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Ampicillin

Ampicillin
Ampicillin
CAS No.
69-53-4
Chemical Name:
Ampicillin
Synonyms
p-50;ab-pc;Wymox;qidamp;Unasyn;amfipen;ampicin;ampimed;ay-6108;binotal
CBNumber:
CB2247346
Molecular Formula:
C16H19N3O4S
Formula Weight:
349.41
MOL File:
69-53-4.mol

Ampicillin Properties

Melting point:
198-200 °C (dec.)(lit.)
alpha 
D23 +287.9° (c = 1 in water)
storage temp. 
2-8°C
solubility 
NH4OH 1 M: 50 mg/mL, clear, colorless
pka
2.5 (COOH)(at 25℃)
Merck 
13,591
Stability:
Stable, but may be moisture sensitive. Incopmpatible with strong oxidizing agents.
CAS DataBase Reference
69-53-4(CAS DataBase Reference)
EPA Substance Registry System
4-Thia-1-azabicyclo[ 3.2.0]heptane-2-carboxylic acid, 6-[[(2R)-aminophenylacetyl] amino]-3,3-dimethyl-7-oxo-, (2S,5R,6R)-(69-53-4)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn,T
Risk Statements  36/37/38-42/43-61
Safety Statements  22-26-36/37-45-53
WGK Germany  2
RTECS  XH8425000
10-23
HS Code  29212900
Hazardous Substances Data 69-53-4(Hazardous Substances Data)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled Sensitisation, respiratory Category 1 Danger P261, P285, P304+P341, P342+P311,P501
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P284 Wear respiratory protection.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P333+P313 IF SKIN irritation or rash occurs: Get medical advice/attention.
P342+P311 IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P405 Store locked up.

Ampicillin price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 59349 Ampicillin analytical standard 69-53-4 100mg $37.5 2017-11-08 Buy
Sigma-Aldrich 1033000 Ampicillin United States Pharmacopeia (USP) Reference Standard 69-53-4 200mg $348.4 2017-11-08 Buy
Alfa Aesar J60977 Ampicillin 69-53-4 25g $196 2017-11-08 Buy
Alfa Aesar J60977 Ampicillin 69-53-4 5g $41.8 2017-11-08 Buy
Sigma-Aldrich A9393 Ampicillin anhydrous, 96.0-100.5% (anhydrous basis) 69-53-4 5g $63.8 2017-11-08 Buy

Ampicillin Chemical Properties,Uses,Production

Description

Ampicillin is an antibacterial antibiotic from the α-aminobenzyl penicillin group, which differs from penicillin by the presence of an amino group that facilitates penetration through the outer membrane of some gram-negative bacteria.
Ampicillin is Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic. Ampicillin acts by interfering directly with the biosynthesis of peptidoglycan, which constitutes the major component of the bacterial cell wall, leading to structural instability and death of bacteria.
Ampicillin is a β-lactam antibiotic within the penicillin family. As a member of this family, Ampicillin is susceptible to β-lactamase, which hydrolyzes the β-lactam ring. This broad spectrum antibiotic is effective against gram-positive, gram-negative bacteria and anaerobic bacteria. Ampicillin is widely used in cell culture as a selective agent. As an antibiotic, Ampicillin binds to penicillin binding proteins (PBPs) on a susceptible organism and Inhibits bacterial cell-wall synthesis by inactivating transpeptidases on the inner surface of the bacterial cell membrane. After binding to the PBPs, Ampicilin acts as a structural analogue of acyl-D-alanyl-D-alanine, acylates the transpeptidase enzyme and thereby prevents the cross-linking of the peptidoglycan of the cell wall necessary for the growth of the bacterium.
Ampicillin sodium can be used as a selective agent in several types of isolation media. Ampicillin sodium is routinely used to select for cells containing the pcDNA3.1 and pEAK10 resistance plasmids in cell line A904L at an effective concentration of 50 μg/ml.

Chemical Properties

Crystalline Solid

Uses

β-lactam antibiotics

Uses

Labelled Ampicillin. Orally active, semi-synthetic antibiotic; structurally related to penicillin. Antibacterial.

Definition

ChEBI: A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-phenylacetamido group.

Ampicillin Preparation Products And Raw materials

Raw materials

Preparation Products


Ampicillin Suppliers

Global( 184)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3229 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20809 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32766 55
PI & PI BIOTECH INC.
020-81716320
020-81716319 Sales@pipitech.com CHINA 2155 55
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96817 76
3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:18930552037
86-21-50328109 3bsc@sina.com China 15940 69
Chemfun Medical Technology(Shanghai) Co., Ltd. 021-67220633 & 021-37212706
+86-21-67220638 chemfun@chemfun.net China 21899 59
LGM Pharma 1-(800)-881-8210
615-250-9817 inquiries@lgmpharma.com United States 1960 70
Nanjing Chemlin Chemical Co., Ltd 025-83697070
+86-25-83453306 sales@chemlin.com.cn China 19982 64
Chemsky(shanghai)International Co.,Ltd. 021-50135380
shchemsky@sina.com China 32525 50

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