaling 2 (RGS2) protein levels, a protein that regulates GPCR signaling.5

Uses

(-)-Indolactam V is an indole alkaloid compound which activates protein kinase C (PKC). Weak tumor promoter. Also directs differentiation of human embryonic stem cells, potentially into pancreatic lineage allowing for an effective diabetes therapy.

Definition

ChEBI: (-)-indolactam V is a 9-membered ring that is a potent protein kinase C activator

Biological Activity

Protein kinase C activator. Exhibits tumor promoting activity. Directs differentiation of human embryonic stem cells (ESCs) into pancreatic progenitors.

Biochem/physiol Actions

(-)-Indolactam V is a PKC activator shown to effect differentiation in embryonic stem cells leading to development of pancreatic precursors. It is active in the mouse model.

storage

-20°C (desiccate)

References

1) Fujiki?et al.?(1984),?Structure-activity studies on synthetic analogues (indolactams) of the tumor promoter teleocidin; Gan., 75?866 2) Heikkila and Ackerman (1989),?(-)-Indolactam V activates protein kinase C and induces changes in muscarinic receptor functions in SH-SY5Y human neuroblastoma cells; Biochem. Biophys. Res. Commun,?162?1207 3) Chen?et al.?(2009),?A small molecule that directs differentiation of human ESCs into the pancreatic lineage; Nat. Chem. Biol.,?5?258 4) Thalava?et al. (2011),?Indolactam V/GLP-1-mediated differentiation of human iPS cells into glucose-responsive insulin-secretin progeny; Gene Ther.,?18?283 5) Raveh (2014),?Identification of protein kinase C activation as a novel mechanism for RGS2 protein upregulation through phenotypic screening of natural product extracts; Mol. Pharmacol.,?86?406

(-)-INDOLACTAM V Preparation Products And Raw materials

Raw materials

Preparation Products

(-)-INDOLACTAM V Suppliers

Global( 47)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc.
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Finetech Industry Limited
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Jilin Chinese Academy of Sciences-yanshen Technology
+undefined18143011203 info@chemextension.com China 42057 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15848 69
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7553 61
Sichuan Wei Keqi Biological Technology Co., Ltd. 028-81700200 18116577057 3003855609@qq.com China 7893 56
Finetech Industry Limited 027-87465837 19945049750 sales@finetechnology-ind.com China 9590 58
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9709 58
Musechem +1-800-259-7612 info@musechem.com United States 4662 60
(2s-(2r*,5r*))-ethyl)-1-methyl-2-(1-methylethyl) 3h-pyrrolo(4,3,2-gh)-1,4-benzodiazonin-3-one,1,2,4,5,6,8-hexahydro-5-(hydroxym (-)-INDOLACTAM V (2S,5S)-1,2,4,5,6,8-Hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-3H-pyrrolo[4,3,2-gh]-1,4-benzodiazonin-3-one (-)-Ilv 3H-Pyrrolo(4,3,2-gh)-1,4-benzodiazonin-3-one, 1,2,4,5,6,8-hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-, (2S-(2R*,5R*))- 3H-Pyrrolo(4,3,2-gh)-1,4-benzodiazonin-3-one, 1,2,4,5,6,8-hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-, (2S,5S)- Brn 4711877 IndolactaM (-)-Indolactam V  ()-Indolactam V (-)-Indolactam V ()Indolactam V,( ) Indolactam V (2S,5S)-5-(Hydroxymethyl)-2-isopropyl-1-methyl-4,5,6,8-tetrahydro-1H-[1,4]diazonino[7,6,5-cd]indol-3(2H)-one 90365-57-4