TYRPHOSTIN A9
- CAS No.
- 10537-47-0
- Chemical Name:
- TYRPHOSTIN A9
- Synonyms
- AG 17;CS-743;SF 6847;gcp5126;s-15126;RG 50872;ent27910;MALONABEN;MALONOBEN;Malonobene
- CBNumber:
- CB2245711
- Molecular Formula:
- C18H22N2O
- Molecular Weight:
- 282.38
- MDL Number:
- MFCD00209853
- MOL File:
- 10537-47-0.mol
| Melting point | 141-143℃ (ethanol ) |
|---|---|
| Boiling point | 424.99°C (rough estimate) |
| Density | 1.0741 (rough estimate) |
| refractive index | 1.5700 (estimate) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | ethanol: 20 mg/mL |
| form | solid |
| pka | 7.55±0.40(Predicted) |
| color | yellow |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| CAS DataBase Reference | 10537-47-0(CAS DataBase Reference) |
| FDA UNII | 87TE8MRS65 |
| EPA Substance Registry System | Malonoben (10537-47-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301+H311 | |||||||||
| Precautionary statements | P264-P270-P280-P301+P310-P302+P352+P312-P361+P364 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 23/24/25 | |||||||||
| Safety Statements | 36/37/39-45 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | OO3737000 | |||||||||
| HS Code | 2926.90.5050 | |||||||||
| HazardClass | 6.1 | |||||||||
| NFPA 704 |
|
TYRPHOSTIN A9 price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | T182 | Tyrphostin A9 solid | 10537-47-0 | 5mg | $117 | 2024-03-01 | Buy |
| Sigma-Aldrich | S481777 | 2-(3,5-DI-TERT-BUTYL-4-HYDROXY-BENZYLIDENE)-MALONONITRILE AldrichCPR | 10537-47-0 | 25MG | $179 | 2024-03-01 | Buy |
| Sigma-Aldrich | 658425 | AG 17 | 10537-47-0 | 5mg | $85.2 | 2024-03-01 | Buy |
| TCI Chemical | T3667 | Tyrphostin A9 >98.0%(GC) | 10537-47-0 | 25mg | $69 | 2024-03-01 | Buy |
| TCI Chemical | T3667 | Tyrphostin A9 >98.0%(GC) | 10537-47-0 | 100mg | $206 | 2024-03-01 | Buy |
TYRPHOSTIN A9 Chemical Properties,Uses,Production
Description
Tyrphostin 9 (10537-47-0) inhibits PDGF receptor tyrosine kinase (IC50?= 1.2 μM)1and is a potent (10 nM) inhibitor of oxidative phosphorylation2. Inhibits cell growth by disrupting mitochondria.3 Tyrphostin 9 perturbs the golgi complex and blocks proliferation of vascular smooth muscle cells.4
Uses
Selective inhibitor of PDGF receptor tyrosine kinase
Uses
SF 6847 is an inhibitor of EGFR with IC50 of 460 μM.
Uses
Tyrphostin A9 can be used for inhibiting tyrosine kinase functions in C2C12 cells. It has also been used to disrupt membrane potential in mammalian cells.
Definition
ChEBI: Malonoben is an alkylbenzene. It has a role as a geroprotector.
General Description
A selective, cell-permeable, reversible, and substrate competitive inhibitor of the platelet-derived growth factor receptor tyrosine kinase (IC50 = 500 nM). Anti-proliferative agent. Uncoupler of oxidative phosphorylation. Induces apoptosis in vitro and cell growth arrest in NHL cell lines.
Biological Activity
Potent uncoupler of oxidative phosphorylation.
Biochem/physiol Actions
Cell permeable: yes
References
1) Bilder?et al. (1991),?Tyrphostins inhibit PDGF-induced DNA synthesis and associated early events in smooth muscle cells; Am. J. Physiol.,?260?C721 2) Terada?et al. (1981),?The interaction of highly active uncouplers with mitochondria; Biochim. Biophys. Acta,?639?225 3) Burger?et al. (1995),?Tyrphostin AG17, [3,5-Ditert-butyl-4-hydroxybenzylidene)-malononitrile], inhibits cell growth by disrupting mitochondria; Cancer Res.,?55?2794 4) Thyberg?et al. (1998),?Tyrphostin A9 and wortmannin perturb the Golgi complex and block proliferation of vascular smooth muscle cells; Eur. J. Cell Biol.,?76?33
TYRPHOSTIN A9 Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21149 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29321 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
View Lastest Price from TYRPHOSTIN A9 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-09-06 | TYRPHOSTIN A9OLECARBOXYLATE
10537-47-0
|
US $1.00 / KG | 1KG | 95%~99% | per week 100kg | Career Henan Chemical Co |
-
- TYRPHOSTIN A9OLECARBOXYLATE
10537-47-0
- US $1.00 / KG
- 95%~99%
- Career Henan Chemical Co